Novel Conservative Therapies in Migraine Management: The Impact of Fascia Exercises in a Randomized Controlled Trial

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 539 - 539

Опубликована: Янв. 16, 2025

Background/Objectives: Migraine is a complex neurological disorder often associated with autonomic nervous system (ANS) dysfunction. This study aimed to evaluate the effects of fascia exercises on migraine symptoms and explore their potential as novel conservative treatment approach. Methods: A prospective, randomized controlled trial was conducted 30 patients who were randomly assigned group (fascia exercises) or control (conventional physiotherapy). Both groups underwent six-week intervention consisting two sessions per week. Pain intensity, migraine-related disability, sleep quality, anxiety, depression, heart rate variability (HRV), patient satisfaction assessed before after using validated scales. Results: Significant improvements in pain attack frequency duration, anxiety levels observed both (p < 0.05). However, demonstrated more pronounced reduction depression scores compared While no significant changes HRV parameters detected either group, significantly higher Conclusions: Fascia represent promising complementary therapy for management, offering physical psychological symptoms. immediate not evident, modulate balance address pathophysiology warrants further exploration. These findings highlight value low-cost, non-invasive approach, emphasizing need research confirm long-term clinical benefits integration into protocols.

Язык: Английский

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A Meta-Analysis of the Influence on Inflammatory Factors in Type 2 Diabetes among Middle-Aged and Elderly Patients by Various Exercise Modalities

International Journal of Environmental Research and Public Health, Год журнала: 2023, Номер 20(3), С. 1783 - 1783

Опубликована: Янв. 18, 2023

The purpose of this study was to investigate the effects various exercise modalities on inflammatory factors in middle-aged and elderly patients with type 2 diabetes (MEPT2D), as lifestyle changes, such physical activity dietary modifications, are considered important prevention diabetes. For methodology, Pubmed, CNKI, EBSCO, Wanfang Data, Web Science were selected for search. methodological quality included studies assessed by Cochrane Risk Bias (ROB) tool, statistically analyzed using RevMan 5.4.1 analysis software, which 18 investigations involving 853 subjects. Meta-analysis findings indicated that aerobic training (AT), resistance (RT), combined (CT), high-intensity interval (HIIT) showed significant reductions CRP, TNF-α, IL-6, IL-10 levels MEPT2D. Among them, HIIT superior other reducing TNF-α levels, while CT AT, RT, decreasing IL-10, CRP Meanwhile, RT had limited However, no effect IL-6 In conclusion, long-term regular CT, all contributed reduction status (CRP, IL-10) MEPT2D, (for TNF-α) represent best approaches counteract response

Язык: Английский

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Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)

Aging Medicine, Год журнала: 2024, Номер 7(1), С. 5 - 51

Опубликована: Фев. 1, 2024

Abstract With the deepening of aging in China, prevalence diabetes older people has increased noticeably, and standardized management is critical for improving clinical outcomes people. In 2021, National Center Gerontology, Chinese Society Geriatrics, Diabetes Professional Committee Aging Well Association organized experts to write first guideline diagnosis treatment Guideline Management Mellitus Elderly China (2021 Edition) . The emphasizes that patients with are a highly heterogeneous group requiring comprehensive assessment stratified individualized strategies. proposes simple treatments de‐intensified strategies diabetes. This edition provides clinicians practical operable guidance, thus greatly contributing full‐cycle promoting extensive development basic research on related fields. past 3 years, evidence‐based medicine fields further advanced, new concepts, drugs, technologies have been developed. editorial committee promptly updated compiled (2024 More precise paths proposed, achieving continued standardization their outcomes.

Язык: Английский

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Physical exercise alone or combined with omega-3 modulates apical periodontitis induced in rats

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 13, 2025

Apical periodontitis (AP) results from bacterial contamination of the pulp tissue, with its progression highly influenced by host's immune response. This study aimed to evaluate impact moderate physical exercise, alone or combined omega-3 supplementation, on AP induced in rats. The analysis focused immuno-inflammatory profile, presence root canal and apical region, bone loss, collagen fiber production. Thirty Wistar rats were divided into three groups: Control, Physical Exercise (PE), + Omega-3 (PEO). supplementation was administered gavage for 60 days. swimming protocol included two stages: acclimatization aquatic environment training. 30th day, euthanized 60th day. Upper molars processed stained using Hematoxylin Eosin (H&E), Brown Brenn (BB), Picrosirius Red (PSR), immunohistochemistry IL-17, TNF-α, tartrate-resistant acid phosphatase (TRAP). Microtomographic also performed. Scores analyses evaluated Kruskal-Wallis, Tukey, Shapiro-Wilk, Mann-Whitney, One-Way ANOVA tests, a significance level 5% (p < 0.05). control group exhibited highest intensity inflammatory infiltrate PE reduced TNF-α immunostaining limited spread Combined further IL-17 increased percentage birefringent immature fibers revealed smaller areas alveolar loss animals subjected showed significantly higher number TRAP-positive cells In conclusion, enhanced defense mechanisms reducing inflammation through modulation controlling contamination. improved regulation modulating levels, stimulating production, thereby limiting decreasing osteoclastic activity.

