Dendritic cells in food allergy, treatment, and tolerance

Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер 154(3), С. 511 - 522

Опубликована: Июль 5, 2024

Язык: Английский

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Allergenicity and Linear Epitope Analysis of Scy p 8, an Allergen from Mud Crab

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(23), С. 13402 - 13414

Опубликована: Май 31, 2024

Scy p 8 (triosephosphate isomerase) as a crab allergen in inducing distinct T-helper (Th) cell differentiation and linear epitope associated with allergenicity remain elusive. In this study, mice sensitized exhibited significantly upregulated levels of IgE, IgG1, IL-4 release, Th2 immune response. Moreover, the release IFN-γ (Th1) Treg cells were downregulated, while IL-17A (Th17) was upregulated, indicating that disrupted Th1/Th2 balance Th17/Treg mice. Furthermore, bioinformatics prediction serum samples from crab-allergic patients enabled discovery epitopes 8. Meanwhile, analysis peptide similarity tertiary superposition revealed conservation across various species, potentially resulting cross-reactivity. These findings possess potential to enhance comprehension allergens, thereby establishing foundation for investigating

Язык: Английский

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The potential of orally exposed risk factors and constituents aggravating food allergy: Possible mechanism and target cells

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(5)

Опубликована: Сен. 1, 2024

Abstract Food allergy is a significant concern for the health of humans worldwide. In addition to dietary exposure food allergens, genetic and environmental factors also play an important role in development allergy. However, only tip iceberg risk has been identified. The importance caused by orally exposed constituents, including veterinary drugs, pesticides, processed foods/derivatives, nanoparticles, microplastics, pathogens, toxins, additives, intake salt/sugar/total fat, vitamin D, therapeutic are highlighted discussed this review. Moreover, epithelial barrier hypothesis, which closely associated with occurrence allergy, introduced. Additionally, several constituents that have reported disrupt elucidated. Finally, possible mechanisms key immune cells aggravating overviewed. Further work should be conducted define specific mechanism these driving will central targeted therapy

Язык: Английский

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T follicular helper cells in food allergy

Current Opinion in Immunology, Год журнала: 2024, Номер 91, С. 102461 - 102461

Опубликована: Сен. 14, 2024

Язык: Английский

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Air pollution is associated with persistent peanut allergy in the first 10 years

Journal of Allergy and Clinical Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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