Impaired Angiogenesis and Th1/Th17 Polarization: A Possible Explanation for the Decreased Incidence of Rosacea in the Aged DOI Creative Commons
Juan Long, Zhili Deng, Mengting Chen

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

ABSTRACT Background Rosacea is a common inflammatory skin disorder characterized by frequent facial flushing, erythema, telangiectasia, and papules, with higher incidence observed in individuals aged 30−50 years tendency to decrease the elderly. This age‐related decline drew our attention further explore relationship between rosacea pathogenesis aging. Methods We analyzed of across 8340 without systemic diseases. The effects LL37‐induced rosacea‐like erythema inflammation were evaluated both young mice. Immunofluorescence analysis was performed assess microvessel density, whereas expression levels angiogenesis‐related factors, including matrix metalloproteinases (MMPs) vascular endothelial growth factor α (VEGFα), quantified. Additionally, immune responses assessed at cellular levels. Results Aged mice displayed milder compared their counterparts. revealed density models group. MMPs VEGFα, decreased mice, indicating reduced responsiveness LL37 stimulation. Furthermore, we found that suppressed Th1‐ Th17‐polarized responses, one major pathogenic mechanisms rosacea, response stimulation Conclusion findings suggest impaired angiogenesis attenuated Th1/Th17 underlie incidence.

Language: Английский

Fungi, immunosenescence and cancer DOI Creative Commons
Bin Xu,

Zan Luo,

Xing Niu

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 109, P. 67 - 82

Published: Jan. 7, 2025

Language: Английский

Citations

4
Benefit delayed immunosenescence by regulating CD4+T cells: A promising therapeutic target for aging‐related diseases DOI Creative Commons
Tingting Xia, Ying Zhou, J.Y. An

et al.

Aging Cell, Journal Year: 2024, Volume and Issue: 23(10)

Published: Aug. 18, 2024

CD4

Language: Английский

Citations

5
Patient-Centric Approach for the Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease in Older People DOI

Kevin T Mueller,

Alene A Saavedra,

Lauren A. O’Keeffe

et al.

Drugs & Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

Citations

0
Reshaping the immune microenvironment and reversing immunosenescence by natural products: prospects for immunotherapy in gastric cancer DOI
Zhipeng Cao, Zhilin Wang, Yang Li

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: 110, P. 1 - 16

Published: Feb. 8, 2025

Language: Английский

Citations

0
Impaired Angiogenesis and Th1/Th17 Polarization: A Possible Explanation for the Decreased Incidence of Rosacea in the Aged DOI Creative Commons
Juan Long, Zhili Deng, Mengting Chen

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(12)

Published: Dec. 1, 2024

ABSTRACT Background Rosacea is a common inflammatory skin disorder characterized by frequent facial flushing, erythema, telangiectasia, and papules, with higher incidence observed in individuals aged 30−50 years tendency to decrease the elderly. This age‐related decline drew our attention further explore relationship between rosacea pathogenesis aging. Methods We analyzed of across 8340 without systemic diseases. The effects LL37‐induced rosacea‐like erythema inflammation were evaluated both young mice. Immunofluorescence analysis was performed assess microvessel density, whereas expression levels angiogenesis‐related factors, including matrix metalloproteinases (MMPs) vascular endothelial growth factor α (VEGFα), quantified. Additionally, immune responses assessed at cellular levels. Results Aged mice displayed milder compared their counterparts. revealed density models group. MMPs VEGFα, decreased mice, indicating reduced responsiveness LL37 stimulation. Furthermore, we found that suppressed Th1‐ Th17‐polarized responses, one major pathogenic mechanisms rosacea, response stimulation Conclusion findings suggest impaired angiogenesis attenuated Th1/Th17 underlie incidence.

Language: Английский

Citations

0