Guijiajiao-Lujiaojiao Synergistically Promote Spermatogenesis in Tripterygium Wilfordii Polyglycoside–Induced Oligoasthenozoospermia Rats via PI3K/AKT Signaling Pathway DOI Creative Commons

Nianwen Huang,

Haisong Li, Longji Sun

и другие.

American Journal of Men s Health, Год журнала: 2024, Номер 18(6)

Опубликована: Ноя. 1, 2024

Guijiajiao-Lujiaojiao (GL) is a combination of Traditional Chinese Medicine (TCM) that can be used to treat oligoasthenozoospermia (OAS). However, its mechanistic role in OAS needs better understood and necessitates more studies. This study was planned investigate GL's therapeutic effects the tripterygium wilfordii polyglycoside (GTW)-induced rat model. In total, 60 Sprague-Dawley (SD) rats at 8 weeks age were assigned six groups: blank (NC), model (GTW), GL low-dose (GL-L, 0.3 g/kg/day), medium-dose (GL-M, 0.6 high-dose (GL-H, 1.2 + PI3K inhibitor LY294002 (GL-H g/kg/day LY mg/kg/day) groups. The characterized after examine sperm concentration viability, serum hormone levels, testes histopathology, specific protein markers. treatment efficacy evaluated by mRNA expression among other parameters. Compared with GTW group, viability spermatozoa significantly increased intervention (

Язык: Английский

The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies DOI

Zechen Niu,

Huanhuan Zhang,

Chunzhou Cai

и другие.

Reproductive Toxicology, Год журнала: 2025, Номер 132, С. 108830 - 108830

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0
Zinc Ameliorates Tripterygium Glycosides–Induced Reproductive Impairment in Male Rats by Regulating Zinc Homeostasis and Expression of Oxidative Stress–Related Genes DOI
Jing Ma,

He Tan,

Jiajie Bi

и другие.

Biological Trace Element Research, Год журнала: 2023, Номер 202(5), С. 2111 - 2123

Опубликована: Авг. 23, 2023

Язык: Английский

Процитировано

7
Guijiajiao-Lujiaojiao Synergistically Promote Spermatogenesis in Tripterygium Wilfordii Polyglycoside–Induced Oligoasthenozoospermia Rats via PI3K/AKT Signaling Pathway DOI Creative Commons

Nianwen Huang,

Haisong Li, Longji Sun

и другие.

American Journal of Men s Health, Год журнала: 2024, Номер 18(6)

Опубликована: Ноя. 1, 2024

Guijiajiao-Lujiaojiao (GL) is a combination of Traditional Chinese Medicine (TCM) that can be used to treat oligoasthenozoospermia (OAS). However, its mechanistic role in OAS needs better understood and necessitates more studies. This study was planned investigate GL's therapeutic effects the tripterygium wilfordii polyglycoside (GTW)-induced rat model. In total, 60 Sprague-Dawley (SD) rats at 8 weeks age were assigned six groups: blank (NC), model (GTW), GL low-dose (GL-L, 0.3 g/kg/day), medium-dose (GL-M, 0.6 high-dose (GL-H, 1.2 + PI3K inhibitor LY294002 (GL-H g/kg/day LY mg/kg/day) groups. The characterized after examine sperm concentration viability, serum hormone levels, testes histopathology, specific protein markers. treatment efficacy evaluated by mRNA expression among other parameters. Compared with GTW group, viability spermatozoa significantly increased intervention (

Язык: Английский

Процитировано

0