Bioinformatic Analysis of Key Regulatory Genes in Adult Asthma and Prediction of Potential Drug Candidates DOI Creative Commons
Shaojun Chen,

Jiahao Lv,

Luo Yiyuan

и другие.

Molecules, Год журнала: 2023, Номер 28(10), С. 4100 - 4100

Опубликована: Май 15, 2023

Asthma is a common chronic disease that characterized by respiratory symptoms including cough, wheeze, shortness of breath, and chest tightness. The underlying mechanisms this are not fully elucidated, so more research needed to identify better therapeutic compounds biomarkers improve outcomes. In present study, we used bioinformatics analyze the gene expression adult asthma in publicly available microarray datasets putative molecules for disease. We first compared healthy volunteers patients obtain differentially expressed genes (DEGs) further analysis. A final signature 49 genes, 34 upregulated 15 downregulated was obtained. Protein-protein interaction hub analyses showed 10 POSTN, CPA3, CCL26, SERPINB2, CLCA1, TPSAB1, TPSB2, MUC5B, BPIFA1, CST1, may be genes. Then, L1000CDS2 search engine drug repurposing studies. top approved candidate predicted reverse lovastatin. Clustergram results lovastatin perturb MUC5B expression. Moreover, molecular docking, dynamics simulation, computational alanine scanning supported notion interact with via key residues such as Thr80, Thr91, Leu93, Gln105. summary, analyzing signatures, perturbation, show an have potential treating asthma.

Язык: Английский

Effect of air pollution on asthma DOI Creative Commons
Xiaoying Zhou, Vanitha Sampath, Kari C. Nadeau

и другие.

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер 132(4), С. 426 - 432

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

28
Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell DOI Creative Commons

Simone E. M. Olsthoorn,

Anneloes van Krimpen, Rudi W. Hendriks

и другие.

Immunological Reviews, Год журнала: 2025, Номер 330(1)

Опубликована: Фев. 27, 2025

ABSTRACT Asthma is a common chronic inflammatory disease of the airways. A substantial number patients present with severe and therapy‐resistant asthma, for which underlying biological mechanisms remain poorly understood. In most asthma patients, airway inflammation characterized by activation type 2 immunity. CD4 + T helper (Th2) cells are canonical producers cytokines that fuel inflammation: interleukin (IL)‐4, IL‐5, IL‐9, IL‐13. However, more recent findings have shown other lymphocyte subsets, in particular group innate lymphoid (ILC2s) CD8 cytotoxic (Tc2) cells, can also produce large amounts cytokines. Importantly, inflammation, despite high sensitivity Th2 suppression corticosteroids—the mainstay drugs asthma. Emerging evidence indicates ILC2s Tc2 abundant adopt corticosteroid‐resistance states. Moreover, many do not overt implicating non‐type immunity as driver disease. this review, we will discuss pathophysiology focus on roles played ILC2s, lymphocytes, placing special emphasis forms.

Язык: Английский

Процитировано

3
Advances in the Relationship between Respiratory Viruses and Asthma DOI Open Access
Sergio de Jesús Romero Tapia,

Crystell Guzmán Priego,

Blanca E. Del-Río-Navarro

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(17), С. 5501 - 5501

Опубликована: Авг. 24, 2023

Several studies have reported that viral infection is closely associated with the onset, progression, and exacerbation of asthma. The purpose this review to summarize role infections in pathogenesis asthma onset exacerbations, as well discuss interrelated protective risk factors current treatment options. Furthermore, we present knowledge innate immunological pathways driving host defense, including changes epithelial barrier. In addition, highlight importance genetics epigenetics virus susceptibility. Moreover, involvement etiology from bronchiolitis childhood wheezing described. characterization mechanisms action respiratory viruses most frequently related are mentioned.

Язык: Английский

Процитировано

15
Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma DOI Creative Commons
Glenis Scadding, Marinda McDonald, Vibeke Backer

и другие.

Frontiers in Allergy, Год журнала: 2024, Номер 4

Опубликована: Янв. 30, 2024

Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers society. It the most common chronic disease children represents one of major causes for years lived with disability. Significant efforts are made by organizations such as WHO improving diagnosis, treatment monitoring asthma. However asthma prevention has been less studied. Currently there concept pre- diabetes allows reduction full blown if diet exercise undertaken. Similar predictive states found Alzheimer's Parkinson's diseases. In this paper we explore possibilities prevention, both at population level also investigate possibility defining state pre-asthma, intensive could reduce progression Since heterogeneous condition, concerned allergic A subsequent will deal late onset eosinophilic

Язык: Английский

Процитировано

6
Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways DOI Creative Commons
Bernard Stikker, Lianne Trap, Bahareh Sedaghati-khayat

и другие.

European Respiratory Journal, Год журнала: 2024, Номер 64(2), С. 2302059 - 2302059

Опубликована: Июнь 20, 2024

Individual differences in susceptibility to developing asthma, a heterogeneous chronic inflammatory lung disease, are poorly understood. Whether genetics can predict asthma risk and how genetic variants modulate the complex pathophysiology of still debated.

