The relevance of daylight for humans

Biochemical Pharmacology, Год журнала: 2020, Номер 191, С. 114304 - 114304

Опубликована: Окт. 28, 2020

Daylight is ubiquitous and crucial for mammalian vision as well non-visual input to the brain via intrinsically photosensitive retinal ganglion cells (ipRGCs) that express photopigment melanopsin. The ipRGCs project circadian clock in suprachiasmatic nuclei thereby ensure entrainment 24-hour day-night cycle, changes daylength trigger appropriate seasonal behaviours. also perihabenular nucleus surrounding regions modulate mood, stress learning animals humans. Given light has strong direct effects on cognition, alertness, performance, sleep, can be considered a "drug" treat many clinical conditions. Light therapy already established winter other depressions sleep disorders. Beyond visual retina, daylight contributes prevent myopia young by its impact eye development, important Vitamin D synthesis bone health skin. sun most powerful source and, dependent dose, ultraviolet radiance toxic living organisms used disinfectant. Most research involves laboratory-based electric light, without dynamic spectral undergoes moment moment. There gap between importance of human beings amount being done this subject. taken granted an environmental factor, enjoyed or avoided, according More awareness architecture urban design beyond aesthetic values comfort may lead higher quality work environments. Although we do not yet have factual basis assumption natural overall "better" than debate mandates serious consideration sunlight just solar power but biologically necessary sustainable healthy living.

Язык: Английский

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Foundations of circadian medicine

PLoS Biology, Год журнала: 2022, Номер 20(3), С. e3001567 - e3001567

Опубликована: Март 24, 2022

The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption rhythms associated with many common pathologies. emerging field medicine aims exploit mechanisms clock–disease interaction for clinical diagnosis, treatment, prevention. In this Essay, we outline principle approaches medicine, highlight development in selected areas, point out open questions challenges. Circadian has unambiguous health benefits over standard care but rarely utilized. It biology become integrated part translational research.

Язык: Английский

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New Insights and Potential Therapeutic Interventions in Metabolic Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10672 - 10672

Опубликована: Июнь 26, 2023

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development new techniques insights has led to a deeper understanding mechanisms underlying these conditions opened up avenues for diagnosis treatment. In this review, we discussed rise diseases, especially Western countries, genetical, psychological, behavioral basis role nutrition physical activity single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, cell-based therapies diseases. Finally, practical applications derived from information are made.

Язык: Английский

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Meal timing and its role in obesity and associated diseases

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Март 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Язык: Английский

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Elderly as a High-risk Group during COVID-19 Pandemic: Effect of Circadian Misalignment, Sleep Dysregulation and Melatonin Administration

Sleep and Vigilance, Год журнала: 2020, Номер 4(2), С. 81 - 87

Опубликована: Сен. 26, 2020

Язык: Английский

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Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy

The Annual Review of Pharmacology and Toxicology, Год журнала: 2023, Номер 64(1), С. 89 - 114

Опубликована: Сен. 19, 2023

Today's challenge for precision medicine involves the integration of impact molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements tolerability and/or medications through proper administration timing have been confirmed over past decade immunotherapy chemotherapy against cancer, as well commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, neurological conditions. Experimental human studies recently revealed sexually dimorphic circadian responses. Dedicated randomized clinical trials should now aim to issue recommendations daily medical practice, integrating innovative technologies remote longitudinal monitoring metrics, statistical prediction clock function from single-timepoint biopsies, multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust function, who would benefit most chronotherapy, need be identified. Conversely, nonchronofit could emerging class chronobiotics targeting clock.

Язык: Английский

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Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

Acta Physiologica, Год журнала: 2023, Номер 238(2)

Опубликована: Март 31, 2023

Abstract Dysfunction of circadian and sleep rhythms is an early feature many neurodegenerative diseases. Alzheimer's disease (AD) a progressive disorder resulting in cognitive psychiatric disturbances. Although it largely unclear whether dysfunctions contribute to the etiology AD or are consequence disease, there evidence that these conditions involved complex self‐reinforcing bidirectional relationship. According recent studies, dysregulation clock already occurs during asymptomatic stage could promote neurodegeneration. Thus, restoration preclinical may represent opportunity for intervention slow course.

Язык: Английский

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Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO)

International Journal of Obesity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Язык: Английский

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Roles of clock genes in the pathogenesis of Parkinson's disease

Ageing Research Reviews, Год журнала: 2021, Номер 74, С. 101554 - 101554

Опубликована: Дек. 30, 2021

Язык: Английский

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When should I eat: A circadian view on food intake and metabolic regulation

Acta Physiologica, Год журнала: 2023, Номер 237(3)

Опубликована: Янв. 16, 2023

The circadian clock is a hierarchical timing system regulating most physiological and behavioral functions with period of approximately 24 h in humans other mammalian species. drives daily eating rhythms that, turn, reinforce the network itself to anticipate orchestrate metabolic responses food intake. Eating tightly interconnected recent evidence shows that meals crucial for control appetite regulation. Obesity results from combined long-term dysregulation intake (homeostatic hedonic circuits), energy expenditure, storage. Increasing supports loss synchrony significantly impairs homeostasis associated obesity. This review presents an overview mechanisms (homeostatic/hedonic) focuses on role response eating, thus providing fundamental research axis maintain healthy behavior.

Язык: Английский

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