Life Sciences, Год журнала: 2020, Номер 267, С. 118814 - 118814
Опубликована: Дек. 16, 2020
Язык: Английский
Molecules, Год журнала: 2019, Номер 24(16), С. 2930 - 2930
Опубликована: Авг. 13, 2019
Turmeric is a curry spice that originated from India, which has attracted great interest in recent decades because it contains bioactive curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin). Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione), lipophilic polyphenol may work as an anticancer, antibiotic, anti-inflammatory, anti-aging agent suggested by several vitro, vivo studies clinical trials. However, poor aqueous solubility, bioavailability, pharmacokinetic profiles limit curcumin’s therapeutic usage. To address these issues, curcumin formulations have been developed. suboptimal sample preparation analysis methodologies often hamper the accurate evaluation of bioactivities their efficacy. This review summarizes research on biological, pharmaceutical, analytical aspects curcumin. Various formulation techniques corresponding trials outcomes are discussed. A detailed comparison different (ultrasonic, pressurized liquid extraction, microwave, reflux) (FT-IR, FT-NIR, FT-Raman, UV, NMR, HPTLC, HPLC, LC-MS/MS) used for extraction quantification matrices, presented. Application optimal preparation, chromatographic separation, detection will significantly improve assessment biological activities curcuminoids.
Язык: Английский
Процитировано
663
Molecules, Год журнала: 2018, Номер 23(11), С. 2778 - 2778
Опубликована: Окт. 26, 2018
The immune system is an efficient integrated network of cellular elements and chemicals developed to preserve the integrity organism against external insults its correct functioning balance are essential avoid occurrence a great variety disorders. To date, evidence from literature highlights increase in immunological diseases attention has been focused on development molecules able modulate response. There enormous global demand for new effective therapies researchers investigating fields. One promising strategy use herbal medicines as integrative, complementary preventive therapy. active components medical plants have always important source clinical therapeutics study their molecular pharmacology challenge since they offer chemical diversity with often multi-pharmacological activity. In this review, we mainly analysed immunomodulatory/antinflammatory activity Echinacea spp. Curcuma longa, focusing some issues phytochemical research possible strategies obtain novel agents supplement present therapies.
Язык: Английский
Процитировано
236
International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(6), С. 1812 - 1812
Опубликована: Июнь 20, 2018
Inflammation is the principal response invoked by body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it well known that unchecked or chronic becomes deleterious, leading progressive damage. Studies over past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since was recognized play central role several diseases. In this review, we discuss beneficial effects resveratrol, most widely investigated polyphenol, cancer neurodegenerative, respiratory, metabolic, cardiovascular We highlight how despite its unfavorable pharmacokinetics, can modulate inflammatory pathways underlying those diseases, identify future opportunities for evaluation clinical feasibility.
Язык: Английский
Процитировано
235
Molecules, Год журнала: 2019, Номер 24(14), С. 2527 - 2527
Опубликована: Июль 10, 2019
Many chemotherapeutic drugs have been used for the treatment of cancer, instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, effectiveness chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, undesirable side effects. The combination therapies with natural compounds likely increase as well reduce adverse outcomes. Curcumin, a polyphenolic isolated from
Язык: Английский
Процитировано
210
International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(17), С. 4101 - 4101
Опубликована: Авг. 22, 2019
Natural compounds, in recent years, have attracted significant attention for their use the prevention and treatment of diverse chronic diseases as they are devoid major toxicities. Boswellic acid (BA), a series pentacyclic triterpene molecules, is isolated from gum resin Boswellia serrata carteri. It proved to be one such agent that has exhibited efficacy against various like arthritis, diabetes, asthma, cancer, inflammatory bowel disease, Parkinson’s Alzheimer’s, etc. The molecular targets attributed its wide range biological activities include transcription factors, kinases, enzymes, receptors, growth present review an attempt demonstrate pharmacological uses BA, along with underlying mechanism action different ailments. Further, this also discusses roadblocks associated pharmacokinetics bioavailability promising compound strategies overcome those limitations developing it effective drug clinical management diseases.
Язык: Английский
Процитировано
185
Pharmacological Research, Год журнала: 2020, Номер 153, С. 104635 - 104635
Опубликована: Янв. 8, 2020
Язык: Английский
Процитировано
184
Nature Reviews Nephrology, Год журнала: 2020, Номер 17(3), С. 153 - 171
Опубликована: Сен. 22, 2020
Язык: Английский
Процитировано
181
International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(9), С. 3285 - 3285
Опубликована: Май 6, 2020
Oral cancer (OC) is a devastating disease that takes the lives of lots people globally every year. The current spectrum treatment modalities does not meet needs patients. heterogeneity demands personalized medicine or targeted therapies. Therefore, there an urgent need to identify potential targets for OC. Abundant evidence has suggested components protein kinase B (AKT)/ mammalian target rapamycin (mTOR) pathway are intrinsic factors carcinogenesis. AKT central proliferation and survival normal cells, its downstream protein, mTOR, also plays indispensable role in cellular processes. wide involvement AKT/mTOR been noted oral squamous cell carcinoma (OSCC). This axis significantly regulates various hallmarks cancer, like proliferation, survival, angiogenesis, invasion, metastasis, autophagy, epithelial-to-mesenchymal transition (EMT). Activated signaling associated with circadian signaling, chemoresistance radio-resistance OC cells. Several miRNAs, circRNAs lncRNAs modulate this pathway. association process tumorigenesis culminated identification specific inhibitors prevention In review, we discussed significance as therapeutic management article provided update on several emerged promising candidates interventions against OC/head neck (HNC) clinical studies.
Язык: Английский
Процитировано
175
Pharmacological Research, Год журнала: 2019, Номер 144, С. 192 - 209
Опубликована: Апрель 17, 2019
Язык: Английский
Процитировано
165
Pharmaceutics, Год журнала: 2021, Номер 13(2), С. 291 - 291
Опубликована: Фев. 23, 2021
Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and widely distributed in citrus fruits some other such as bergamot, tomatoes, cocoa, cherries. NRG presents several interesting pharmacological properties, anti-cancer, anti-oxidant, anti-inflammatory activities. However, therapeutic potential hampered due its hydrophobic nature, which leads poor bioavailability. Here, we review wide range nanocarriers that have been used delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured carriers (NLCs), nanosuspensions, nanoemulsions. These nanomedicine formulations applied treatment diseases, using vitro, ex vivo, vivo models different routes administration. From this review, it can be concluded option various diseases cancer, neurological disorders, liver ocular inflammatory skin diabetes when formulated appropriate nanocarriers.
Язык: Английский
Процитировано
144