Dissolving Boundaries, Fostering Dependencies. the new Forensic Genetics Assemblage

Science Technology & Human Values, Год журнала: 2024, Номер unknown

Опубликована: Авг. 2, 2024

New and emerging forensic genetics technologies offer significant insight into personal information, changing the way that policing criminal justice uses of such are being considered legitimized. In this article, based on data from Central Western European countries United States America, we analyze how compounding, interdependent effects four technologies—massive parallel sequencing, epigenetics, DNA phenotyping, genetic genealogy—facilitate dissolving boundaries between medical, as well commercial non-commercial domains. Mobilizing social epistemology epistemic culture dual analytical lens, argue can witness emergence an increasingly complex assemblage, fostering dependencies agencies, research scientists, companies. At heart assemblage lies transformation central knowledge claims distinct roles responsibilities defining legitimate application information in contexts. The deepening co-dependencies within encourage increased self-governance key stakeholders, to detriment field's societal accountability legitimacy. discussion article provides a necessary starting point for reframing genetics’ governance.

Язык: Английский

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Next‐generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review

Alcohol Clinical and Experimental Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 12, 2024

This critical review summarizes the current state of omics-based biomarkers in alcohol research field. We first provide definitions and background information on use disorder (AUD), biomarkers, "omic" technologies. next summarize using (1) genetic as risk/prognostic for onset alcohol-related problems progression from regular drinking to problematic (including AUD), (2) epigenetic diagnostic AUD risk consumption, (3) transcriptomic AUD, (4) metabolomic predictive response acamprosate subjects with AUD. In final section, clinical implications findings are discussed, recommendations made future research.

Язык: Английский

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Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption

Epigenomes, Год журнала: 2024, Номер 9(1), С. 1 - 1

Опубликована: Дек. 24, 2024

Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is relative lack of tools that are easily implementable in clinical settings and can be used to supplement self-reporting the diagnosis management HAC. In part, this paucity due limitations currently available biological measures mismatch between needs clinicians managing We first review pros cons existing measures. Next, we underlying theory performance characteristics two recently developed methylation-sensitive digital PCR (MSdPCR) assays, referred as Alcohol T Score (ATS) ZSCAN25, for assessment chronic recent HAC, respectively. Finally, outline paradigm improving use disorders by utilizing these new markers consumption. conclude further studies understand test each epigenetic larger, diverse populations order.

Язык: Английский

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Cholesterol and alcohol

Elsevier eBooks, Год журнала: 2022, Номер unknown, С. 747 - 767

Опубликована: Янв. 1, 2022

Язык: Английский

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The Epigenome as a Biological Candidate to Incorporate the Social Environment Over the Life Course and Generations

Epigenomics, Год журнала: 2023, Номер 15(1), С. 5 - 10

Опубликована: Янв. 1, 2023

Язык: Английский

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