Allergy, Год журнала: 2024, Номер 79(12), С. 3269 - 3284
Опубликована: Ноя. 1, 2024
Abstract Human skin is colonized with microbiota that includes commensal bacteria, fungi, arthropods, archaea and viruses. The composition of the varies at different anatomical locations according to changes in body temperature, pH, humidity/hydration or sebum content. A homeostatic crucial maintain epithelial barrier functions, protect from invading pathogens interact immune system. Therefore, maintaining homeostasis holds promise be an achievable goal for microbiome‐directed treatment strategies as well a prophylactic strategy prevent development diseases, dysbiosis disruption associated inflammation. healthy microbiome likely modulated by genetic environmental lifestyle factors. In this review, we aim provide complete overview factors can contribute healthy. Awareness these could basis diseases used therapeutic approach.
Язык: Английский
Процитировано
6Interventions in cytokine signaling: novel horizons for psoriasis treatment
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 15, 2025
Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, transforming growth factor-β (TGF-β), are essential for controlling cellular activity immunological responses, maintaining homeostasis contributing to the pathogenesis of psoriasis. These molecules modulate microenvironment by either promoting or suppressing inflammation, which significantly impacts therapeutic outcomes. Recent research indicates treatment strategies targeting chemokines have significant potential, offering new approaches regulating system, inhibiting progression reducing adverse effects traditional therapies. This review consolidates current knowledge on cytokine chemokine signaling pathways in psoriasis examines their significance treatment. Specific attention given like IL-17, IL-23, TNF-α, underscoring necessity innovative therapies these address processes. emphasizes principal part -pathological process explores challenges opportunities they present intervention. Furthermore, we examine recent advancements targeted therapies, with particular focus monoclonal antibodies, ongoing clinical trials.
Язык: Английский
Процитировано
0Natural products as promising therapeutics for fine particulate matter–induced skin damage: a review of pre-clinical studies on skin inflammation and barrier dysfunction
PeerJ, Год журнала: 2025, Номер 13, С. e19316 - e19316
Опубликована: Апрель 28, 2025
Particulate matter less than 2.5 µm (PM2.5) is a significant air pollutant and linked to an increased risk of health conditions, including skin diseases. The skin, as the first barrier largest organ, primarily damaged by PM2.5 through different pathways. Several studies have shown that upregulates inflammatory responses excessive production reactive oxygen species (ROS) several cytokines, leading PM2.5-induced damage. ROS/mitogen-activated protein kinase (MAPK) Cyclooxygenase-2-Prostaglandin E2 (COX2/PGE2) pathways are activated free radical scavenging phase II detoxification. Natural products been suggested therapeutic agents for mitigating We elaborate on mechanisms action natural their functions protectants against environmental This review highlights optimal doses clinical study, which may benefit dermatologists, molecular biologists, clinicians, healthcare professionals in preventive alternative medicine. available scientific literature published between 1999 2024 was searched using PubMed Google Scholar. Multiple keywords related topic were used. Only 41 screened articles chosen this review, they most relevant publications advantages specific targeting injury. All meeting criteria being original full written English included. summarized products, phenolic/polyphenolic compounds flavonoids, can act anti-inflammatory antioxidant protecting oxidative stress, inhibiting enzymes promote formation, enhancing enzyme activity, reducing overall ROS formation. demonstrated efficacy alleviating intracellular ROS, mitochondrial dysfunction, autophagy, apoptosis caused PM2.5. In addition, phytochemical support restoration wound healing process muscle contraction impaired pollutants, such UV rays. promising protect environment-mediated problems focusing action. Particular emphasis placed compounds, sulforaphane, hesperidin, quercetin, catechin, diphloroethohydroxycarmalol, resveratrol, ginsenoside, become interesting candidates nutraceuticals due potential reduce reliance conventional medicines. However, low stability bioavailability remain challenges use; therefore, further research development warranted.
Язык: Английский
Процитировано
0Skin-deep immune sensing
Cell Host & Microbe, Год журнала: 2025, Номер 33(2), С. 167 - 168
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0HIV-Associated Dermatological Alterations: Barrier Dysfunction, Immune Impairment, and Microbiome Changes
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3199 - 3199
Опубликована: Март 30, 2025
Human Immunodeficiency Virus (HIV) significantly impacts skin structure, immune responses, and the microbiome, contributing to diverse dermatological conditions. The epidermis, a key physical immunological barrier, undergoes structural changes such as hyperplasia inflammatory infiltrates. Skin adnexal structures like hair follicles also play role in modulation but are affected by HIV-related disruptions. Innate adaptive systems compromised due CD4+ T-cell depletion, cytokine imbalances, altered regulation, leading conditions hypersensitivity dermatoses. microbiome HIV patients shows distinct shifts, including reduced Cutibacterium species increased opportunistic microbes, independent of levels. Age, sex, environmental stressors exacerbate these changes, with women exhibiting stronger responses higher risks autoimmune diseases aging men experiencing accelerated immunosenescence. Understanding interconnected alterations is essential for developing targeted therapies manage complications improve overall health patients.
Язык: Английский
Процитировано
0Effect of Gut Microbiome on Skin Microbiome
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
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