Pregnancy and COVID-19: past, present and future DOI Creative Commons
Young Keun Kim, Eui Hyeok Kim

Obstetrics & Gynecology Science, Год журнала: 2023, Номер 66(3), С. 149 - 160

Опубликована: Март 20, 2023

Current evidence suggests that severe acute respiratory syndrome coronavirus 2 infection is associated with an increased incidence of adverse maternal and perinatal outcomes. However, vertical transmission rare. The management pregnant women disease 2019 (COVID-19) similar to non-pregnant women, effective treatments, including antiviral therapy, dexamethasone, prophylactic anticoagulation should not be withheld during pregnancy.During the early COVID-19 pandemic period, was often delayed until polymerase chain reaction (PCR) results came out or due close contact, even among those without symptoms. Out concern for spread infection, cesarean sections were performed instead vaginal birth, since could have led increase in neonatal morbidities. Additionally, if PCR test positive, neonate quarantined, despite infectivity decreasing 10 days after symptom onset. It necessary ease strict measures control field obstetrics.The presence absence symptoms identified stratify risk, delivery can attempted asymptomatic low infectivity. With more being vaccinated safety data about vaccination rapidly accumulating no concerns been detected. Globally, vaccines are recommended pregnancy. In order prepare future pandemics, it apply lessons learned from this pandemic. Policymakers healthcare leaders must determine efficient strategies preserving safe care, ongoing global emergency.

Язык: Английский

Fetal and placental infection with SARS‐CoV‐2 in early pregnancy DOI Open Access
María Yolotzin Valdespino-Vázquez, Addy Cecilia Helguera‐Repetto, Moisés León‐Juárez

и другие.

Journal of Medical Virology, Год журнала: 2021, Номер 93(7), С. 4480 - 4487

Опубликована: Март 25, 2021

Abstract To date, mother‐to‐fetus transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the disease 2019 (COVID‐19) pandemic, remains controversial. Although placental COVID‐19 infection has been documented in some cases during second‐ and third‐trimesters, no reports are available first trimester pregnancy, SARS‐CoV‐2 protein found fetal tissues. We studied placenta organs from an early pregnancy miscarriage a maternal by immunohistochemical, reverse transcription quantitative real‐time polymerase chain reaction, immunofluorescence, electron microscopy methods. nucleocapsid protein, viral RNA, particles consistent with were tissues, accompanied RNA replication revealed double‐stranded (dsRNA) positive immunostain. Prominent damage associated hyperinflammatory process identified histological examination immunohistochemistry. The findings provided this study document that congenital is possible organs, such as lung kidney, targets coronavirus. multi‐organic inflammation produced should alert clinicians assessment management pregnant women consequences adverse perinatal outcomes.

Язык: Английский

Процитировано

72
Neonates and COVID-19: state of the art DOI Open Access
Lucy Ryan, Frans B. Plötz, Agnes van den Hoogen

и другие.

Pediatric Research, Год журнала: 2021, Номер 91(2), С. 432 - 439

Опубликована: Дек. 28, 2021

Язык: Английский

Процитировано

72
COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy DOI Creative Commons
Deepak Kumar, Sonam Verma, Indira U. Mysorekar

и другие.

Translational research, Год журнала: 2022, Номер 251, С. 84 - 95

Опубликована: Авг. 12, 2022

Язык: Английский

Процитировано

50
SARS-COV2 placentitis and pregnancy outcome: A multicentre experience during the Alpha and early Delta waves of coronavirus pandemic in England DOI Creative Commons

Sophie Stenton,

Jo McPartland,

Rajeev Shukla

и другие.

EClinicalMedicine, Год журнала: 2022, Номер 47, С. 101389 - 101389

Опубликована: Апрель 15, 2022

Язык: Английский

Процитировано

48
The impact of COVID-19 on pregnancy outcomes in a diverse cohort in England DOI Creative Commons
M. Wilkinson, Edward Johnstone, Louise Simcox

и другие.

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Янв. 18, 2022

There is conflicting evidence regarding the effect of coronavirus disease (COVID-19) in pregnancy. Risk factors for COVID-19 overlap with risk pregnancy complications. We aimed to assess effects pandemic and confirmed SARS-CoV-2 infection on outcomes. A retrospective interrupted time-series matched cohort analysis was performed. Singleton pregnancies completed between 1st January 2016 31st 2021 were included. Trends outcomes analysed over time. Modelled transmission data applied deliveries since 2020 assign a each pregnancy, incorporated into regression model birthweight. Confirmed cases controls delivered pre-pandemic period, maternal neonatal compared. 43,802 included, 8343 no increase stillbirth (p = 0.26) or death 0.64) during pandemic. association modelled attack rate (%) any trimester birthweight (first p 0.50, second 0.15, third 0.16). 214 COVID-positive women controls. Preterm birth more common symptomatic (14/62, 22.6%) compared asymptomatic (9/109, 8.3%, 0.008) (5/62, 8.1%, 0.025). Iatrogenic preterm (21/214, 9.8%) than (9/214, 4.2%, 0.02). All other examined similar groups. significant impact available. Symptomatic should be considered factor birth, possibly due an iatrogenic indications.

