American Journal of Obstetrics and Gynecology, Год журнала: 2022, Номер 228(2), С. 231.e1 - 231.e11
Опубликована: Авг. 17, 2022
Язык: Английский
The Lancet, Год журнала: 2021, Номер 398(10297), С. 341 - 354
Опубликована: Май 27, 2021
Язык: Английский
Процитировано
616
American Journal of Obstetrics and Gynecology, Год журнала: 2021, Номер 226(2), С. S907 - S927
Опубликована: Фев. 2, 2021
Язык: Английский
Процитировано
262
Placenta, Год журнала: 2020, Номер 101, С. 13 - 29
Опубликована: Авг. 23, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, was first identified after cluster of cases in Wuhan, China December 2019. Whether vertical transmission or placental pathology might occur following maternal infection during pregnancy remains unknown. This review aimed to summarise all studies that examined the placenta neonates with SARS-CoV-2, closely related highly pathogenic (SARS-CoV-1, Middle East (MERS-CoV)). Structured literature searches found 50 met inclusion criteria. Twenty reported histopathology findings third trimester placentas SARS-CoV-2 infection. Using Amsterdam Consensus criteria categorise results, evidence both fetal vascular malperfusion (35.3% cases; 95% Confidence Interval (CI) 27.7-43.0%) and (46% CI 38.0-54.0%) were reported, along inflammation (villitis 8.7% cases, intervillositis 5.3% chorioamnionitis 6% cases). pathologies observed consistent SARS-CoV-1 Of those tested, minority (2%) samples tested positive for (21%). Limited conclusions can be drawn about effect on as most lack control groups majority reports followed Collaboration maximise number will increase reliability generalisability findings. A better understanding association between inform maternity care pandemic.
Язык: Английский
Процитировано
215
Obstetrics and Gynecology Clinics of North America, Год журнала: 2019, Номер 47(1), С. 81 - 98
Опубликована: Дек. 18, 2019
Язык: Английский
Процитировано
161
Diagnostics, Год журнала: 2021, Номер 11(1), С. 94 - 94
Опубликована: Янв. 8, 2021
The current coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome 2 (SARS-CoV-2), has inflicted a serious health crisis globally. This virus is associated with spectrum of illness ranging from asymptomatic, mild to pneumonia, and distress syndrome. Accumulating evidence supports that COVID-19 not merely per se, but potentially affects other organ systems including placenta. SARS-CoV-2 gains access human cells via angiotensin-converting enzyme (ACE-2). abundance ACE-2 on placental cell surface, especially syncytiotrophoblasts, could contribute vertical transplacental transmission fetus following maternal infection. Intriguingly, despite placentas being tested positive for SARS-CoV-2, there are very few newborns manifest virus-induced diseases. protective effects barrier viral infection, limiting spread newborn infants, remain mystery. detrimental role in pregnancies largely debatable, although infection been implicated unfavorable pregnancy outcomes. In this review, we summarize pathological features manifested placenta due have previously reported, relate them possible manifestation. potential mechanistic pathways adverse outcomes also discussed.
Язык: Английский
Процитировано
159
Circulation, Год журнала: 2022, Номер 145(15), С. 1108 - 1119
Опубликована: Фев. 10, 2022
Neurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance outcomes. To explore whether antecedents for neurodevelopmental disabilities might begin utero, we analyzed fetal brain volume predicted subsequent outcome CHD.
Язык: Английский
Процитировано
99
Cells, Год журнала: 2020, Номер 9(8), С. 1777 - 1777
Опубликована: Июль 25, 2020
The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global public health crisis. Viral infections may predispose pregnant women to higher rate pregnancy complications, including preterm births, miscarriage and stillbirth. Despite reports neonatal COVID-19, definitive proof vertical transmission is still lacking. In this review, we summarize studies regarding potential evidence for transplacental severe acute respiratory syndrome 2 (SARS-CoV-2), characterize expression its receptors proteases, describe placental pathology analyze virus-host interactions at maternal-fetal interface. We focus on syncytium, barrier between mother fetus, in detail physical structural defense against viral infections. further discuss molecular mechanisms, whereby placenta serves as front pathogens by regulating interferon type III signaling, microRNA-triggered autophagy nuclear factor-κB pathway. Based these data, conclude that occur but rare, ascribed potent barrier, fine-regulated immune modulation strategies. Particularly, immunomodulatory mechanisms employed mitigate violent response, maybe soften cytokine storm tightly associated with severely ill COVID-19 patients, possibly minimizing cell tissue damages, potentially reducing SARS-CoV-2 transmission.
