Allergy, Год журнала: 2023, Номер 78(6), С. 1419 - 1421

Опубликована: Март 25, 2023

It has now been over 3 years since the coronavirus disease 2019 (COVID-19) was declared a global pandemic, and its end appears to be in sight. Governmental restrictions imposed during pandemic are gradually softening. In early 2023, China also changed epidemic prevention policy academic exchanges returning normal. This reminds us of first step understanding role allergy susceptibility prognosis COVID-19, provided by Chinese scholars Wuhan. Zhang colleagues1 characterized 140 hospitalized subjects with COVID-19 (admission date from January 16 February 3, 2020), demonstrated that allergic diseases asthma were not risk factors for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. study subsequently become one most cited articles Allergy. directed focus numerous studies improve our relationship between SARS-CoV-2 infection diseases. published on 19, 2020 online as paper reporting human contact, clinical laboratory aspects groups COVID-19.1 this regard, have committed vast resources time understand pathophysiology coronavirus. Prime examples Cao colleagues,2-4 which emergence evolution variants recently top-tier journals such Cell Nature.2-4 Despite many persistently conducted research The latest progress contributions these “epithelial barrier theory” gateway diseases, allergen recognition, promising treatments highlighted special “China Issue” Allergy (Figure 1). Indeed, intact skin mucosal barriers play crucial protecting host tissues against infections, pollutants, allergens.5 Environmental exposure toxic substances, epithelial damage, activation cells, release alarmins, local systemic immune response, bacterial dysbiosis, loss biodiversity commensals involved development causing damage.5, 6 context，a recent low-latitude multi-city increases air pollutant concentrations changes meteorological conditions (temperature, humidity, wind speed) might associated number outpatient visits rhinitis (AR).7 Accordingly, addressing both pollution climate change imposing strict governmental policies lower incidence decrease long-lasting health effects.8 lipids sebaceous glands dysfunction atopic dermatitis (AD) under-recognized. Yin colleagues9 noticed aberrant lipid metabolism correlated inflammation dysfunction, contributed pathogenesis AD. Another group indicated CST1 protein suppressed symptoms asthmatic bronchial through inhibiting allergenic protease activity, indicating potential biomarker control.10 “allergic march” AD and/or AR later life well extensive comorbidity disorders frequently observed real life. Data real-life investigating effectiveness dupilumab patients different ages suggest pediatric may respond significantly greater level than adults.11 Whether function status infants versus adults or intervention at “leaky barrier” an stage beneficial adverse consequences, remains open question warrants further research. Yang colleagues expounded two possible pathways contributing pollen’s effect using multiple-adjusted generalized additive (GAM) model.12 Besides recognizing features allergy,13 knowing allergen-encoding genes their isoforms chromosomal help detect novel allergens.14 Zhao identified three well-recognized mango fruit molecules combined omics tools immunological methods. authors showed can used component-resolved diagnosis spiked into extract diagnostic efficacy.15 terms treatments, especially asthma, more Liang circS100A11 S100A11 promoted M2a macrophage lung murine model children suggesting therapeutic target asthma.16 Employing model, Sun Fedratinib-incorporated nanoparticles overcome shortcomings free Fedratinib alleviate reducing eosinophils CD4+ T cells tissue animals.17 More recently, multicenter prospective Gao suggested pre-schoolers, standard childhood vaccinations common pathogens, including Haemophilus influenzae, Streptococcus pneumoniae, influenza, effects control modulate responses relevant pathogenesis.18 Reportedly, microglia enhance GRPR+neurons NLRP3/caspase-1/IL-1β/IL1R1 axis, providing strategies chronic itch.19 Huang reported arsenic pruritus β-endorphin served pruritus. Besides, naloxone could relieve due arseniasis.20 Wang colleague summmarized mesenchymal stem (MSCs) airway disease, bringing new view treatment.21 addition, Liao's data supported application thermally modified MC-derived exosomes treatment diseases.22 Hopefully, achievements issue will provide directions overall framework lead international cooperation communication problems. C. A. Akdis received grants Swiss National Science Foundation, European Union (EU CURE, EU Syn-Air-G), Novartis Research Institutes, (Basel, Switzerland), Stanford University (Redwood City, Calif), Seed Health (Boston, USA), SciBase (Stockholm, Sweden); is Co-Chair EAACI Guidelines Allergic Asthma; Chair Epithelial Biology Working Group Advisory Boards Sanofi/Regeneron (Bern, Switzerland, New York, Sean Parker Asthma Center (CA, Glaxo Smith Kline (Zurich, Bristol-Myers Squibb (New Editor-in-Chief

Язык: Английский