
Epigenomics, Год журнала: 2023, Номер 15(1), С. 5 - 10
Опубликована: Янв. 1, 2023
Язык: Английский
Epigenomics, Год журнала: 2023, Номер 15(1), С. 5 - 10
Опубликована: Янв. 1, 2023
Язык: Английский
Science Technology & Human Values, Год журнала: 2024, Номер unknown
Опубликована: Авг. 2, 2024
New and emerging forensic genetics technologies offer significant insight into personal information, changing the way that policing criminal justice uses of such are being considered legitimized. In this article, based on data from Central Western European countries United States America, we analyze how compounding, interdependent effects four technologies—massive parallel sequencing, epigenetics, DNA phenotyping, genetic genealogy—facilitate dissolving boundaries between medical, as well commercial non-commercial domains. Mobilizing social epistemology epistemic culture dual analytical lens, argue can witness emergence an increasingly complex assemblage, fostering dependencies agencies, research scientists, companies. At heart assemblage lies transformation central knowledge claims distinct roles responsibilities defining legitimate application information in contexts. The deepening co-dependencies within encourage increased self-governance key stakeholders, to detriment field's societal accountability legitimacy. discussion article provides a necessary starting point for reframing genetics’ governance.
Язык: Английский
Процитировано
1Alcohol Clinical and Experimental Research, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 12, 2024
This critical review summarizes the current state of omics-based biomarkers in alcohol research field. We first provide definitions and background information on use disorder (AUD), biomarkers, "omic" technologies. next summarize using (1) genetic as risk/prognostic for onset alcohol-related problems progression from regular drinking to problematic (including AUD), (2) epigenetic diagnostic AUD risk consumption, (3) transcriptomic AUD, (4) metabolomic predictive response acamprosate subjects with AUD. In final section, clinical implications findings are discussed, recommendations made future research.
Язык: Английский
Процитировано
1Epigenomes, Год журнала: 2024, Номер 9(1), С. 1 - 1
Опубликована: Дек. 24, 2024
Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is relative lack of tools that are easily implementable in clinical settings and can be used to supplement self-reporting the diagnosis management HAC. In part, this paucity due limitations currently available biological measures mismatch between needs clinicians managing We first review pros cons existing measures. Next, we underlying theory performance characteristics two recently developed methylation-sensitive digital PCR (MSdPCR) assays, referred as Alcohol T Score (ATS) ZSCAN25, for assessment chronic recent HAC, respectively. Finally, outline paradigm improving use disorders by utilizing these new markers consumption. conclude further studies understand test each epigenetic larger, diverse populations order.
Язык: Английский
Процитировано
1Elsevier eBooks, Год журнала: 2022, Номер unknown, С. 747 - 767
Опубликована: Янв. 1, 2022
Язык: Английский
Процитировано
6Epigenomics, Год журнала: 2023, Номер 15(1), С. 5 - 10
Опубликована: Янв. 1, 2023
Язык: Английский
Процитировано
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