Preeclampsia biomarkers (sFlt-1/PlGF) dynamics are not disrupted by SARS-CoV-2 infection during pregnancy in a hypertensive disorder SARS-CoV-2 vaccinated cohort
Pregnancy Hypertension,
Год журнала:
2025,
Номер
39, С. 101196 - 101196
Опубликована: Янв. 31, 2025
Язык: Английский
Evaluating the safety and efficacy of nirmatrelvir-ritonavir therapy in pregnant women with COVID-19: a systematic review and meta-analysis
Omar A Hassan,
Aya Abdulkarim Elbhairy,
Aya Magdy Siam
и другие.
European Journal of Clinical Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Язык: Английский
Single-nucleus transcriptional profiling of the placenta reveals the syncytiotrophoblast stress response to COVID-19
American Journal of Obstetrics and Gynecology,
Год журнала:
2025,
Номер
232(4), С. S160 - S175.e7
Опубликована: Апрель 1, 2025
COVID-19
in
pregnancy
is
associated
with
placental
immune
activation,
inflammation,
and
vascular
malperfusion,
but
its
impact
on
syncytiotrophoblast
biology
function
unclear.
This
study
aimed
to
determine
the
effects
of
maternal
syncytiotrophoblasts
using
single-nucleus
transcriptional
profiling
compare
stress
responses
preeclampsia.
For
characterization
syncytiotrophoblasts,
we
used
RNA
sequencing
platform,
single-cell
combinatorial
indexing
(sci-RNA-seq3),
profile
villi
fetal
membranes
from
unvaccinated
patients
symptomatic
at
birth
(n
=
4),
gestational
age-matched
controls
a
case
critical
second
trimester
delivery
term
1).
Clustering
nuclei
differential
gene
expression
analysis
was
performed
Seurat.
Gene
ontology
conducted
Enrichr.
High-confidence
target
identify
key
transcription
factor
nodes
governing
response
SARS-CoV-2
infection.
Bioinformatic
approaches
were
further
dataset
published
preeclampsia
signatures.
Tissue
analysis,
including
immunofluorescence,
validate
data
histology
for
an
expanded
cohort
placentas:
6),
asymptomatic
3),
5),
severe
features
7).
The
analyzed
comprised
15
cell
clusters
47,889
nuclei.
We
identified
3
representing
fusing
mature
overlapping
distinct
COVID-19.
analyses
indicated
that
following
alterations
syncytiotrophoblasts:
(1)
endoplasmic
reticulum
activation
signaling
pathways,
unfolded
protein
integrated
response;
(2)
regulation
by
CCAAT/enhancer-binding
beta
(CEBPB),
master
lineage;
(3)
upregulation
preeclampsia-associated
genes.
Using
complementary
methods,
confirmed
increased
levels
proteins
(eg,
BiP,
G3BP1)
(spliced
XBP1
mRNA),
CEBPB
(phosphorylation)
Increased
cytotrophoblast
proliferation
(Ki-67)
also
detected
COVID-19,
consistent
trophoblast
injury.
Markers
demonstrated
similarities
phenotype
Maternal
lineage
factor,
CEBPB.
Similarities
between
provide
insights
into
their
clinical
association.
Язык: Английский
Placentas from SARS-CoV-2 infection during pregnancy exhibit foci of oxidative stress and DNA damage
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 25, 2024
ABSTRACT
Problem
COVID-19
during
pregnancy
is
linked
to
increased
maternal
morbidity
and
a
higher
incidence
of
preterm
births,
yet
the
underlying
mechanisms
remain
unclear.
Cellular
senescence,
characterized
by
irreversible
cessation
cell
division,
critical
process
in
placental
function
its
dysregulation
has
been
implicated
complications
like
birth.
Senescence
can
be
induced
various
stressors,
including
oxidative
stress,
DNA
damage,
viral
infections.
Method
Study
In
this
study,
we
determined
whether
had
an
impact
on
senescence.
We
examined
placentas
from
women
infected
with
SARS-CoV-2
(n=10
term,
4
preterm)
compared
uninfected
controls
3
preterm).
The
were
analyzed
for
infection/replication
(Spike
Nucleocapsid
proteins),
markers
damage
(γH2AX)
stress
(ROS),
senescence
(telomere
length;
cycle
regulators,
SASP).
Results
While
no
overall
differences
cellular
observed
between
positive
negative
groups,
found
secreted
SASP
confocal
microscopy
revealed
localized
areas
cases.
Conclusions
These
findings
indicate
that
infection
induces
warranting
further
investigation
into
perinatal
outcomes.
Язык: Английский
Expression of the mucin-like glycoprotein CD24 and its ligand siglec-10 in placentas with acute and post SARS-CoV-2 infection
Marina Seefried,
Johanna Mittelberger,
Manuela Franitza
и другие.
Journal of Reproductive Immunology,
Год журнала:
2024,
Номер
167, С. 104400 - 104400
Опубликована: Ноя. 27, 2024
Язык: Английский
Placentas From SARS‐CoV‐2 Infection During Pregnancy Exhibit Foci of Oxidative Stress and DNA Damage
American Journal of Reproductive Immunology,
Год журнала:
2024,
Номер
93(1)
Опубликована: Дек. 30, 2024
COVID-19
during
pregnancy
is
linked
to
increased
maternal
morbidity
and
a
higher
incidence
of
preterm
births
(PTBs),
yet
the
underlying
mechanisms
remain
unclear.
Cellular
senescence,
characterized
by
irreversible
cessation
cell
division,
critical
process
in
placental
function,
its
dysregulation
has
been
implicated
complications
like
PTB.
Senescence
can
be
induced
various
stressors,
including
oxidative
stress,
DNA
damage,
viral
infections.
Язык: Английский