Intermittent theta burst to the left dorsolateral prefrontal cortex promoted decreased alcohol consumption and improved outcomes in those with alcohol use disorder: a randomized, double-blind, placebo-controlled clinical trial
Drug and Alcohol Dependence,
Год журнала:
2025,
Номер
270, С. 112641 - 112641
Опубликована: Март 1, 2025
Язык: Английский
Developing a reverse translational model of low-intensity rTMS in Alcohol Use Disorder: the influence of theta burst stimulation protocols on binge alcohol drinking in mice
Transcranial magnetic stimulation .,
Год журнала:
2025,
Номер
unknown, С. 100098 - 100098
Опубликована: Апрель 1, 2025
Язык: Английский
Accelerated Deep TMS in Alcohol Use Disorder: A Preliminary Pilot Trial Targeting the Dorsal Anterior Cingulate Cortex Increases Neural Target Engagement and Abstinence
Brain stimulation,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
The Future of Alcohol Use Disorder Treatment and Research
Psychiatry update,
Год журнала:
2024,
Номер
unknown, С. 189 - 203
Опубликована: Янв. 1, 2024
Язык: Английский
Neural TMS target identification and randomized controlled trial for functional disability with alcohol related characteristics among Veterans with co-occurring alcohol use disorder and mild traumatic brain injury: Protocol for TMS TARGET for AUD+mTBI (Preprint)
Опубликована: Дек. 20, 2024
BACKGROUND
Alcohol
use
disorder
and
mild
traumatic
brain
injury
(AUD+mTBI)
commonly
co-occur
resulting
in
exacerbation
of
symptoms,
negatively
impacting
function.
The
co-occurrence
AUD+mTBI
theoretically
represents
a
unique
heterogenous
state
that
impacts
symptoms
Repetitive
transcranial
magnetic
stimulation
(rTMS)
is
non-invasive
neuromodulatory
treatment
with
burgeoning
evidence
for
improving
function
AUD
mTBI
each
alone.
However,
there
no
consensus
on
optimal
neural
target
or
site
either
these
conditions
alone,
when
they
co-occur.
OBJECTIVE
1)
Test
preliminary
efficacy
high-frequency
rTMS
provided
to
customized
treat
functional
disability
among
Veterans
AUD+mTBI.
2)
Assess
sustainability
effects
METHODS
This
single-blind,
RCT
including
will
be
randomized
one
2
groups:
(1)
novel
TMS
using
neuronavigation
(2)
standard
clinical
left
DLPFC
the
Beam
F3
method.
All
participants
first
receive
10
sessions
(1
session/day)
sham
followed
by
active
(10Hz).
complete
study
outcomes
pre-
post-
session
blocks
as
well
at
2-week,
1-month,
3-month
6-month
post-treatment
follow-up
timepoints.
primary
outcome
World
Health
Organization
Disability
Assessment
Schedule
2.0
(WHODAS
2.0).
Secondary
include
following:
alcohol
Timeline
Followback
(TLFB)
Calendar,
Penn
Craving
Scale
(PACS),
Obsessive
Compulsive
Drinking
(OCDS),
Questionnaire
(ACQ-NOW),
Neurobehavioral
Symptom
Inventory
(NSI),
PTSD
Checklist
DSM-5
(PCL-5),
Beck
Depression
Inventory-II
(BDI-II),
Anxiety
(BAI),
Mood
(MASQ).
RESULTS
protocol
was
approved
Edward
Hines
Jr.
Administration
Hospital
Institutional
Review
Board
(Hines
IRB
19-021).
prospectively
registered
ClinicalTrials.gov
(NCT04043442).
includes
Food
Drug
Investigational
Device
Exemption
(IDE:
G180292).
A
6-year
research
plan
timeline
developed
cost/no-cost
extensions
due
COVID-19
pandemic.
As
August
2024,
total
27
are
enrolled
completed
identification
phase
awaiting
enrollment
phase.
Data
collection
ongoing
May
2026.
We
expect
results
this
available
2027.
CONCLUSIONS
able
provide
safety
feasibility,
co-occurring
CLINICALTRIAL
NCT04043442
https://clinicaltrials.gov/study/NCT04043442?tab=results
Язык: Английский
Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis
Journal of Addiction Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
We
aimed
to
evaluate
the
immediate
and
up
3
months'
effect
of
multiple-session
repetitive
transcranial
magnetic
stimulation
(rTMS)
on
alcohol
craving
in
AUD.
Язык: Английский
Customized neural TMS target for functional disability among Veterans with co-occurring alcohol use disorder and mild traumatic brain injury: Protocol for TMS TARGET for AUD+mTBI Pilot Randomized Controlled Trial (Preprint)
JMIR Research Protocols,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Язык: Английский