Опубликована: Март 1, 2023
Lifshitz A.La expresión "salud" cuando se brinda o estornuda, es un buen deseo de que el prójimo sea saludable y, tal vez, estornudo no signifique resfrío.(¿Por qué desea salud, por ejemplo, también después una evacuación diarréica?)La medicina y la cultura tienen espacios compartidos atisban mundo extenso complejo apenas esbozado aquí, pero encuentra en centro mismo profesión médica su función social.
EClinicalMedicine, Год журнала: 2023, Номер 59, С. 101936 - 101936
Опубликована: Апрель 25, 2023
Язык: Английский
Процитировано
329
Allergy, Год журнала: 2022, Номер 77(5), С. 1418 - 1449
Опубликована: Фев. 2, 2022
Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.
Язык: Английский
Процитировано
268
Nature Reviews Earth & Environment, Год журнала: 2022, Номер 3(10), С. 633 - 651
Опубликована: Июль 26, 2022
Язык: Английский
Процитировано
239
Allergy, Год журнала: 2021, Номер 76(11), С. 3383 - 3389
Опубликована: Авг. 11, 2021
Allergic rhinitis (AR) is a growing public health, medical and economic problem worldwide. The current review describes the major discoveries related to AR during past 2 years, including risk factors for prevalence of AR, corresponding diagnostic strategy, precise underlying immunological mechanisms, efficient therapies ongoing global "coronavirus disease 2019" (COVID-19) pandemic. further attempts highlight future research perspectives. Increasing evidence suggests that environmental exposures, climate changes, lifestyle are important AR. Consequently, detailed investigation exposome connection between exposures health in should provide better profiles instead single predictors, also help mitigate adverse outcomes allergic diseases. Although patients with dual newly defined phenotype, display perennial seasonal allergens-related nasal symptoms, they only allergens, indicating importance measuring inflammation at local sites. Herein, we suggest combination diagnosis sites traditional methods may enhance precision medicine-based approach management AR; however, this awaits investigations. Apart from treatments, social distancing, washing hands, disinfection required manage COVID-19 Despite recent advances understanding immune mechanisms effects allergen immunotherapy (AIT), changes cell after AIT accurately evaluate efficacy required.
Язык: Английский
Процитировано
185
Pediatric Allergy and Immunology, Год журнала: 2023, Номер 34(S28)
Опубликована: Март 1, 2023
Abstract Since the discovery of immunoglobulin E (IgE) as a mediator allergic diseases in 1967, our knowledge about immunological mechanisms IgE‐mediated allergies has remarkably increased. In addition to understanding immune response and clinical symptoms, allergy diagnosis management depend strongly on precise identification elicitors reaction. past four decades, innovations bioscience technology have facilitated production well‐defined, highly pure molecules for component‐resolved (CRD), allowing personalized disease individual patients. The first edition “EAACI Molecular Allergology User's Guide” (MAUG) 2016 rapidly became key reference clinicians, scientists, interested readers with background allergology, immunology, biology, medicine. Nevertheless, field molecular allergology is moving fast, after 6 years, new EAACI Taskforce was established provide an updated document. Guide 2.0 summarizes state‐of‐the‐art information allergen molecules, their relevance, application diagnostic algorithms practice. It designed both, clinicians guiding health care professionals through overwhelming list different available testing. Further, it provides relevance allergenic gives overview basic test formats, tests measure exposure.
Язык: Английский
Процитировано
159
Nature Communications, Год журнала: 2022, Номер 13(1)
Опубликована: Март 15, 2022
Atmospheric conditions affect the release of anemophilous pollen, and timing magnitude will be altered by climate change. As simulated with a pollen emission model future data, warmer end-of-century temperatures (4-6 K) shift start spring emissions 10-40 days earlier summer/fall weeds grasses 5-15 later lengthen season duration. Phenological shifts depend on temperature response individual taxa, convergence in some regions divergence others. Temperature precipitation alter daily maxima -35 to 40% increase annual total 16-40% due changes phenology temperature-driven production. Increasing atmospheric CO
Язык: Английский
Процитировано
150
The Science of The Total Environment, Год журнала: 2023, Номер 898, С. 166340 - 166340
Опубликована: Авг. 15, 2023
Язык: Английский
Процитировано
144
Allergy, Год журнала: 2021, Номер 76(11), С. 3390 - 3407
Опубликована: Авг. 15, 2021
Last year brought a significant advance in asthma management, unyielding to the pressure of pandemics. Novel key findings pathogenesis focus on resident cell compartment, epigenetics and innate immune system. The precision immunology unbiased approach was supplemented with novel tools greatly facilitated by use artificial intelligence. Several randomised clinical trials good quality real-world evidence shed new light treatment supported revision several guidelines (GINA, Expert Panel Report 3, ERS/ATS severe asthma) conception ones (EAACI Guidelines for biologicals asthma). Integrating management within broader context Planetary Health has been put forward. In this review, recently published articles are summarised discussed goal provide clinicians researchers concise update research from translational perspective.
Язык: Английский
Процитировано
126
Allergy, Год журнала: 2022, Номер 77(5), С. 1389 - 1407
Опубликована: Янв. 24, 2022
There is increasing understanding, globally, that climate change and increased pollution will have a profound mostly harmful effect on human health. This review brings together international experts to describe both the direct (such as heat waves) indirect vector-borne disease incidence) health impacts of change. These vary depending vulnerability (i.e., existing diseases) international, economic, political, environmental context. unique also expands these issues address third category potential longer-term global health: famine, population dislocation, justice education. scholarly resource explores fully, linking them in urban rural settings developed developing countries. The finishes with practical discussion action professionals around world our field can yet take.
Язык: Английский
Процитировано
108
Deleted Journal, Год журнала: 2024, Номер unknown
Опубликована: Июнь 1, 2024
Interactions between humans and the physical environment in which they live have been studied extensively reason being that human activities to a great extent exert an influence on (biotic abiotic). Pollution other hand is introducing harmful substances into are damaging living organisms. Pollutants can be gases, liquids or solids produced concentrations higher than usual diminish quality of environment. Human adverse effects by polluting air we breathe, water drink even cause climatic changes. In terms provision manifold services, technology societal modernization, industrial revolution recorded outstanding success, it however, was beginning mass production pollutants emitted caused health our era, industrialization urbanization evidently reaching unprecedented disturbing proportions globally with anthropogenic pollution one major public hazards, accounting for almost 9 million deaths annually. This research therefore aims investigate environmental from activities, particularly water, climate change provide comprehensive understanding interconnectedness their consequences. Furthermore, since emerges as global concern developing countries; this study thus also highlights significance efficient wastewater treatment crucial strategy sustainable development, exploring its potential contribution mitigation.
Язык: Английский
Процитировано
66