Mediating Role of Blood Metabolites in the Relationship Between Arrhythmia and Hyperthyroidism in East Asian Populations

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2025, Номер unknown, С. 103906 - 103906

Опубликована: Фев. 1, 2025

Язык: Английский

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Machine learning study on predicting depressive symptoms and genetic correlations in Parkinson’s disease

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 9, 2025

Depressive symptoms are prevalent in individuals with Parkinson's disease. Previous research has demonstrated a significant association between the triglyceride glucose (TyG) index and depression. Leveraging multicenter clinical data, present study evaluates predictive capacity of TyG for depressive PD patients, aiming to establish its potential role identifying at risk A comparative analysis multiple machine learning models was conducted predict depression ultimately selecting most effective model. Key variables, including diabetes status, sex, cholesterol levels, triglycerides, blood glucose, sleep disturbances, were incorporated into support vector (SVM)-based nomogram assess patients. Additionally, genome-wide (GWAS) utilizing external databases confirmed causal relationship Furthermore, this explores biological functions molecular mechanisms underlying shared transcriptomic proteins depression, providing insights pathophysiological links two conditions.

Язык: Английский

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Molecular Perspective of Dietary Influences on the Gut Microbiome alongside Neurological Health: Exploring the Gut-Brain Axis

ACS Chemical Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Gut-brain axis, an intricate, two-way communication network between gut microorganisms and the central nervous system, plays a critical role in controlling brain function thereby influencing mental health. Changes to this frequently due shifts microbiota, can greatly affect by hindering creation of essential metabolites. This review examines new nutritional trends, including fermented foods diets rich prebiotics, that demonstrate potential improve microbial diversity metabolic well-being. Although current studies emphasize possible advantages, most concentrate mainly on older populations, leaving research younger groups limited. The field psychiatry encounters difficulties methodologies intricacies nutrient balance, potentially prompt interventions. highlights necessity for prolonged evaluate effects eating habits, especially regarding Western dietary patterns. Promising fields include influence Mediterranean diet, symbiotic short-chain fatty acids (SCFAs), importance high-fiber foods, polyphenols, fruits vegetables enhancing health through gut-derived We promote interdisciplinary methods combine nutrition science, microbiology, neurology create tailored recommendations focused

Язык: Английский

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Neuroglial Advances: New Roles for Established Players

Journal of Neurochemistry, Год журнала: 2025, Номер 169(5)

Опубликована: Май 1, 2025

ABSTRACT Neuroglial cells perform numerous physiological functions and contribute to the pathogenesis of all diseases nervous system. neuroprotection defines resilience tissue exo‐ endogenous pathological challenges, while neuroglial defence determines progression outcome neurological disorders. IN this paper, we overview previously unknown but recently discovered roles various types in diverse processes. First, describe role ependymal glia regulation cerebrospinal fluid flow from spinal cord peripheral tissues through nerves. This newly pathway provides a highway for CNS–body volume transmission. Next, present mechanism by which astrocytes control migration differentiation oligodendrocyte precursor (OPCs). In pre‐ early postnatal CNS, OPCs migrate using vasculature (which is yet free limitans perivascularis) as pathfinder. Newly forming astrocytic perivascular endfeet signal (through semaphorin‐plexin cascade) that detach vessels start differentiate into myelinating oligodendrocytes. We continue astrocyte theme demonstrating neuroprotective APOE‐laden extracellular vesicles neuromyelitis optica. explore link between morphology stress‐induced depression. discuss critical ezrin, cytosolic linker defining terminal arborisation stress: overexpression ezrin prefrontal cortical makes mice resistant stress, whereas knockdown increases animals vulnerability stress. Subsequently, highlight pathophysiological oligodendroglial lineage schizophrenia describing novel hypertrophied post‐mortem patient's mouse model with overexpressing alternative splice variant DISC1‐Δ3. These DISC1‐Δ3‐OPCs demonstrated overactivated Wnt/β‐catenin signalling were sufficient trigger behaviours. Finally, deliberate on microglial connexin 43 hemichannels Alzheimer's disease new formula Cx43 hemichannel inhibitor increased blood–brain barrier penetration brain retention. image

Язык: Английский

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D-β-hydroxybutyrate upregulates tight junction protein zonula occludens-1 attenuating lipopolysaccharide-stimulated cerebral microvascular hyperpermeability

Tissue and Cell, Год журнала: 2025, Номер 96, С. 102998 - 102998

Опубликована: Май 29, 2025

Язык: Английский

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