Chronic diseases, inflammation, and spices: how are they linked?

Journal of Translational Medicine, Год журнала: 2018, Номер 16(1)

Опубликована: Янв. 25, 2018

Extensive research within the last several decades has revealed that major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. It is now well established these induce through induction of inflammation. However, inflammation could be either acute or chronic. Acute persists a short duration host defense against infections allergens, whereas long time leads to many including cancer, cardiovascular diseases, neurodegenerative respiratory etc. Numerous lines evidence suggest aforementioned induced cancer First, transcription NF-κB STAT3 regulate expression inflammatory gene products, have been found constitutively active in cancers; second, such as pancreatitis, prostatitis, hepatitis third, activation cell proliferation, survival, invasion, angiogenesis metastasis; fourth, resistance chemotherapy hypoxia acidic conditions activate factors. Therefore, targeting pathways may provide opportunities both prevention treatment other diseases. We will discuss this review potential various dietary agents spices its components suppression their roles therapy In fact, epidemiological studies do indicate incidence countries India where consumed daily much lower (94/100,000) than those not United States (318/100,000), suggesting role prevention.

Язык: Английский

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Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease

Molecules, Год журнала: 2017, Номер 22(3), С. 484 - 484

Опубликована: Март 19, 2017

Catechins are natural polyphenolic phytochemicals that exist in food and medicinal plants, such as tea, legume rubiaceae. An increasing number of studies have associated the intake catechins-rich foods with prevention treatment chronic diseases humans, inflammatory bowel disease (IBD). Some demonstrated catechins could significantly inhibit excessive oxidative stress through direct or indirect antioxidant effects promote activation antioxidative substances glutathione peroxidases (GPO) (GSH), reducing damages to colon. In addition, can also regulate infiltration proliferation immune related-cells, neutrophils, colonic epithelial cells, macrophages, T lymphocytes, helping reduce relations provide benefits IBD. Perhaps further deterioration intestinal lesions regulating cell gap junctions. Furthermore, exert their significant anti-inflammatory properties by deactivation inflammation-related stress-related signaling pathways, nuclear factor-kappa B (NF-κB), mitogen activated protein kinases (MAPKs), transcription factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer activator 1/3 (STAT1/3) pathways. Finally, stabilize structure gastrointestinal micro-ecological environment via promoting beneficial bacteria balance flora, so relieve may tight junctions (TJ) epithelium. This paper elaborates currently known possible molecular mechanisms favor

Язык: Английский

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Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

Molecules, Год журнала: 2020, Номер 25(6), С. 1397 - 1397

Опубликована: Март 19, 2020

Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune-modulating, metabolism regulating, anti-depressant, neuroprotective tissue protective effects. However, its poor solubility absorption in the free form gastrointestinal tract rapid biotransformation to inactive metabolites greatly limit utility as health-promoting agent dietary supplement. Recent advances micro- nano-formulations curcumin with enhanced resulting desirable blood levels active forms now make it possible address potential applications, pain management, protective. Using these highly bioavailable enable broad spectrum appropriate studies be conducted. This review discusses formulations designed enhance bioavailability, curcumin, relationships between particle size relative human pharmacokinetic involving formulated products, widely used but inappropriate practice hydrolyzing plasma samples for quantification current applications promising directions health maintenance applications.

Язык: Английский

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The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?

Advances in Nutrition, Год журнала: 2018, Номер 9(1), С. 41 - 50

Опубликована: Янв. 1, 2018

Язык: Английский

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The Mechanisms of Action of Curcumin in Alzheimer’s Disease

Journal of Alzheimer s Disease, Год журнала: 2017, Номер 58(4), С. 1003 - 1016

Опубликована: Май 19, 2017

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. As prevalence AD rises in 21st century, there an urgent need for development effective pharmacotherapies. Currently, drug treatments target symptoms and do not modify or halt progress. Thus, natural compounds have been investigated their ability to treat AD. This review examines efficacy curcumin, polyphenol derived from turmeric herb, We summarize vivo vitro research describing mechanisms action which curcumin modifies pathology: inhibits formation promotes disaggregation amyloid-β plaques, attenuates hyperphosphorylation tau enhances its clearance, binds copper, lowers cholesterol, microglial activity, acetylcholinesterase, mediates insulin signaling pathway, antioxidant. In conclusion, has potential be more efficacious than current treatments. However, usefulness as therapeutic agent may hindered by low bioavailability. If challenge bioavailability overcome, curcumin-based medications horizon.

Язык: Английский

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AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis

Gastroenterology, Год журнала: 2018, Номер 156(3), С. 748 - 764

Опубликована: Дек. 18, 2018

Язык: Английский

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Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

Neural Plasticity, Год журнала: 2017, Номер 2017, С. 1 - 22

Опубликована: Янв. 1, 2017

The number of the elderly across globe will approximate 2.1 billion by 2050. Juxtaposed against this burgeoning segment population is evidence that nonpathological aging associated with an increased risk for cognitive decline in a variety domains, changes can cause mild disability even before onset dementia. Given pharmacological treatments mitigate dementia are still outstanding, alternative therapeutic options being investigated increasingly. results from translational studies have shown modifiable lifestyle factors—including physical activity, engagement, and diet—are key strategy maintaining brain health during aging. Indeed, multiplicity has demonstrated relationships between factors, structure function, function adults. For example, activity diet modulate common neuroplasticity substrates (neurotrophic signaling, neurogenesis, inflammation, stress response, antioxidant defense) whereas engagement enhances reserve. aims review to evaluate relationship neuroplasticity, optimal aging; identify putative mechanisms contribute positive highlight future directions scientists clinicians. Undoubtedly, translation cutting-edge knowledge derived field neuroscience advance our understanding enhance clinical treatment interventions as we endeavor promote

Язык: Английский

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A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Март 25, 2022

Linn. (

Язык: Английский

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Curcumin: an inflammasome silencer

Pharmacological Research, Год журнала: 2020, Номер 159, С. 104921 - 104921

Опубликована: Май 25, 2020

Язык: Английский

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Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea

Molecules, Год журнала: 2018, Номер 23(11), С. 2778 - 2778

Опубликована: Окт. 26, 2018

The immune system is an efficient integrated network of cellular elements and chemicals developed to preserve the integrity organism against external insults its correct functioning balance are essential avoid occurrence a great variety disorders. To date, evidence from literature highlights increase in immunological diseases attention has been focused on development molecules able modulate response. There enormous global demand for new effective therapies researchers investigating fields. One promising strategy use herbal medicines as integrative, complementary preventive therapy. active components medical plants have always important source clinical therapeutics study their molecular pharmacology challenge since they offer chemical diversity with often multi-pharmacological activity. In this review, we mainly analysed immunomodulatory/antinflammatory activity Echinacea spp. Curcuma longa, focusing some issues phytochemical research possible strategies obtain novel agents supplement present therapies.

Язык: Английский

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