A pathogenic integrated view explaining the different endotypes of asthma and allergic disorders DOI
Enrico Maggi, Paola Parronchi, Bruno Azzarone

и другие.

Allergy, Год журнала: 2022, Номер 77(11), С. 3267 - 3292

Опубликована: Июль 17, 2022

The inflammation of allergic diseases is characterized by a complex interaction between type 2 and 3 immune responses, explaining clinical symptoms histopathological patterns. Airborne stimuli activate the mucosal epithelium to release number molecules impacting activity resident environmental cells. Signals from barrier, regulatory cells, inflamed tissue are crucial conditions able modify innate adaptive effector cells providing selective homing eosinophils or neutrophils. high plasticity T- lymphoid responding external signals prerequisite explain multiplicity endotypes diseases. This notion paved way for huge use specific biologic drugs interfering with pathogenic mechanisms inflammation. Based on response epithelial functions structural non-lymphoid this review proposes some immunopathogenic scenarios characterizing principal which can be associated precise phenotype asthma. Recent literature indicates that similar concepts also applied other non-respiratory disorders. next challenges will consist in defining biomarker(s) each endotype allowing quick diagnosis most effective personalized therapy.

Язык: Английский

B lymphocytes ameliorate Alzheimer’s disease-like neuropathology via interleukin-35 DOI
Weixi Feng, Yanli Zhang, Shixin Ding

и другие.

Brain Behavior and Immunity, Год журнала: 2022, Номер 108, С. 16 - 31

Опубликована: Ноя. 24, 2022

Язык: Английский

Процитировано

35
Regulatory T cells and immunoglobulin E: A new therapeutic link for autoimmunity? DOI
Óscar Palomares, Dirk Elewaut, Peter M. Irving

и другие.

Allergy, Год журнала: 2022, Номер 77(11), С. 3293 - 3308

Опубликована: Июль 19, 2022

Abstract Autoimmune diseases have a prevalence of approximately 7 to 9% and are classified as either organ‐specific diseases, including type I diabetes, multiple sclerosis, inflammatory bowel disease myasthenia gravis, or systemic lupus erythematosus, rheumatoid arthritis Sjögren's syndrome. While many advancements been made in understanding the mechanisms autoimmune disease, nature self‐tolerance its breakdown, there remain unmet needs terms effective highly targeted treatments. T regulatory cells (Tregs) key mediators peripheral tolerance implicated result reduced numbers altered function. Tregs may be broadly divided into those generated thymus (tTregs) periphery (pTregs). target different immune cell subsets tissues suppress excessive inflammation support tissue repair homeostasis: is fine balance between Treg stability plasticity that required adjust Tregs' purposes particular responses. The central role immunoglobulin E (IgE) allergic well recognized, it becoming increasingly apparent this also has wider encompassing other disease. Anti‐IgE treatment restores capacity plasmacytoid dendritic (pDCs) impaired by IgE‐ high‐affinity IgE receptor (FcεR1) cross‐linking induce vitro atopic patients. finding anti‐IgE therapy homeostasis, mechanism associated with clinical improvement asthma chronic spontaneous urticaria suggests potential which involved.

Язык: Английский

Процитировано

34
Immune signatures predict response to house dust mite subcutaneous immunotherapy in patients with allergic rhinitis DOI
Nan Wang, Jia Song,

Shi‐Ran Sun

и другие.

Allergy, Год журнала: 2024, Номер 79(5), С. 1230 - 1241

Опубликована: Фев. 25, 2024

Identifying predictive biomarkers for allergen immunotherapy response is crucial enhancing clinical efficacy. This study aims to identify such in patients with allergic rhinitis (AR) undergoing subcutaneous (SCIT) house dust mite allergy.

Язык: Английский

Процитировано

9
Intratumoral CD38+CD19+B cells associate with poor clinical outcomes and immunosuppression in patients with pancreatic ductal adenocarcinoma DOI Creative Commons

Heng Zhu,

Jin Xu, Wei Wang

и другие.

EBioMedicine, Год журнала: 2024, Номер 103, С. 105098 - 105098

Опубликована: Апрель 11, 2024

BackgroundThe widespread involvement of tumor-infiltrating B cells highlights their potential role in tumor behavior. However, cell heterogeneity PDAC remains unexplored. Studying TIL-Bs aims to identify new treatment strategies.MethodsWe performed single-cell RNA sequencing study the PDAC. The prognostic and immunologic value identified CD38+ was explored FUSCC (n = 147) TCGA 176) cohorts. Flow cytometry conducted characterize relationship between other immune cells, as well phenotypic features. In vitro vivo experiments were assess putative effect on antitumor immunity.FindingsThe presence associated with unfavorable clinicopathological features poorer overall survival (p < 0.001). Increased infiltration accompanied by reduced natural killer (NK) 0.021) increased regulatory T 0.016). Molecular profiling revealed high expression IL-10, IL-35, TGF-β, GZMB, TIM-1, CD5 CD21, confirming cell-like Co-culture demonstrated suppression NK cytotoxicity cell-derived IL-10 Finally, suggested adoptive transfer immunity administration a CD38 inhibitor hampered growth 0.001).InterpretationWe discovered an independent factor use may provide possibilities for immunotherapy.FundingThis supported National Natural Science Foundation China (U21A20374), Shanghai Municipal Technology Major Project (21JC1401500), Scientific Innovation Education Committee (2019-01-07-00-07-E00057), Special Clinical Research Health Industry Commission (No. 20204Y0265) (23ZR1479300).

