Sleep spindles as a predictor of cognitive motor dissociation and recovery of consciousness after acute brain injury

Nature Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 8, 2023

Life expectancy is increasing throughout the world and coincides with a rise in non-communicable diseases (NCDs), especially for metabolic disease that includes diabetes mellitus (DM) neurodegenerative disorders. The debilitating effects of disorders influence entire body significantly affect nervous system impacting greater than one billion people disability peripheral as well cognitive loss, now seventh leading cause death worldwide. Metabolic disorders, such DM, neurologic remain significant challenge treatment care individuals since present therapies may limit symptoms but do not halt overall progression. These clinical challenges to address interplay between warrant innovative strategies can focus upon underlying mechanisms aging-related oxidative stress, cell senescence, death. Programmed pathways involve autophagy, apoptosis, ferroptosis, pyroptosis play critical role oversee processes include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, inflammatory activation. silent mating type information regulation 2 homolog 1

Язык: Английский

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Recent advances in understanding the kidney circadian clock mechanism

AJP Renal Physiology, Год журнала: 2024, Номер 326(3), С. F382 - F393

Опубликована: Янв. 4, 2024

Circadian rhythms are endogenous biological oscillations that regulate various physiological processes in organisms, including kidney function. The plays a vital role maintaining homeostasis by regulating water and electrolyte balance, blood pressure, excretion of metabolic waste products, all which display circadian rhythmicity. For this reason, studying the regulation is important, time day experimental variable must be considered. Over past decade, considerable progress has been made understanding molecular mechanisms underlying within kidney. In review, current knowledge regarding explored, focusing on clock machinery, control renal functions, impact disrupted health. addition, parameters should considered future directions outlined review.

Язык: Английский

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Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment

Current Opinion in Systems Biology, Год журнала: 2024, Номер 37, С. 100506 - 100506

Опубликована: Фев. 29, 2024

The growing numbers of cancer cases represent a medical and societal burden worldwide. More than half all patients are treated with chemotherapy. Yet, chemotherapeutic drugs kill not only cells, but also healthy tissue, causing massive adverse side effects. Recent research on circadian medicine suggests that side-effects can be reduced, treatment efficacy increased, by considering the biological clock patients. Integrating profiles molecular markers in personalized mathematical models simulate individual dynamics drug uptake, action cellular response to This requires advanced computational tools balance prediction quality overfitting. Personalized will eventually lead an optimal alignment timing inner patient, reducing effects, increasing enhancing patient well-being.

Язык: Английский

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Interaction between clock genes, melatonin and cardiovascular outcomes from ICU patients

Intensive Care Medicine Experimental, Год журнала: 2025, Номер 13(1)

Опубликована: Фев. 17, 2025

Abstract Background Circadian rhythms, driven by biological clocks, help organisms align their physiological functions with environmental changes, promoting homeostasis. The central clock in the suprachiasmatic nucleus coordinates peripheral clocks via neurohumoral feedback involving proteins like CLOCK, BMAL1, CRY 1/2, and PER 1–3. In ICU, these circadian processes often face disruptions from constant lighting, noise, irregular sleep–wake cycles, impairing sleep quality worsening stress responses. These can lead to adverse clinical effects, including higher cardiovascular complication rates. This study examines how ICU stays affect rhythm regulators association outcomes. Results Significant differences were identified melatonin levels expression of PER1, RORA, NR1D1 between ≤7 days >7 days. APACHE-II severity scale influenced PER2, CRY2, RORA. Nonlinear relationships observed melatonin, genes, heart rate, blood pressure (systolic diastolic). certain groups, molecular data showed correlations exceeding 90%. Conclusions findings highlight a robust disruption, as measured rhythms patients.

Язык: Английский

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Influence of envenomation timing on peripheral immune and oxidative responses in experimental scorpion envenomation

˜The œJournal of venomous animals and toxins including tropical diseases, Год журнала: 2025, Номер 31

Опубликована: Янв. 1, 2025

Abstract Background: Scorpion envenomation poses a significant health threat in endemic regions, eliciting complex immune responses affected individuals. Recent research suggests that the timing of - whether it occurs during day or night may influence host inflammatory response and subsequent organ damage. This study investigates impact on oxidative using an experimental scorpion model. Methods: Mice were divided into two groups, corresponding to their resting phase (day) activity (night), monitored for twenty-four hours post-envenomation. We analyzed systemic markers, hormonal changes within hypothalamic-pituitary-adrenal (HPA) axis, assessed liver toxicity. Results: Our findings reveal release myeloperoxidase enzyme, along with pro-inflammatory cytokines IL-6 IL-17, varied significantly based envenomation. Notably, occurring nighttime resulted elevated levels these mediators. also observed pronounced imbalance stress, characterized by higher presence prooxidant species daytime enhanced antioxidant activities nighttime. diurnal variation highlights dynamic nature processes. Importantly, our analysis points probable involvement corticosterone, final effector HPA modulating variations response. By influencing both intensity degree corticosterone appears play pivotal role overall pathophysiology Conclusion: provides valuable insights how influences organ-specific toxicity, offering potential implications treatment management cases.