Язык: Английский

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Impact of Concurrent Exercise Training on Cardiac Autonomic Modulation, Metabolic Profile, Body Composition, Cardiorespiratory Fitness, and Quality of Life in Type 2 Diabetes with Cardiac Autonomic Neuropathy: A Randomized Controlled Trial

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(13), С. 3910 - 3910

Опубликована: Июль 3, 2024

Background: Type 2 diabetes mellitus (T2DM) often leads to cardiac autonomic neuropathy (CAN), a severe complication affecting cardiovascular health. Exercise training is proven intervention for improving metabolic control and health in T2DM, but the effects of concurrent exercise (CET), combining aerobic resistance exercises, on CAN are not fully understood. Objective: This randomized controlled trial investigates impact structured CET program modulation, profile, body composition, cardiorespiratory fitness (CRF), quality life (QoL) individuals with T2DM CAN. Methods: A total 96 participants, aged 35-70 years, CAN, were into (n = 48) groups. The group engaged combined three times per week 13 weeks, while received standard care. Primary outcomes included heart rate variability (HRV) recovery (HRR). Secondary CRF, QoL, which assessed using standardized protocols validated questionnaires. was registered Clinical Trials Registry-India (CTRI/2021/09/036711). Results: Significant improvements noted compared controls. HRV metrics (SDNN, RMSSD, pNN50, TP, LF power, HF LF/HF ratio) HRR (HRR30s, HRR1, HRR2, HRR3) all showed significant enhancements (p < 0.01). also exhibited substantial reductions fasting blood glucose, postprandial HbA1c, waist circumference, hip percentage fat Improvements observed lipid profile markers CRF (VO2max) QoL scores improved significantly as ADDQoL-19 Conclusions: enhances These findings support integration management improve clinical QoL. Further research needed explore long-term benefits broader applicability diverse diabetic populations.

Язык: Английский

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The effects of aerobic exercise combined with resistance training on inflammatory factors and heart rate variability in middle‐aged and elderly women with type 2 diabetes mellitus

Annals of Noninvasive Electrocardiology, Год журнала: 2022, Номер 27(6)

Опубликована: Июль 27, 2022

Abstract Objective This study investigated the effects of aerobic exercise combined with resistance training on serum inflammatory factors and heart rate variability (HRV) in women type 2 diabetes mellitus (T2DM). Methods A total 30 patients diabetic cardiovascular autonomic neuropathy (DCAN) were randomly divided into a control group ( n = 15) an 15). The was treated routine hypoglycemic drugs, while drugs + (AE RT). levels fasting plasma glucose (FBG), two‐hour (2hPG), C‐reactive protein (CRP), interleukin‐6 (IL‐6) tumor necrosis factor alpha (TNF‐α) measured before after intervention. HRV evaluated by 24‐h ambulatory electrocardiogram. Results After intervention, FBG, 2hPG, factors, IL‐6 TNF‐α significantly lower than those p < .05) no significant differences CRP > .05). time domain frequency indexes two groups improved compared experiment .01) difference (lnlf) time‐domain indexes, i.e., SDNN RMSSD, as well index, (lnhf), higher group, whereas lnlf/lnhf Conclusions Compared drug therapy, combining helped to reduce level blood T2DM DCAN, nerve function.

Язык: Английский

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The Effect of Exercise on Cardiovascular Autonomic Nervous Function in Patients with Diabetes: A Systematic Review

Healthcare, Год журнала: 2023, Номер 11(19), С. 2668 - 2668

Опубликована: Окт. 1, 2023

Background: Diabetic neuropathy, including autonomic is a severe complication in patients with poorly controlled diabetes. Specifically, cardiovascular neuropathy (CAN) plays significant prognostic role morbidity and mortality. Exercise, an essential component of diabetes treatment, may have therapeutic effect on complicated by CAN. However, it remains unclear whether exercise has or protective Methods: The author conducted systematic search PubMed/MEDLINE, Embase, Cochrane Library, resulting the identification eight eligible randomized trials for this review. Results: aerobic combined resistance training (RT), high-intensity interval training, progressive RT, shown beneficial cardiac function (CAF) type 2 diabetes, as measured heart rate variability, recovery, baroreflex sensitivity. most studies had low quality. Moreover, there were no relevant examining CAF older patients, 1 Conclusions: Exercise potential to manage CAN balancing sympathetic parasympathetic nervous system functions; however, further are warranted future.

