The role of alcohol intake in the pharmacogenetics of treatment with clozapine DOI
Nancy Monroy‐Jaramillo, José Jaime Martínez‐Magaña, Blanca Estela Pérez-Aldana

et al.

Pharmacogenomics, Journal Year: 2022, Volume and Issue: 23(6), P. 371 - 392

Published: March 21, 2022

Clozapine (CLZ) is an atypical antipsychotic reserved for patients with refractory psychosis, but it associated a significant risk of severe adverse reactions (ADRs) that are potentiated the concomitant use alcohol. Additionally, pharmacogenetic studies have explored influence several genetic variants in CYP450, receptors and transporters involved interindividual response to CLZ. Herein, we systematically review current multiomics knowledge behind interaction between CLZ alcohol intake, how its might modulate pharmacogenetics. CYP1A2*1F, *1C other alleles not yet discovered could support precision medicine approach better therapeutic effects fewer ADRs. monitoring systems should be amended include intake protect from

Language: Английский

Cholesterol and alcohol DOI
Andrew S. Bell, Emma M. O’Connell, Falk W. Lohoff

et al.

Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 747 - 767

Published: Jan. 1, 2022

Language: Английский

Citations

6
The Epigenome as a Biological Candidate to Incorporate the Social Environment Over the Life Course and Generations DOI Creative Commons
Raphaële Castagné, Sandrine Ménard, Cyrille Delpierre

et al.

Epigenomics, Journal Year: 2023, Volume and Issue: 15(1), P. 5 - 10

Published: Jan. 1, 2023

Language: Английский

Citations

3
The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders DOI
Francesca Fanfarillo, Giampiero Ferraguti, Marco Lucarelli

et al.

Current Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 31(36), P. 5837 - 5855

Published: Oct. 13, 2023

Alcohol use disorders are responsible for 5.9% of all death annually and 5.1% the global disease burden. It has been suggested that alcohol abuse can modify gene expression through epigenetic processes, namely DNA histone methylation, acetylation, microRNA expression. The influence on mechanisms leads to molecular adaptation a wide number brain circuits, including hypothalamus-hypophysis-adrenal axis, prefrontal cortex, mesolimbic-dopamine pathways endogenous opioid pathways. Epigenetic regulation represents an important level alcohol-induced in brain. demonstrated acute chronic exposure induce opposite modifications mechanisms: increases decreases methylation inhibits methyltransferase activity, while induces hypermethylation DNA. Some studies investigated chromatin status during withdrawal period craving showed was associated with low status, elevated activity deacetylase decreased acetylation. Given effects exerted by ethanol consumption mechanisms, structure modifiers, such as inhibitors inhibitors, might represent new potential strategy treat disorder. Further investigations induced be helpful develop therapies alcoholism drug addiction targeting processes.

Language: Английский

Citations

3
Multi‐omics analysis of alcohol effects on the liver in young and aged mice DOI Creative Commons
Lea Zillich, Josephin Wagner, Rachel H. McMahan

et al.

Addiction Biology, Journal Year: 2023, Volume and Issue: 28(12)

Published: Nov. 14, 2023

Abstract Excessive alcohol consumption has detrimental effects on the entire organism, especially liver. The toxicity is partly dependent age, as older individuals metabolize more slowly leading to increased cellular injury. This study aimed investigate of moderate binge drinking liver young and aged mice in a genome‐wide multi‐omics approach. We determined DNA methylation (DNAm) using Illumina MouseMethylation array gene expression by RNA sequencing 18 female Balb/c 2 × design. animals underwent three cycles (ethanol vs. vehicle) tissue was harvested at 4 or 19 months age. tested differential (DE) DNAm associated with ethanol intake linear models separately mice, performed enrichment analyses for pathways GWAS signatures problematic use, analysed overlap expression. observed DE substantial genes such Bhlhe40 , Klf10 Frmd8 . were enriched biological processes related metabolism, inflammation, fibrosis, use. identified overlapping from expression, example, St6galnac4 mice. offers converging evidence novel age‐related targets model highlighting dysregulations fibrosis. Future studies are needed confirm these results elucidate underlying mechanisms.

Language: Английский

Citations

3
The role of alcohol intake in the pharmacogenetics of treatment with clozapine DOI
Nancy Monroy‐Jaramillo, José Jaime Martínez‐Magaña, Blanca Estela Pérez-Aldana

et al.

Pharmacogenomics, Journal Year: 2022, Volume and Issue: 23(6), P. 371 - 392

Published: March 21, 2022

Clozapine (CLZ) is an atypical antipsychotic reserved for patients with refractory psychosis, but it associated a significant risk of severe adverse reactions (ADRs) that are potentiated the concomitant use alcohol. Additionally, pharmacogenetic studies have explored influence several genetic variants in CYP450, receptors and transporters involved interindividual response to CLZ. Herein, we systematically review current multiomics knowledge behind interaction between CLZ alcohol intake, how its might modulate pharmacogenetics. CYP1A2*1F, *1C other alleles not yet discovered could support precision medicine approach better therapeutic effects fewer ADRs. monitoring systems should be amended include intake protect from

Language: Английский

Citations

4