Язык: Английский

Процитировано

6
Omics approaches in asthma research: Challenges and opportunities DOI Creative Commons
Molin Yue,

Shiyue Tao,

K.M. Gaietto

и другие.

Chinese Medical Journal - Pulmonary and Critical Care Medicine, Год журнала: 2024, Номер 2(1), С. 1 - 9

Опубликована: Март 1, 2024

Asthma, a chronic respiratory disease with global prevalence of approximately 300 million individuals, presents significant societal and economic burden. This multifaceted syndrome exhibits diverse clinical phenotypes pathogenic endotypes influenced by various factors. The advent omics technologies has revolutionized asthma research delving into the molecular foundation to unravel its underlying mechanisms. Omics are employed systematically screen for potential biomarkers, encompassing genes, transcripts, methylation sites, proteins, even microbiome components. review provides an insightful overview applications in research, special emphasis on genetics, transcriptomics, epigenomics, microbiome. We explore cutting-edge methods, discoveries, challenges, future directions realm research. By integrating multi-omics non-omics data through advanced statistical techniques, we aspire advance precision medicine asthma, guiding diagnosis, risk assessment, personalized treatment strategies this heterogeneous condition.

Язык: Английский

Процитировано

4
Perinatal Risk Factors for Asthma and Allergic Rhinitis in Children and Adolescents DOI Creative Commons
Se Hwan Hwang, Hyesoo Shin, Gulnaz Stybayeva

и другие.

Clinical and Experimental Otorhinolaryngology, Год журнала: 2024, Номер 17(2), С. 168 - 176

Опубликована: Апрель 8, 2024

In this study, we evaluated the associations between birth-related exposures, postnatal factors, and risk of allergic rhinitis asthma in children adolescents.

Язык: Английский

Процитировано

4
A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation DOI Creative Commons
T. Kumagai, Arifumi Iwata, Hiroki Furuya

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(27)

Опубликована: Июнь 26, 2024

Asthma is a widespread airway disorder where GATA3-dependent Type-2 helper T (Th2) cells and group 2 innate lymphoid (ILC2s) play vital roles. Asthma-associated single nucleotide polymorphisms (SNPs) are enriched in region located 926-970 kb downstream from GATA3 the 10p14 (hG900). However, it unknown how hG900 affects pathogenesis of allergic inflammation. To investigate roles asthma-associated enhancer experimental inflammation, we first examined correlation between expression activation was analyzed by flow cytometry ChIP-qPCR. We found that The enhancers strongly correlated to levels human peripheral cell subsets. next generated mice lacking mG900 (mG900KO mice) were CRISPR-Cas9 system, development function ILCs mG900KO steady-state conditions inflammation induced papain or house dust mite (HDM). deletion did not affect lymphocytes papain. exhibited reduced Th2 differentiation HDM-induced analysis chromatin conformation around Gata3 circular chromosome capture coupled high-throughput sequencing (4C-seq) revealed interacted with transcription start site an influencing cells. These findings indicate plays pivotal role thus enhances

Язык: Английский

Процитировано

4
The function of antibodies DOI
Marc Daëron

Immunological Reviews, Год журнала: 2024, Номер 328(1), С. 113 - 125

Опубликована: Авг. 24, 2024

Summary Antibodies have multiple biological activities. They can both recognize and act on specific antigens. protect against cause serious diseases, enhance inhibit antibody responses, enable survival, threaten life. Which among their many, often antagonistic properties explains that antibodies were selected half a billion years ago transmitted to mammals across millions of generations? In other words, what is the function antibodies? Here I examine how structure endows with unique cognitive effector contribute show rather than properties, large functional repertoires. repertoire an are from larger available repertoires, themselves drawn at random even virtual These repertoires provide adaptive immune system immense, constantly renewed, reservoirs functions be actualized any time according context. propose such flexibility, which enables living individuals adapt rapidly changing environment, deal unknown future, may better selective advantage particular function.

Язык: Английский

Процитировано

4
YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS DOI Creative Commons
Jing Wang, Yao Zhou, Meng Zhang

и другие.

Cell Reports, Год журнала: 2024, Номер 43(3), С. 113947 - 113947

Опубликована: Март 1, 2024

N6-methyladenosine (m6A) modification has been implicated in many cell processes and diseases. YTHDF1, a translation-facilitating m6A reader, not previously shown to be related allergic airway inflammation. Here, we report that YTHDF1 is highly expressed epithelial cells asthmatic patients it influences proinflammatory responses. CLOCK, subunit of the circadian clock pathway, direct target YTHDF1. augments CLOCK translation an m6A-dependent manner. Allergens enhance liquid-liquid phase separation (LLPS) drive formation complex comprising dimeric mRNA, which distributed stress granules. Moreover, strongly activates NLRP3 inflammasome production interleukin-1β secretion leading inflammatory responses, but these phenotypes are abolished by deleting CLOCK. These findings demonstrate important regulator inflammation, suggesting potential therapeutic for

Язык: Английский

Процитировано

3