The burden of co-occurring alcohol use disorder and PTSD in U.S. Military veterans: Comorbidities, functioning, and suicidality.

Psychology of Addictive Behaviors, Год журнала: 2018, Номер 32(2), С. 224 - 229

Опубликована: Март 1, 2018

Alcohol use disorder (AUD) and posttraumatic stress (PTSD) are among the most prevalent disorders in U.S. military veterans often co-occur. To date, studies have focused on treatment-seeking samples, although many with AUD/PTSD do not seek treatment. We evaluated prevalence of psychiatric comorbidities, functioning, quality life a nationally representative sample (using data from National Health Resilience Veterans Study) AUD alone, PTSD comorbid to understand incremental burden having both relative either one. Among those probable AUD, 20.3% met criteria for PTSD. those, PTSD, 16.8% AUD. Compared only, were more likely screen positive major depression (36.8% vs. 2.3%), generalized anxiety (43.5% 2.9%), suicidal ideation (39.1% 7.0%); attempted suicide (46.0% 4.1%); be receiving mental health treatment (44.8% 7.5%). They also scored lower cognitive (d = 0.50), 0.51) physical 0.21) (Cohen d 0.46). than three times as only their lifetimes (odds ratio 3.1, 95% confidence interval 1.8-5.3; 46.0% 22.8%); they did differ other measures. Results underscore co-occurring veterans, importance engaging these (PsycINFO Database Record

Язык: Английский

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Influence of comorbid alcohol use disorders on the clinical patterns of major depressive disorder: A general population-based study

Drug and Alcohol Dependence, Год журнала: 2018, Номер 187, С. 40 - 47

Опубликована: Март 23, 2018

Язык: Английский

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Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence

JAMA Psychiatry, Год журнала: 2017, Номер 74(11), С. 1153 - 1153

Опубликована: Авг. 16, 2017

Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, they frequently comorbid. Common genetic factors that influence the co-occurrence of MDD AD have been sought in family, twin, adoption studies, results to date promising but inconclusive.

Язык: Английский

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Posttraumatic Stress Disorder and Alcohol Use Disorder: A Critical Review of Pharmacologic Treatments

Alcoholism Clinical and Experimental Research, Год журнала: 2017, Номер 41(2), С. 226 - 237

Опубликована: Янв. 19, 2017

Treatment of alcohol use disorder ( AUD ) is complicated by the presence psychiatric comorbidity including posttraumatic stress PTSD ). This a critical review literature to date on pharmacotherapy treatments and . A systematic search using PubMed MESH terms for substance disorders, , treatment was undertaken identify relevant randomized controlled trials RCT s). The studies were independently evaluated ILP TLS those that efficacy individuals diagnosed with s selected. Studies grouped in 3 categories: (i) first‐line (ii) medications target (iii) hypothesized be effective targeting consumption as well symptoms. Nine identified; focused treat 4 both. One study included both medication 1 so discussed twice. All but found symptoms drinking outcomes improved significantly over time. There not agent clear evidence this comorbid group. results are inconclusive because contradictory results. weak support among Findings disorders also contradictory. Most provided combination interventions disorders. Despite results, suggests can safely prescribed used noncomorbid populations patients improve treatment.

Язык: Английский

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The 7-factor hybrid model of DSM-5 PTSD symptoms and alcohol consumption and consequences in a national sample of trauma-exposed veterans

Journal of Anxiety Disorders, Год журнала: 2017, Номер 51, С. 14 - 21

Опубликована: Авг. 6, 2017

Язык: Английский

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A pilot, randomized clinical trial: Left dorsolateral prefrontal cortex intermittent theta burst stimulation improves treatment outcomes in veterans with alcohol use disorder

Alcohol Clinical and Experimental Research, Год журнала: 2024, Номер 48(1), С. 164 - 177

Опубликована: Янв. 1, 2024

Abstract Background Transcranial magnetic stimulation (TMS) offers a promising treatment avenue to modulate brain function in alcohol use disorder (AUD). To the best of our knowledge, this pilot study is first randomized, double‐blind, sham‐controlled trial deliver intermittent theta burst left dorsolateral prefrontal cortex (DLPFC) among US veterans with AUD. We hypothesized that 20 sessions real TMS are tolerable and feasible. As secondary line inquiry, we that, relative sham TMS, individuals receiving would experience greater reductions 6‐month relapse rates, anhedonia, cue‐reactivity. Methods Veterans ( n = 17, one woman) were enrolled (2–3 sessions/day; 7–10 days; 600 pulses/session; sessions). Pre‐ posttreatment assessments included responses self‐report questionnaires functional resonance imaging measures Alcohol consumption was assessed for 6 months. Linear mixed‐effects models constructed predict craving, mood, Results Individuals who received active iTBS 8) less likely within 3 months after than sham‐treated group 9) (OR 12.0). Greater anhedonia observed following (Cohen's d −0.59), −0.25). cue‐reactivity reduced increased insula −0.19 vs. 0.51), thalamus −0.28 0.77), right 0.18 0.52), −0.06 0.62). Conclusions Relative sham, demonstrate DLPFC likelihood at least The potential utility approach underscored by decreases cue‐reactivity—strong predictors veterans. These initial data offer valuable set effect sizes inform future clinical trials patient population.

