Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma

Journal of Molecular Neuroscience, Год журнала: 2023, Номер 73(11-12), С. 875 - 883

Опубликована: Окт. 16, 2023

Язык: Английский

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Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Biomolecules, Год журнала: 2021, Номер 11(12), С. 1866 - 1866

Опубликована: Дек. 11, 2021

Nitric oxide (NO), the neuromodulator/neurotransmitter formed from l-arginine by neuronal, endothelial and inducible NO synthases, is involved in numerous functions across body, control of arterial blood pressure to penile erection, at central level energy homeostasis regulation memory, learning sexual behavior. The aim this work review earlier studies showing that plays a role erectile function behavior hypothalamus its paraventricular nucleus medial preoptic area, integrate these findings with those recent on matter. This revisitation shows influences males females acting not only area but also extrahypothalamic brain areas, often different mechanisms. Most importantly, since areas are strictly interconnected send receive neural projections spinal cord, which communication between genital apparatus takes place, reveals participates concert neurotransmitters/neuropeptides circuit controlling both consummatory (penile copulation, lordosis) appetitive components (sexual motivation, arousal, reward)

Язык: Английский

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Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier

Handbook of clinical neurology, Год журнала: 2021, Номер unknown, С. 253 - 273

Опубликована: Янв. 1, 2021

Язык: Английский

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Nitric oxide involvement in the disability and active disease of multiple sclerosis: Systematic review and meta-analysis

Nitric Oxide, Год журнала: 2024, Номер 145, С. 8 - 20

Опубликована: Фев. 6, 2024

Язык: Английский

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Advances in the Electrophysiological Recordings of Long-Term Potentiation

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7134 - 7134

Опубликована: Апрель 12, 2023

Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, neurological diseases is critical. However, recently, despite the rapid advancement neuroscience, we are still constrained by experimental design, detection tools for exploring mechanisms pathways involved LTP induction, ability of action signals. This review will reiterate LTP-related electrophysiological recordings mammalian brain nearly 50 years explain how excitatory inhibitory neural results have been detected described field- single-cell potentials, respectively. Furthermore, focus on describing classic model inhibition discuss neuron activity when neurons activated to induce LTP. Finally, propose recording under same conditions combining various technologies novel design suggestions future research. We discussed different types synaptic plasticity, potential astrocytes also deserves be explored future.

Язык: Английский

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Effects of extended-release 7-nitroindazole gel formulation treatment on the behavior of Shank3 mouse model of autism

Nitric Oxide, Год журнала: 2023, Номер 140-141, С. 41 - 49

Опубликована: Сен. 14, 2023

Язык: Английский

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Changes of Signaling Pathways in Hypothalamic Neurons with Aging

Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(10), С. 8289 - 8308

Опубликована: Окт. 12, 2023

The hypothalamus is an important regulator of autonomic and endocrine functions also involved in aging regulation. process the accompanied by disturbed intracellular signaling including insulin/insulin-like growth factor-1 (IGF-1)/growth hormone (GH), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT)/the mammalian target rapamycin (mTOR), mitogen activated protein (MAPK), janus (JAK)/signal transducer activator transcription (STAT), AMP-activated (AMPK), nuclear factor kappa-light-chain-enhancer cells (NF-ĸB), nitric oxide (NO). In current review, I have summarized understanding changes above-mentioned pathways with a focus on hypothalamic alterations.

Язык: Английский

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Changes of nNOS expression in the tuberal hypothalamic nuclei during ageing

Nitric Oxide, Год журнала: 2020, Номер 100-101, С. 1 - 6

Опубликована: Апрель 10, 2020

Язык: Английский

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Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology

Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 205 - 236

Опубликована: Янв. 1, 2021

Язык: Английский

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Modulation of Heart Rate Variability and Brain Excitability through Acute Whole-Body Vibration: The Role of Frequency

Journal of Human Kinetics, Год журнала: 2024, Номер 92, С. 111 - 120

Опубликована: Апрель 25, 2024

This cross-over study aimed to explore effects of acute whole-body vibration (WBV) at frequencies 5–35 Hz on heart rate variability and brain excitability. Thirteen healthy physically active college students randomly completed eight interventions under the following conditions: static upright standing without (CON), squat exercise (knee flexion 150°) platform (SSE), combined with WBV frequency 5, 9, 13, 20, 25, 35 Hz. Five bouts × 30 s a 30-s rest interval were performed for all interventions. The brain’s direct current potentials (DCPs), domain variables (FDV) including normalized low power (nLF), high (nHF) ratio LF HF (LF/HF), along mean (MHR) collected calculated before after intervention. Results suggested that 5 had substantial effect decreasing DCPs [−2.13 μV, t(84) = −3.82, p < 0.05, g −1.03, large] nLF [−13%, −2.31, 0.04, −0.62, medium]. By contrast, 20–35 intervention considerably improved [7.58 4.31, 1.16, large], [17%, 2.92, 0.79, LF/HF [0.51, 2.86, 0.77, large]. A strong (r 0.7, 0.01) correlation between was found In summary, principally activated sympathetic nervous system increased excitability, while 5-Hz parasympathetic reduced spectrum might be manipulated according target

Язык: Английский

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