Inflammation, not Cholesterol, Is a Cause of Chronic Disease

Nutrients, Год журнала: 2018, Номер 10(5), С. 604 - 604

Опубликована: Май 12, 2018

Since the Seven Countries Study, dietary cholesterol and levels of serum in relation to development chronic diseases have been somewhat demonised. However, principles Mediterranean diet relevant data linked examples people living five blue zones demonstrate that key longevity prevention disease is not reduction or but control systemic inflammation. In this review, we present all supports view it inflammation induced by several factors, such as platelet-activating factor (PAF), leads onset cardiovascular (CVD) rather than cholesterol. The reducing incidence CVD activities PAF other inflammatory mediators via diet, exercise, healthy lifestyle choices. studies supporting these views are discussed review.

Язык: Английский

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Exercise‐induced muscle damage: What is it, what causes it and what are the nutritional solutions?

European Journal of Sport Science, Год журнала: 2018, Номер 19(1), С. 71 - 85

Опубликована: Авг. 15, 2018

Abstract Exercise‐induced muscle damage (EIMD) is characterized by symptoms that present both immediately and for up to 14 days after the initial exercise bout. The main consequence of EIMD athlete loss skeletal function soreness. As such, numerous nutrients functional foods have been examined their potential ameliorate effects accelerate recovery, which purpose many nutritional strategies athlete. However, trade‐off between recovery adaptation rarely considered. For example, interventions described in this review target oxidative stress inflammation, thought contribute but are also crucial process. This calls into question whether long term administration supplements used indeed best practice. rapidly growing area sports nutrition will benefit from careful consideration hormetic effect use aids damage. provides a concise overview what is, its causes consequences critically evaluates EIMD. We pragmatic practical summary can be adopted practitioners direct future research, with pushing field better consider fine balance modulating balance.

Язык: Английский

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Polyphenols, food and pharma. Current knowledge and directions for future research

Biochemical Pharmacology, Год журнала: 2018, Номер 156, С. 186 - 195

Опубликована: Авг. 4, 2018

Язык: Английский

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Is There Such a Thing as “Anti-Nutrients”? A Narrative Review of Perceived Problematic Plant Compounds

Nutrients, Год журнала: 2020, Номер 12(10), С. 2929 - 2929

Опубликована: Сен. 24, 2020

Plant-based diets are associated with reduced risk of lifestyle-induced chronic diseases. The thousands phytochemicals they contain implicated in cellular-based mechanisms to promote antioxidant defense and reduce inflammation. While recommendations encourage the intake fruits vegetables, most people fall short their target daily intake. Despite need increase plant-food consumption, there have been some concerns raised about whether beneficial because various 'anti-nutrient' compounds contain. Some these anti-nutrients that called into question included lectins, oxalates, goitrogens, phytoestrogens, phytates, tannins. As a result, may be select individuals specific health conditions who elect decrease plant food despite potential benefits. purpose this narrative review is examine science 'anti-nutrients' weigh evidence pose an actual threat.

Язык: Английский

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Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

International Journal of Environmental Research and Public Health, Год журнала: 2020, Номер 17(7), С. 2326 - 2326

Опубликована: Март 30, 2020

Heart and blood vessels disorders comprise one of the main causes death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around world traditional way. Dietary, bioactive compounds, well healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical clinical studies reported that consumption plant-food derivatives including polyphenolic peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on This review aims summarize risk factors, pre-clinical trials related cardioprotective properties plant-food-derived compounds. Molecular mechanisms by exert their also highlighted.

Язык: Английский

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Bioactivity of Olive Oil Phenols in Neuroprotection

International Journal of Molecular Sciences, Год журнала: 2017, Номер 18(11), С. 2230 - 2230

Опубликована: Окт. 25, 2017

Neurological disorders such as stroke, Alzheimer’s and Parkinson’s diseases are associated with high morbidity mortality, few or no effective options available for their treatment. These share common pathological characteristics like the induction of oxidative stress, abnormal protein aggregation, perturbed Ca2+ homeostasis, excitotoxicity, inflammation apoptosis. A large body evidence supports beneficial effects Mediterranean diet in preventing neurodegeneration. As is characterized by a consumption extra-virgin olive oil it has been hypothesized that oil, particular its phenols, could be responsible effect diet. This review provides an updated vision properties phenols preventing/counteracting both acute chronic neurodegenerative diseases.

