Biological Effects of CYP11A1-Derived Vitamin D and Lumisterol Metabolites in the Skin

Journal of Investigative Dermatology, Год журнала: 2024, Номер 144(10), С. 2145 - 2161

Опубликована: Июль 12, 2024

Язык: Английский

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Malignant Melanoma: An Overview, New Perspectives, and Vitamin D Signaling

Cancers, Год журнала: 2024, Номер 16(12), С. 2262 - 2262

Опубликована: Июнь 18, 2024

Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and high mortality rate. This review discusses etiologic risk factors for melanoma, diagnostic prognostic tools, including recent advances in molecular biology, omics, bioinformatics, provides an overview its therapy. Since the incidence melanoma rising remains unacceptably high, we discuss inherent properties, melanogenesis, that make this disease resilient treatment propose use AI solve above complex multidimensional problems. We provide on vitamin D anticancerogenic report field can solutions prevention and/or therapy melanoma. Experimental papers clinicopathological studies role status signaling pathways initiated active metabolites prognosis are reviewed. conclude signaling, defined specific nuclear receptors selective activation hydroxyderivatives, benefit new or existing therapeutic approaches. target with computational biology tools solution problem.

Язык: Английский

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Melatonin attenuates BDE-209-caused spatial memory deficits in juvenile rats through NMDAR-CaMKⅡγ-mediated synapse-to-nucleus signaling

Food and Chemical Toxicology, Год журнала: 2025, Номер 196, С. 115243 - 115243

Опубликована: Янв. 8, 2025

Язык: Английский

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Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease—A Comprehensive Review

Nutrients, Год журнала: 2024, Номер 16(11), С. 1762 - 1762

Опубликована: Июнь 4, 2024

Autoimmune thyroid diseases (AITD) are among the most frequent autoimmune disorders, with a multifactorial etiology in which both genetic and environmental determinants probably involved. Celiac disease (CeD) also represents public concern, given its increasing prevalence due to recent improvement of screening programs, leading detection silent subtypes. The two conditions may be closely associated common risk factors, including setting, changes composition diversity gut microbiota, deficiency nutrients like vitamin D. This comprehensive review discussed current evidence on pivotal role D modulating microbiota dysbiosis immune system dysfunction, shedding light possible relevance an adequate intake this nutrient primary prevention AITD CeD. While future technology-based strategies for proper supplementation could attractive context personalized medicine, several issues remain defined, standardized assays determination, timely recommendations functioning, longitudinal studies randomized controlled trials definitely establish causal relationship between serum levels onset

Язык: Английский

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Advanced and Metastatic Non-Melanoma Skin Cancer: Epidemiology, Risk Factors, Clinical Features, and Treatment Options

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1448 - 1448

Опубликована: Июнь 28, 2024

Non-melanoma skin cancers (NMSC) form the majority of cancers, with basal cell carcinoma (BCC) being most common and cutaneous squamous (cSCC) second. Prolonged ultraviolet (UV) exposure, aging, male gender, immunosuppression represent causes this category diseases. BCCs cSCCs both include different types such as nodular or morpheaform BCC flat cSCC. Locally advanced metastatic NMSCs cannot be treated surgically; thus, systemic therapy (TKI Immunotherapy) is needed. Interestingly, are frequently linked to abnormal Hedgehog (HH) signaling which immunotherapies for these based upon. Of note, first line therapies BCC, sonidegib vismodegib, HH inhibitors. Programmed death receptor 1 antibody (PD-1) inhibitors cemiplimab, pembrolizumab, nivolumab have been approved treatment Thus, paper reviews epidemiology, risk factors, clinical features, options

Язык: Английский

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Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)

International Journal of Oncology, Год журнала: 2024, Номер 65(6)

Опубликована: Окт. 22, 2024

Significant advancements have been made in cancer therapy; however, limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and the treatment outcomes of patients. Modern lifestyles contribute deficiencies melatonin vitamin D. Limited sun exposure affects D synthesis, artificial light at night suppresses production. Both possess anti‑inflammatory, immune‑boosting anticancer properties, rendering them potential adjuvants interest. Studies suggest supplementation may address antioxidant imbalances lip, oral pharyngeal cancers. Moreover, promising results from breast, head neck, brain, osteosarcoma research indicate for tumor growth inhibition, improved survival, a better quality life patients cancer. The radioprotective properties another exciting area exploration, potentially enhancing radiotherapy effectiveness while reducing side effects. For its part, sleep‑promoting effects indirectly benefit by influencing immune system. Thus, prevalence highlights importance supplementation, as lower levels can worsen side‑effects treatments. present review explores combining synergistic therapy. These shown promise individually prevention treatment, combined warrant investigation. Therefore, large‑scale controlled trials crucial definitively determine optimal dosage, safety this combination improving lives

