Recent frontiers in biofabrication for respiratory tissue engineering DOI Creative Commons
Amanda Zimmerling, Nuraina Anisa Dahlan,

Yan Zhou

и другие.

Bioprinting, Год журнала: 2024, Номер 40, С. e00342 - e00342

Опубликована: Апрель 21, 2024

Respiratory tissue engineering offers a robust framework for studying cell-cell and host-pathogen interactions in tissue-like environment platform lung regeneration disease mechanisms. However, the challenge of replicating dynamic three-dimensional (3D) microenvironments is huge obstacle with existing technology. Current animal models two-dimensional cell culture do not replicate vivo conditions seen human lungs, thus research utilizing these techniques often fails to help alleviate global burden respiratory diseases. has been drawing significant attention over past decade. Particularly emergence severe acute syndrome coronavirus 2 (SARS-CoV-2), many inspiring developments advances have reported. This review presents recent focusing on 3D bioprinting, organ-on-a-chip, organoid technologies. It also provides an overview attempts integrate biomechanical stimulus aim improving integrity constructs enhancing cellular propagation. addresses challenges inherent discusses future prospects this field, urging continuing innovation investment toward success increasing clinical relevance.

Язык: Английский

Recent frontiers in biofabrication for respiratory tissue engineering DOI Creative Commons
Amanda Zimmerling, Nuraina Anisa Dahlan,

Yan Zhou

и другие.

Bioprinting, Год журнала: 2024, Номер 40, С. e00342 - e00342

Опубликована: Апрель 21, 2024

Respiratory tissue engineering offers a robust framework for studying cell-cell and host-pathogen interactions in tissue-like environment platform lung regeneration disease mechanisms. However, the challenge of replicating dynamic three-dimensional (3D) microenvironments is huge obstacle with existing technology. Current animal models two-dimensional cell culture do not replicate vivo conditions seen human lungs, thus research utilizing these techniques often fails to help alleviate global burden respiratory diseases. has been drawing significant attention over past decade. Particularly emergence severe acute syndrome coronavirus 2 (SARS-CoV-2), many inspiring developments advances have reported. This review presents recent focusing on 3D bioprinting, organ-on-a-chip, organoid technologies. It also provides an overview attempts integrate biomechanical stimulus aim improving integrity constructs enhancing cellular propagation. addresses challenges inherent discusses future prospects this field, urging continuing innovation investment toward success increasing clinical relevance.

Язык: Английский

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