Язык: Английский

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Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

Molecules, Год журнала: 2023, Номер 28(17), С. 6403 - 6403

Опубликована: Сен. 1, 2023

Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary exhibit chemopreventive therapeutic effects against numerous diseases. Polyphenols are found in fruits, grains. compounds several health benefits such as immune modulators, vasodilators, antioxidants. This review focuses on recent studies using polyphenols to treat cardiovascular disorders, atherosclerosis, vascular endothelium deficits. We focus exploring the safety of highly effective ensure their maximum impact cardiac abnormalities discuss epidemiological evidence intervention trials related these properties. Kaempferol, quercetin, resveratrol prevent oxidative stress by regulating proteins that induce oxidation heart tissues. In addition, modulate tone vessels releasing nitric oxide (NO) reducing low-density lipoprotein (LDL) atherosclerosis. cardiomyocytes, suppress expression inflammatory markers inhibit production inflammation exert an anti-inflammatory response. Consequently, diseases strokes, hypertension, failure, ischemic disease could prevented polyphenols.

Язык: Английский

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Oxidative Stress, Antioxidants and Hypertension

Antioxidants, Год журнала: 2023, Номер 12(2), С. 281 - 281

Опубликована: Янв. 27, 2023

As a major cause of morbidity and mortality globally, hypertension remains serious threat to global public health. Despite the availability many antihypertensive medications, several hypertensive individuals are resistant standard treatments, unable control their blood pressure. Regulation renin-angiotensin-aldosterone system (RAAS) controlling pressure, activation immune triggering inflammation production reactive oxygen species, leading oxidative stress redox-sensitive signaling, have been implicated in pathogenesis hypertension. Thus, besides which lower arterial antioxidant medications were tested improve treatment. We review discuss role pathophysiology potential use antioxidants management its associated organ damage.

Язык: Английский

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The Influence of Dietary Interventions on Arterial Stiffness in Overweight and Obese Subjects

Nutrients, Год журнала: 2023, Номер 15(6), С. 1440 - 1440

Опубликована: Март 16, 2023

Arterial stiffness is often increased in overweight/obese subjects before the development of hypertension. It also one earliest indicators cardiovascular disease risk and can be considered a good predictor subclinical dysfunction. significant prognostic factor influencing risk, which dietary habits modify. Obese patients should use caloric-restricted diet because it augments aortic distensibility, diminishes pulse wave velocity (PWV), increases activity endothelial nitric oxide synthases. High intake saturated fatty acids (SFA), trans fats, cholesterol, typical for Western diet, impairs function raises brachial-ankle PWV. The replacement SFA with monounsaturated (MUFA) or polyunsaturated (PUFA) derived from seafood plants arterial stiffness. dairy product (excluding butter) decreases PWV general population. high-sucrose causes toxic hyperglycemia Complex carbohydrates low glycemic index (including isomaltose) recommended to keep vascular health. high sodium (>10 g/day), particularly associated potassium consumption, has deleterious effect on (↑ baPWV). Since vegetables fruits are sources vitamins phytochemicals, they Thus, recommendation prevent similar Mediterranean rich products, plant oils, fish, minimal red meat five servings daily.

Язык: Английский

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Principles of pharmacological research of nutraceuticals

British Journal of Pharmacology, Год журнала: 2017, Номер 174(11), С. 1177 - 1194

Опубликована: Май 12, 2017

Linked Articles This article is part of a themed section on Principles Pharmacological Research Nutraceuticals. To view the other articles in this visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.11/issuetoc

Язык: Английский

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