Intermittent theta burst to the left dorsolateral prefrontal cortex promoted decreased alcohol consumption and improved outcomes in those with alcohol use disorder: a randomized, double-blind, placebo-controlled clinical trial
Drug and Alcohol Dependence,
Journal Year:
2025,
Volume and Issue:
270, P. 112641 - 112641
Published: March 1, 2025
Language: Английский
Developing a reverse translational model of low-intensity rTMS in Alcohol Use Disorder: the influence of theta burst stimulation protocols on binge alcohol drinking in mice
Akriti Dhungana,
No information about this author
Daniel M. McCalley,
No information about this author
Alesha Heath
No information about this author
et al.
Transcranial magnetic stimulation .,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100098 - 100098
Published: April 1, 2025
Language: Английский
Accelerated Deep TMS in Alcohol Use Disorder: A Preliminary Pilot Trial Targeting the Dorsal Anterior Cingulate Cortex Increases Neural Target Engagement and Abstinence
C L A U D I A B Padula,
No information about this author
Lea‐Tereza Tenekedjieva,
No information about this author
D A N I E L M McCalley
No information about this author
et al.
Brain stimulation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 1, 2024
Language: Английский
The Future of Alcohol Use Disorder Treatment and Research
Anuranjan Srivastava,
No information about this author
Jonathan Wai
No information about this author
Psychiatry update,
Journal Year:
2024,
Volume and Issue:
unknown, P. 189 - 203
Published: Jan. 1, 2024
Language: Английский
Neural TMS target identification and randomized controlled trial for functional disability with alcohol related characteristics among Veterans with co-occurring alcohol use disorder and mild traumatic brain injury: Protocol for TMS TARGET for AUD+mTBI (Preprint)
Published: Dec. 20, 2024
BACKGROUND
Alcohol
use
disorder
and
mild
traumatic
brain
injury
(AUD+mTBI)
commonly
co-occur
resulting
in
exacerbation
of
symptoms,
negatively
impacting
function.
The
co-occurrence
AUD+mTBI
theoretically
represents
a
unique
heterogenous
state
that
impacts
symptoms
Repetitive
transcranial
magnetic
stimulation
(rTMS)
is
non-invasive
neuromodulatory
treatment
with
burgeoning
evidence
for
improving
function
AUD
mTBI
each
alone.
However,
there
no
consensus
on
optimal
neural
target
or
site
either
these
conditions
alone,
when
they
co-occur.
OBJECTIVE
1)
Test
preliminary
efficacy
high-frequency
rTMS
provided
to
customized
treat
functional
disability
among
Veterans
AUD+mTBI.
2)
Assess
sustainability
effects
METHODS
This
single-blind,
RCT
including
will
be
randomized
one
2
groups:
(1)
novel
TMS
using
neuronavigation
(2)
standard
clinical
left
DLPFC
the
Beam
F3
method.
All
participants
first
receive
10
sessions
(1
session/day)
sham
followed
by
active
(10Hz).
complete
study
outcomes
pre-
post-
session
blocks
as
well
at
2-week,
1-month,
3-month
6-month
post-treatment
follow-up
timepoints.
primary
outcome
World
Health
Organization
Disability
Assessment
Schedule
2.0
(WHODAS
2.0).
Secondary
include
following:
alcohol
Timeline
Followback
(TLFB)
Calendar,
Penn
Craving
Scale
(PACS),
Obsessive
Compulsive
Drinking
(OCDS),
Questionnaire
(ACQ-NOW),
Neurobehavioral
Symptom
Inventory
(NSI),
PTSD
Checklist
DSM-5
(PCL-5),
Beck
Depression
Inventory-II
(BDI-II),
Anxiety
(BAI),
Mood
(MASQ).
RESULTS
protocol
was
approved
Edward
Hines
Jr.
Administration
Hospital
Institutional
Review
Board
(Hines
IRB
19-021).
prospectively
registered
ClinicalTrials.gov
(NCT04043442).
includes
Food
Drug
Investigational
Device
Exemption
(IDE:
G180292).
A
6-year
research
plan
timeline
developed
cost/no-cost
extensions
due
COVID-19
pandemic.
As
August
2024,
total
27
are
enrolled
completed
identification
phase
awaiting
enrollment
phase.
Data
collection
ongoing
May
2026.
We
expect
results
this
available
2027.
CONCLUSIONS
able
provide
safety
feasibility,
co-occurring
CLINICALTRIAL
NCT04043442
https://clinicaltrials.gov/study/NCT04043442?tab=results
Language: Английский
Repetitive Transcranial Magnetic Stimulation for Alcohol Craving in Alcohol Use Disorders: A Meta-analysis
Journal of Addiction Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
We
aimed
to
evaluate
the
immediate
and
up
3
months'
effect
of
multiple-session
repetitive
transcranial
magnetic
stimulation
(rTMS)
on
alcohol
craving
in
AUD.
Language: Английский
Customized neural TMS target for functional disability among Veterans with co-occurring alcohol use disorder and mild traumatic brain injury: Protocol for TMS TARGET for AUD+mTBI Pilot Randomized Controlled Trial (Preprint)
JMIR Research Protocols,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 20, 2024
Language: Английский