Язык: Английский

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Mental Health Consequences of War Conflicts

Advances in Psychiatry, Год журнала: 2018, Номер unknown, С. 281 - 304

Опубликована: Июль 6, 2018

Modern war conflicts, evolutionizing from large-scale collisions of armed forces to local, low-intensity, surrogate, terroristic and information wars, are associated with less direct mortality but growing long-lasting mental health consequences. These consequences can be traced in not only combatants other military contingents veterans even greater extent the civilian populations, given that many modern conflicts have signs civil wars or religious conflicts. While active duty undergo preliminary selection resilience training, civilians zone as refugees asylum-seeking victims at higher risk probability transgenerational transmission, which implies (decades) effects. Both suffer a similar set disorders psychological caused by extreme trauma, including PTSD, depression, anxiety, addictions, somatization chronic pain, dissociation, psychosocial dysfunctions, suicidal behavior, etc. War acts, amplified technologically developing mass media, internet social networks, seem add general feeling instability promote more covering wider worldwide. Military psychiatry has accumulated knowledge practical experience that, though always applied directly, useful for identification, management, prevention, treatment contingents. This is one relevant strong reason advocating lowering international tension reducing worldwide sake preserving humanity. It also potential burden this type diseases

Язык: Английский

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Efficacy and acceptability of mindfulness-based interventions for military veterans: A systematic review and meta-analysis

Journal of Psychosomatic Research, Год журнала: 2020, Номер 138, С. 110232 - 110232

Опубликована: Авг. 29, 2020

Язык: Английский

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The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions

Frontiers in Psychiatry, Год журнала: 2020, Номер 11

Опубликована: Дек. 9, 2020

United States (U.S.) veterans are substantially older than their non-veteran counterparts. However, nationally representative, population-based data on the unique health needs of this population lacking. Such critical to informing design large-scale outreach initiatives, and ensure effectiveness service care delivery both within outside Veterans Affairs healthcare system. The National Health Resilience in Study (NHRVS) is a contemporary, prospective study two independent cohorts ( n = 3,157 1,484) U.S. veterans, which examining longitudinal changes, key risk protective factors for several outcomes. In narrative review, we summarize main findings all NHRVS studies 82) published as June 2020, discuss clinical implications, limitations, future directions study. Review these articles was organized into six major topic areas: post-traumatic stress disorder, suicidality, aging, resilience growth, special topics relevant genetics epigenetics. Collectively, results suggest that while significant minority screen positive mental disorders, majority psychologically resilient. They further prevention treatment efforts designed promote psychosocial characteristics (i.e., resilience, gratitude, purpose life), social connectedness secure attachment, community integration, engagement) help mitigate psychological growth population.

Язык: Английский

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Rethinking gender differences: An investigation of comorbid psychopathology and alcohol use disorder in veterans

Alcohol Clinical and Experimental Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Abstract Background While men have been found to drink more alcohol and higher rates of alcohol‐related mortality, women tend experience consequences, including psychological comorbidities worse use disorder (AUD) outcomes. However, gender differences in comorbid psychopathology associations with AUD outcomes among veterans are less well understood. Methods Veterans ( N = 126; 32 women) receiving inpatient treatment for completed baseline clinical measures the Beck Depression Inventory‐II, Anxiety Inventory, Early Life Stress Questionnaire, PTSD Checklist DSM‐5. Alcohol was assessed Timeline Followback 90 days prior assessment again at 1‐, 3‐, 6‐month follow‐ups. Gender were examined using Fisher's exact test Mann–Whitney U test. Linear/logistic regression used examine between relapse/use severity post‐study. Results Consistent literature, statistically significant observed, reporting anxiety p < 0.001), depression early life stress 0.001) baseline. Higher also associated anxiety, depression, PTSD. Statistically not observed study. Similarly, relapse or follow ups s > 0.05). Psychopathology any time point Conclusion Our study highlights that drinking similar quantities men, supporting emerging evidence a narrowing gap use. Women psychiatric burden than men; thus, identifying ways mitigate comorbidity should be health priority.

Язык: Английский

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