Язык: Английский

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Laboratory Assessment of the Effects of AGA@4life Multidisciplinary Intervention on the Inflammatory Profile, MMPs, and TIMPs in a Geriatric Population

Healthcare, Год журнала: 2024, Номер 12(5), С. 509 - 509

Опубликована: Фев. 21, 2024

In recent years, the world's aging population has increased, contributing to development of age-related pathologies, which have been aggravated by physical inactivity and excessive fat intake. This study aimed evaluate effect implementing a nutritional program (control group-CG) combined with exercise (intervention group-IG) on inflammatory profile, MMPs, TIMPs in group 34 elderly participants (IG,

Язык: Английский

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Exploring the causal link between circulating cytokines and sarcopenia traits: A Mendelian randomization analysis

Environmental Toxicology, Год журнала: 2024, Номер 39(6), С. 3434 - 3447

Опубликована: Март 7, 2024

Abstract Background Previous observational studies have linked circulating cytokines to sarcopenia, but their causal relationship remains unclear. This study employed Mendelian Randomization (MR) investigate the links between and sarcopenia‐related traits using genetic data. Methods A two‐sample bidirectional MR analysis was conducted data from individuals of European ancestry, utilizing genome‐wide association (GWAS) statistics. The selected instrumental single nucleotide polymorphisms (SNPs) significantly associated with applied multiple methods, including inverse variance weighted (IVW), Weighted Median, MR‐Egger, Mode, Simple MR‐PRESSO. analyzed were appendicular lean mass (ALM) grip strength. Heterogeneity, robustness, consistency results assessed Cochran's Q statistic, MR‐Egger regression, “leave‐one‐out” sensitivity analyses. Results IVM‐MR showed a casual genetically predicted levels interleukin‐16 both ALM strength (ALM: OR = 0.990, 95% CI: 0.980–1.000, p .049; strength: 0.971, 0.948–0.995, .020). Additionally, interferon‐gamma‐induced protein 10 (IP‐10), interleukin‐1‐beta (IL‐1β), hepatocyte growth factor (HGF) correlated vascular endothelial (VEGF), interleukin‐12 (IL‐12), interleukin‐5 (IL‐5) Comparable confirmed via Mode methods. Sensitivity no horizontal pleiotropy bias estimates. Conclusion suggest significant effect inflammatory on offering new avenues for therapeutic target development. However, study's focus ancestry cohort limits its generalizability other populations. Future research should aim include diverse ethnic groups validate broaden these findings, thereby enhancing our understanding sarcopenia's mechanisms in global context.

Язык: Английский

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Physiological mechanisms of neuromuscular impairment in diabetes‐related complications: Can physical exercise help prevent it?

The Journal of Physiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Diabetes mellitus is a chronic disorder that progressively induces complications, compromising daily independence. Among these, diabetic neuropathy particularly prevalent and contributes to substantial neuromuscular impairments in both types 1 2 diabetes. This condition leads structural damage affecting the central peripheral nervous systems, resulting significant decline sensorimotor functions. Alongside neuropathy, myopathy also muscle impairment reduced motor performance, intensifying decline. Diabetic typically implicates neurogenic atrophy, motoneuron loss clustering of fibres as result aberrant denervation-reinervation processes. These complications are associated with compromised junctions, where alterations occur pre-synaptic vesicles, mitochondrial content post-synaptic signalling. Neural intensified by hyperglycaemia oxidative stress, exacerbating vascular dysfunction reducing oxygen delivery. imply severe evidenced reductions maximal force power output, rate development endurance. Furthermore, diabetes-related compounded age-related degenerative changes long-term patients. Aerobic resistance training offer promising approaches for managing blood glucose levels function. exercise promotes biogenesis angiogenesis, supporting metabolic cardiovascular health. Resistance primarily enhances neural plasticity, strength hypertrophy, which crucial factors mitigating sarcopenia preserving functional topical review examines current evidence on physiological mechanisms underlying potential impact physical activity counteracting this

Язык: Английский

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