Язык: Английский
Процитировано
77
American Journal of Obstetrics and Gynecology, Год журнала: 2022, Номер 227(4), С. 615.e1 - 615.e25
Опубликована: Сен. 3, 2022
The major challenge for obstetrics is the prediction and prevention of great obstetrical syndromes. We propose that defining diseases by combination clinical presentation disease mechanisms as inferred placental pathology will aid in discovery biomarkers add specificity to those already known.
Язык: Английский
Процитировано
52
Anesthesia & Analgesia, Год журнала: 2021, Номер unknown
Опубликована: Апрель 8, 2021
Background: Early reports associating SARS-CoV-2 infection with adverse pregnancy outcomes were biased by including only women severe disease without controls. The Society for Obstetric Anesthesia and Perinatology (SOAP) COVID Registry was created to compare peripartum anesthetic utilization in delivering at institutions widespread testing. Methods: Deliveries from 14 U.S. medical centers, March 19-May 31, 2020, included. Peripartum defined as a positive polymerase chain reaction test within days of delivery. Consecutive infected patients randomly selected control sampled (1:2 ratio) controls during the same day test. Outcomes obstetric (e.g., delivery mode, hypertensive disorders pregnancy, < 37 weeks), an neonatal outcome composite measure (primary), neuraxial labor analgesia anesthesia). analyzed using generalized estimating equations account clustering centers. Sensitivity analyses compared symptomatic asymptomatic Results: 1454 included: 490 [176 (35.9%) symptomatic]; 964 slightly younger, more likely non-nulliparous, non-white, Hispanic than They have diabetes, obesity, or cardiac less autoimmune disease. After adjustment confounders, individuals experiencing exhibited increased risk weeks gestation controls, 73 (14.8%) vs. 98 (10.2%) [adjusted odds ratio (aOR): 1.47 95% CI (1.03-2.09)]. Effect estimates other not meaningfully different between SARS-CoV-2-patients versus In sensitivity analyses, exhibited: increases cesarean [aOR: 1.57 (1.09-2.27)]; postpartum length stay [aOR 1.89 (1.18-2.60)]; 2.08 (1.29-3.36)]. These found (asymptomatic symptomatic) receive 0.52 (0.35–0.75)] general anesthesia 3.69 (1.40–9.74)] due maternal respiratory failure. Conclusions: this large, multicenter cohort study infection, differences seem be mostly driven patients. Lower laboring requires further investigation.
Язык: Английский
Процитировано
49
Journal of Medical Virology, Год журнала: 2021, Номер 93(9), С. 5505 - 5514
Опубликована: Май 11, 2021
The impact of SARS-CoV-2 infection in pregnant women and their neonates is an area research interest nowadays. To date, there limited knowledge about prevalence, maternal perinatal outcomes at term middle- low-income countries. In the present retro-prospective study, medical records admitted for delivery were reviewed from largest Covid-19 dedicated Shri Maharaja Gulab Singh (SMGS) maternity hospital. screening was carried out all using RT-PCR. All born SARS-CoV-2-positive mothers isolated tested infection. Most (90.6%) asymptomatic time admission with a low prevalence (3.4%) SARS-CoV-2. A higher rate (86.1%) found among women. On basis RT-PCR result (negative vs. positive), statistically significant differences characteristics, such as mean gestational age (37.5 ± 2.2 36.6 3.3), comorbidity (2.9% 7.4%), like C-section (29.8% 58.3%), preterm (14.6% 28.3), neonatal birth weight (2840 450 2600 600), Apgar score (2.7% 6.48%), fetal distress (10.9% 22.2%) negative positive cases, respectively. No neonate to be
Язык: Английский
Процитировано
44