Язык: Английский

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Effect of cyclic daytime versus continuous enteral nutrition on circadian rhythms in critical illness (CIRCLES): Study protocol for a randomized controlled trial

Contemporary Clinical Trials, Год журнала: 2025, Номер 154, С. 107927 - 107927

Опубликована: Апрель 27, 2025

Язык: Английский

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Association between ramelteon and 30‐day mortality in ICU patients with COVID‐19: A retrospective analysis of the MIMIC‐IV database

British Journal of Clinical Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Aims Melatonin may improve the prognosis of severe COVID‐19 patients. However, association between its analogue ramelteon and survival outcomes patients remains unclear. This retrospective study was conducted to investigate this knowledge gap. Methods The data admitted ICU were extracted from Medical Information Mart for Intensive Care IV 3.0 database. Patients categorized into group non‐ramelteon based on corresponding treatment. primary outcome 30‐day mortality. Subsequently, propensity score matching (PSM) inverse probability treatment weighting (IPTW) employed address confounding variables. Kaplan–Meier analysis, Cox proportional hazards regression subgroup analyses performed evaluate exposure outcomes. Results included 607 unexposed 459 exposed Thirty‐day mortality 10.2% in 30.1% group. 301 patient pairs PSM cohort showed that associated with significantly lower (12.3% vs . 19.6%, P = 0.012). IPTW also supported ( < 0.05). Finally, analysis invasive mechanically ventilated (IMV) have a greater benefit interaction 0.017). Conclusions suggests an COVID‐19, particularly among those receiving IMV. given design study, these findings should be interpreted as hypothesis‐generating rather than definitive.

Язык: Английский

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Innovative therapeutic strategies for cardiovascular disease.

PubMed, Год журнала: 2023, Номер 22, С. 690 - 715

Опубликована: Янв. 1, 2023

As a significant non-communicable disease, cardiovascular disease is the leading cause of death for both men and women, comprises almost twenty percent deaths in most racial ethnic groups, can affect greater than twenty-five million individuals worldwide over age twenty, impacts global economies with far-reaching financial challenges. Multiple factors onset that include high serum cholesterol levels, elevated blood pressure, tobacco consumption secondhand smoke exposure, poor nutrition, physical inactivity, obesity, concurrent diabetes mellitus. Yet, addressing any these cannot completely eliminate or progression disorders. Novel strategies are necessary to target underlying mechanisms. The silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), histone deacetylase, limit injury, assist stem cell development, oversee metabolic homeostasis through nicotinamide adenine dinucleotide (NAD+) pathways, foster trophic factor protection, control senescence modulation telomere function. Intimately tied SIRT1 pathways mammalian forkhead transcription (FoxOs) which modulate cardiac reduce oxidative stress, repair microcirculation disturbances, atherogenesis autophagy, apoptosis, ferroptosis. AMP activated protein kinase (AMPK) also critical among oversight cellular metabolism, insulin sensitivity, mitochondrial function, inflammation, susceptibility viral infections such as severe acute respiratory syndrome coronavirus impact disease. relationship intricate complex requires detailed insight successfully translate into clinical care

Язык: Английский

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Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity

Biomedicines, Год журнала: 2023, Номер 11(9), С. 2476 - 2476

Опубликована: Сен. 7, 2023

Astrocytes, the most abundant cells in brain, are integral to sleep regulation. In context of a healthy neural environment, these glial exert profound influence on sleep-wake cycle, modulating both rapid eye movement (REM) and non-REM phases. However, emerging literature underscores perturbations astrocytic function as potential etiological factors disorders, either protopathy or comorbidity. As known, disorders significantly increase risk neurodegenerative, cardiovascular, metabolic, psychiatric diseases. Meanwhile, commonly screened comorbidities various neurodegenerative diseases, epilepsy, others. Building existing research that examines role astrocytes this review aims elucidate mechanisms by which regulation contribute varied settings brain The emphasizes significance astrocyte-mediated their associated comorbidities, highlighting need for further research.

Язык: Английский

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