Язык: Английский

Процитировано

9
The role of regulatory B cells in immune regulation and childhood allergic asthma DOI Creative Commons
C Kliem, Bianca Schaub

Molecular and Cellular Pediatrics, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 4, 2024

Abstract Background As the most common chronic disease in childhood, asthma displays a major public health problem worldwide with incidence of those affected rising. there is currently no cure for allergic asthma, it mandatory to get better understanding underlying molecular mechanism. Main body By producing IgE antibodies upon allergen contact, B cells play pivotal role asthma. Besides that, IL-10-secreting cell subsets, namely regulatory (Bregs), are reported mice and humans In humans, several Breg subsets distinct phenotypic functional properties identified among at different maturational differentiation stages that exert anti-inflammatory functions by expressing suppressor molecules. Emerging research has focused on Bregs as well their future diagnostic preventive strategies. Conclusion Knowledge about exact function human still very limited. This review aims summarize current knowledge Bregs. We discuss ways induction mechanisms through which they immunoregulatory functions, (childhood)

Язык: Английский

Процитировано

7
Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression DOI
Rebeca T. Stiepel, Sean R. Simpson, Nicole Rose Lukesh

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Multiple sclerosis (MS) is a severe autoimmune disorder that wreaks havoc on the central nervous system, leading to spectrum of motor and cognitive impairments. There no cure, current treatment strategies rely broad immunosuppression, leaving patients vulnerable infections. To address this problem, our approach aims induce antigen-specific tolerance, much-needed shift in MS therapy. We have engineered tolerogenic therapy consisting spray-dried particles made degradable biopolymer, acetalated dextran, loaded with an antigenic peptide tolerizing drug, rapamycin (Rapa). After initial characterization optimization, were tested myelin oligodendrocyte glycoprotein (MOG)-induced experimental encephalomyelitis model MS. Representing earliest possible time diagnosis, mice treated at symptom onset early therapeutic model, where containing MOG Rapa+MOG evoked significant reductions clinical score. Particles then applied highly clinically relevant late during peak disease, each elicited dramatic effect, reversing hind limb paralysis restoring fully functional limbs. confirm antigen specificity therapy, we immunized against influenza hemagglutinin (HA) them or particles. The did not suppress antibody responses HA. Our findings underscore potential particle-based reverse autoimmunity disease-relevant models without compromising immune competence, setting it apart from existing treatments.

Язык: Английский

Процитировано

1
Features of B Cell Responses Relevant to Allergic Disease DOI Open Access
Christopher D.C. Allen

The Journal of Immunology, Год журнала: 2022, Номер 208(2), С. 257 - 266

Опубликована: Янв. 11, 2022

Abstract This Brief Review delves into B cell responses in the context of allergy. The primary contribution cells to allergy is production IgE, Ab isotype that triggers immediate hypersensitivity reactions through release mediators from mast and basophils. may also have protective roles allergy, such as IgG or regulatory cells. In this review, I focus on basic principles differentiation discuss features relevant allergic immune responses. particular, discuss: (1) class-switch recombination; (2) plasma differentiation; (3) germinal centers affinity maturation; (4) memory recall responses, with an emphasis IgG1, IgG4. consider how contribute independent production—for example, by serving APCs.

Язык: Английский

Процитировано

28
B cells: The many facets of B cells in allergic diseases DOI
Pattraporn Satitsuksanoa,

Sayuri Iwasaki,

Jolien Boersma

и другие.

Journal of Allergy and Clinical Immunology, Год журнала: 2023, Номер 152(3), С. 567 - 581

Опубликована: Май 27, 2023

Язык: Английский

Процитировано

17
B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3 DOI
Guojun Qian, Wenxia Jiang, Donglin Sun

и другие.

Cellular and Molecular Immunology, Год журнала: 2023, Номер 20(11), С. 1313 - 1327

Опубликована: Авг. 31, 2023

Язык: Английский

Процитировано

15
Exploring the dual role of B cells in solid tumors: implications for head and neck squamous cell carcinoma DOI Creative Commons
Jiantong Bao, Annika Betzler, Jochen Heß

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Окт. 5, 2023

In the tumor milieu of head and neck squamous cell carcinoma (HNSCC), distinct B subpopulations are present, which exert either pro- or anti-tumor activities. Multiple factors, including hypoxia, cytokines, interactions with cells, other immune infiltrating lymphocytes (TILs), alter equilibrium between dual roles cells leading to cancerogenesis. Certain subsets in microenvironment (TME) exhibit immunosuppressive function. These known as regulatory (Breg) cells. Breg suppress responses by secreting a series IL-10, IL-35, TGF-β, granzyme B, adenosine dampen effector TILs intercellular contacts. phenotypes have been discovered human mouse cancer models. However, when compartmentalized within tertiary lymphoid structure (TLS), predominantly play effects. A mature TLS contains CD20 + zone several important types germinal-center like antibody-secreting plasma memory They kill via antibody-dependent cytotoxicity phagocytosis, local complement activation TLSs also privileged sites for T coordination activation. Nonetheless, some cases, may serve niche hidden indicate bad prognosis. Thus, TIL-B bidirectional immune-modulatory activity responsive variety immunotherapies. this review, we discuss functional distinctions immunogenic that focus on tumors HNSCC patients. Additionally, review contemporary immunotherapies aim target For development innovative therapeutic approaches T-cell-based immunotherapy, full understanding is necessary.

Язык: Английский

Процитировано

15