Dopamine: Functions, Signaling, and Association with Neurological Diseases

Cellular and Molecular Neurobiology, Год журнала: 2018, Номер 39(1), С. 31 - 59

Опубликована: Ноя. 16, 2018

Язык: Английский

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Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology

Neuropharmacology, Год журнала: 2019, Номер 172, С. 107704 - 107704

Опубликована: Июль 9, 2019

Язык: Английский

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Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control

Cells, Год журнала: 2021, Номер 10(4), С. 735 - 735

Опубликована: Март 26, 2021

Dopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement behavior, selected higher cognitive functions. Dysfunction dopaminergic transmission recognized as core alteration several devastating neurological psychiatric disorders, Parkinson’s disease (PD), schizophrenia, bipolar disorder, attention deficit hyperactivity disorder (ADHD) addiction. Here we will discuss the current insights on role DA control learning mechanisms its involvement synaptic dynamics through different pathways. In particular, consider neuromodulator two forms plasticity, known long-term potentiation (LTP) depression (LTD) cortical subcortical areas. Finally, delineate how effect dendritic spines places this molecule at interface between systems. Specifically, be focusing PD, vascular dementia, schizophrenia.

Язык: Английский

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Dopamine in Parkinson's disease

Clinica Chimica Acta, Год журнала: 2021, Номер 522, С. 114 - 126

Опубликована: Авг. 11, 2021

Язык: Английский

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Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease

Journal of Neuroimmune Pharmacology, Год журнала: 2019, Номер 15(1), С. 114 - 164

Опубликована: Май 11, 2019

Язык: Английский

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D ₄ dopamine receptor high-resolution structures enable the discovery of selective agonists

Science, Год журнала: 2017, Номер 358(6361), С. 381 - 386

Опубликована: Окт. 19, 2017

A strategy for drug discovery Dopamine receptors are G protein-coupled implicated in many neurological disorders. Different families of dopamine involved different signaling pathways, so specificity is a key goal therapeutics. Wang et al. present high-resolution crystal structures the DRD4 receptor bound to antipsychotic nemonapride. The high resolution facilitated ligand docking, and DRD4-selective agonist was identified by computational screening large library, experimental testing compounds with best docking scores, iterative cycles analogs those compounds. had affinity no measurable DRD2 or DRD3. Science , this issue p. 381

Язык: Английский

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Dopamine, Immunity, and Disease

Pharmacological Reviews, Год журнала: 2022, Номер 75(1), С. 62 - 158

Опубликована: Дек. 8, 2022

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions peripheral organs, such as blood pressure, renal activity, intestinal motility. Beyond these functions, growing body of evidence indicates that an important immunoregulatory factor. Most types immune cells express receptors other dopaminergic proteins, take up, produce, store, and/or release dopamine, suggesting immunomodulation for function. Targeting pathways could be promising avenue the treatment inflammation disease, but despite increasing research this area, data on specific effects disease remain inconsistent poorly understood. Therefore, review integrates current knowledge role cell function inflammatory signaling across systems. We discuss understanding regulation CNS tissues, highlighting diseases Parkinson’s several neuropsychiatric conditions, neurologic human immunodeficiency virus, bowel rheumatoid arthritis, others. Careful consideration given to influence experimental design results, we note number areas need further research. Overall, our immunology at cellular, tissue, level prompts development therapeutics strategies targeted toward ameliorating through immunity.

Significance Statement

Canonically, recognized involved cognition, reward. However, acts modulator periphery. This comprehensively assesses pathogenesis cellular tissue level. will provide broad access information fields, identify investigation, drive therapeutic strategies.

Язык: Английский

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Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

Scientific Reports, Год журнала: 2017, Номер 7(1)

Опубликована: Янв. 27, 2017

The loss of nigrostriatal dopamine neurons in Parkinson's disease induces a reduction the number dendritic spines on medium spiny (MSNs) striatum expressing D1 or D2 receptor. Consequences MSNs both receptors (D1/D2 MSNs) are currently unknown. We looked for changes induced by denervation density, regional distribution and morphological features D1/D2 MSNs, comparing 6-OHDA-lesioned double BAC transgenic mice (Drd1a-tdTomato/Drd2-EGFP) to sham-lesioned animals. uniformly distributed throughout dorsal (1.9% MSNs). In contrast, they heterogeneously more numerous ventral (14.6% shell 7.3% core). Compared endowed with smaller cell body less profusely arborized tree spines. spine density but also is significantly reduced mice. contrast extent arborization appears unaltered Our data indicate that mouse form distinct neuronal population affected differently deafferentation characterizes disease.

Язык: Английский

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Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity

Toxics, Год журнала: 2016, Номер 4(3), С. 19 - 19

Опубликована: Авг. 27, 2016

Neurotransmission is the basis of neuronal communication and critical for normal brain development, behavior, learning, memory. Exposure to drugs chemicals can alter neurotransmission, often through unknown pathways mechanisms. The zebrafish (Danio rerio) model system increasingly being used study chemical neurotoxicity. In this review, major neurotransmitter systems, including glutamate, GABA, dopamine, norepinephrine, serotonin, acetylcholine, histamine, glutamate are surveyed synthesis, transport, metabolism, action examined. Differences between human neurochemical highlighted. We also review techniques evaluating neurological function, measurement levels, assessment gene expression transcriptomic analysis, recording neurobehavior. Finally examples toxicity studies alterations in systems reviewed.

Язык: Английский

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Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease

Journal of Neurochemistry, Год журнала: 2016, Номер 139(S1), С. 156 - 178

Опубликована: Фев. 11, 2016

Abstract Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly vulnerable to degeneration compared other dopaminergic neurons. The age‐dependent, progressive loss of these is a pathological hallmark Parkinson's disease (PD), as resulting striatal dopamine causes its major movement‐related symptoms. SN DA release from their axonal terminals dorsal striatum, and also cell bodies dendrites midbrain in calcium‐ activity‐dependent manner. Their intrinsically generated metabolically challenging activity created modulated by orchestrated function different ion channels D2‐autoreceptors. Here, we review increasing evidence that mechanisms control patterns calcium homeostasis not only crucial for physiological range but modulate mitochondrial lysosomal activity, metabolic stress levels, vulnerability PD. Indeed, impaired homeostasis, dysfunction, represent central converging trigger factors idiopathic familial We summarize double‐edged roles channels, patterns, related feedback/feed‐forward signaling maintaining modulating function, contributing PD‐paradigms. focus on emerging maintained neuronal bandwidth, modulation PD‐triggers, well bidirectional functions voltage‐gated L‐type gated ATP‐sensitive potassium (K‐ATP) probable interplay health image propose possess several feedback feed‐forward protect adapt activity‐pattern calcium‐homeostasis PD‐trigger can narrow this bandwidth. view, findings documenting both, reduced elevated associated calcium‐levels degeneration. This article part special issue Parkinson .

Язык: Английский

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