Язык: Английский

Процитировано

40
Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern DOI Open Access
Jan-Theile Suhren,

Andre Meinardus,

Kais Hussein

и другие.

Placenta, Год журнала: 2021, Номер 117, С. 72 - 77

Опубликована: Окт. 21, 2021

Язык: Английский

Процитировано

50
Case Report: Neonatal Multi-System Inflammatory Syndrome Associated With SARS-CoV-2 Exposure in Two Cases From Saudi Arabia DOI Creative Commons
Lana A. Shaiba,

Adnan Hadid,

Khalid A Altirkawi

и другие.

Frontiers in Pediatrics, Год журнала: 2021, Номер 9

Опубликована: Май 13, 2021

Background: Vertical transmission of SARS-CoV-2 is under investigation. A few reports suggest the possibility from mothers to their neonates. Most neonates have mild symptoms, but some develop multisystem involvement and shock. Case Presentation: We report two cases possible vertical The first case shows maternal infection with in second trimester followed by recurrent third right before delivery. infant demonstrated respiratory distress soon after delivery along myocardial dysfunction multi-organ system involvement. SARS-COV-2 at time preterm labor secondary placental abruption, that resulting neonate requiring non-invasive ventilation context persistently positive PCR neonate. Both were treated IVIG steroids. recovered fully discharged allowed go home. Conclusion: In neonates, COVID-19 usually presents as an asymptomatic or illness; may a more severe course. Our cases, however, demonstrate involvement, although rare, possible. This also supports current evidence might be underreported should considered when born suffering COVID-19. Clinical Trial Registration: [KSUMC], identifier [No#98763298].

Язык: Английский

Процитировано

44
Severe placental lesions due to maternal SARS-CoV-2 infection associated to intrauterine fetal death DOI
Charlotte Dubucs, Marion Groussolles,

Jessie Ousselin

и другие.

Human Pathology, Год журнала: 2022, Номер 121, С. 46 - 55

Опубликована: Янв. 5, 2022

Язык: Английский

Процитировано

39
Infants prenatally exposed to SARS-CoV-2 show the absence of fidgety movements and are at higher risk for neurological disorders: A comparative study DOI Creative Commons
Vania Aldrete–Cortez,

Liliana Bobadilla,

Silvia A. Tafoya

и другие.

PLoS ONE, Год журнала: 2022, Номер 17(5), С. e0267575 - e0267575

Опубликована: Май 4, 2022

Congenital viral infections are believed to damage the developing neonatal brain. However, whether neonates exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show manifestations of such remains unclear. For neurodevelopment evaluation, general movement assessments have been shown be effective in identifying early indicators neurological dysfunction, including absence fidgety movements. This study compared motor repertoire by assessment at three five months age who were or not prenatally SARS-CoV-2 determine infants risk disorders. Fifty-six infants, 28 group mothers without vaccination had no need for intensive care and likely infection close time pregnancy resolution nonexposed group, videotaped compare their detailed repertoires, which a optimality score-revised (MOS-R) was calculated using Prechtl's method chi-square Mann-Whitney U tests. In 3 (11%) showed movements with total MOS-R<14 points, other abnormal Between groups, atypical body symmetry (p = 0.009) MOS-R values significantly lower (Z -3.08, p 0.002), large size effect (Cohen's d 0.97). The consequences this new virus go beyond health pregnant mother, these some transitory because between 3-5 months; thus, babies increased serious disorder.

Язык: Английский

Процитировано

37
Analysis of placental pathology after COVID-19 by timing and severity of infection DOI Creative Commons

Chiara M. Corbetta-Rastelli,

Marie Altendahl,

Cynthia Gasper

и другие.

American Journal of Obstetrics & Gynecology MFM, Год журнала: 2023, Номер 5(7), С. 100981 - 100981

Опубликована: Апрель 23, 2023

COVID-19 during pregnancy can have serious effects on outcomes. The placenta acts as an infection barrier to the fetus and may mediate adverse Increased frequency of maternal vascular malperfusion has been detected in placentas patients with compared controls, but little is known about how timing severity affect placental pathology.

Язык: Английский

Процитировано

22