Язык: Английский

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Unravelling the prognostic and operative role of intratumoural microbiota in non‐small cell lung cancer: Insights from 16S rRNA and RNA sequencing

Clinical and Translational Medicine, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 1, 2025

Abstract Background Complex interrelationships between the microbiota and cancer have been identified by several studies. However, despite delineating microbial composition in non‐small cell lung (NSCLC), key pathogenic their underlying mechanisms remain unclear. Methods We performed 16S rRNA V3–V4 amplicon transcriptome sequencing on cancerous adjacent normal tissue samples from 30 patients with NSCLC, which clinical characteristics prognosis outcomes were collected. used to dissect perform correlations, conjunction sequencing, we determined potential underpinning significant actions. Results In comparing different sample types, more pronounced beta diversity disparity squamous carcinoma (LUSC) corresponding paired tissues. Concurrently, LUSC adenocarcinoma exhibited distinct traits at genus levels. Subsequently, four phyla, five classes, nine orders, 17 families 36 genera filtered out related outcomes. Intriguingly, a protective cluster was encompassing associated delayed disease recurrence, functional analyses suggested that these predominantly exerted metabolism‐related functions. Additionally, harmful (HMC) identified, including three genera. this HMC subsequent model analyses, intratumoural potentially implicated infection, inflammation immune regulation. Crucially, genus, Peptococcus , as an independent, detrimental NSCLC prognostic factor impacted via tumour necrosis (TNF) signalling. Conclusions substantial connection Protective primarily metabolic functions, whereas mainly modulation. Furthermore, may be adverse prognoses serve biomarker for patient management screening. Key points Four found prognosis. recurrence shorter survival earlier recurrence. impacting TNF

Язык: Английский

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1,25(OH)₂D₃ Regulates Androgen Synthesis via Transcriptional Control of Steroidogenic Enzymes and LHR in the Scented Glands of Muskrats (Ondatra zibethicus)

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Vitamin D Binding Protein Gene Polymorphisms (rs4588 and rs7041) and VDBP Levels in Total Hip Replacement Outcomes

Nutrients, Год журнала: 2025, Номер 17(3), С. 378 - 378

Опубликована: Янв. 21, 2025

Background: Total hip replacement (THR) significantly improves patients’ quality of life; however, prosthesis loosening remains a significant complication. Vitamin D, essential for calcium homeostasis and bone mineralization, is transported stabilized by vitamin D binding protein (VDBP). Common single nucleotide polymorphisms (SNPs) in the VDBP gene, rs4588 rs7041, may influence serum levels potentially impact THR outcomes. This study aimed to analyze association between these SNPs, 25(OH)D, their potential roles Methods: The included three patient groups: (1) patients undergoing arthroscopy after without (CA—Control Arthroplasty), (2) with (L—Loosening), (3) control group (C—Control). Genotyping rs7041 gene was conducted using PCR-RFLP TaqMan real-time PCR. Serum 25(OH)D were measured ELISA. Comparisons groups performed statistical analyses, including odds ratios (OR) significance testing (p-values). Results: There are differences concentrations L vs. CA (p < 0.0001), C = 0.0118), + 0.0013), 0.0008), 0.0001). Conclusions: findings suggest protective role against THR. SNP increase risk loosening, while highlight importance

Язык: Английский

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Melatonin Pre-Treatment Protects Erythrocytes Against Subsequent Oxidative Damage

Molecules, Год журнала: 2025, Номер 30(3), С. 658 - 658

Опубликована: Фев. 1, 2025

Research on the effects of melatonin erythrocyte deformability has yielded mixed results. While some studies reported improvements, others found no effect, and a few even noted deterioration in deformability. Moreover, impact may vary between healthy erythrocytes those subjected to oxidative stress. This study investigated dose-dependent under baseline conditions stress, using both pre- post-stress incubation protocols. Oxidative damage was induced with tert-butyl hydroperoxide (TBHP), its extent assessed via dichlorofluorescein fluorescence. Erythrocyte measured ektacytometry, osmotic resistance through hemolytic assays. The results showed that TBHP led decline resistance. treatment had observable effect intact erythrocytes, it enhanced oxidatively damaged when administered before stress induced. However, beneficial not evident applied after damage. Additionally, ability resist hypotonic environment. In conclusion, this supports notion antioxidant properties can improve functional status, as reflected by deformability, but Notably, observed only were exposed incubation, cells.

Язык: Английский

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