International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
55(3)
Опубликована: Дек. 31, 2024
Iron
metabolism
plays
a
crucial
role
in
the
tumor
microenvironment,
influencing
various
aspects
of
cancer
cell
biology
and
progression.
This
review
discusses
regulatory
mechanisms
iron
within
microenvironment
highlights
how
cells
associated
stromal
manage
uptake,
accumulation
regulation.
The
sources
tumors
biological
importance
ferroptosis
were
explored,
focusing
on
its
mechanisms,
effects
and,
particular,
tumor‑suppressive
properties.
Furthermore,
protective
strategies
employed
by
to
evade
examined.
also
delves
into
intricate
relationship
between
immune
modulation
detailing
impact
tumor‑associated
evasion.
interplay
immunotherapy
is
discussed
potential
enhance
modulating
are
presented.
Finally,
current
ferroptosis‑based
therapeutic
approaches
summarized
future
directions
for
therapies
that
target
proposed.
Applied Sciences,
Год журнала:
2025,
Номер
15(2), С. 796 - 796
Опубликована: Янв. 15, 2025
Vitamin
D,
also
called
the
“sunshine”
vitamin,
has
gained
great
attention
recently
due
to
observed
high
percentage
of
worldwide
population
being
deficient
in
this
essential
bioactive
vitamin.
Primarily,
vitamin
D
was
known
for
its
important
role
bone
health.
Nevertheless,
recent
research
shown
importance
brain,
heart,
muscles,
immune
system,
and
skin
health,
distinct
bio-functionality
almost
every
tissue
human
body.
Therefore,
deficiency
been
highly
correlated
with
multiple
diseases,
including
dermatologically
associated
ones.
Moreover,
different
methodologies
are
applied
synthesize
while
main
sources
plasma
levels
factors
that
can
cause
adverse
modifications
multiple.
Further
upon
exhibited
notable
against
such
as
psoriasis,
atopic
dermatitis,
vitiligo,
acne,
rosacea.
In
article,
a
critical
review
most
relevant
significant
information
regarding
relationship
between
health
is
thoroughly
conducted,
emphasis
given
potential
uses
benefits
several
cosmetic
applications.
Current
status,
limitations,
future
perspectives
potent
extensively
discussed.
Journal of Cellular and Molecular Medicine,
Год журнала:
2025,
Номер
29(3)
Опубликована: Янв. 28, 2025
Tumour
cells
possess
a
multitude
of
chemoresistance
mechanisms,
which
could
plausibly
contribute
to
the
ineffectiveness
chemotherapy.
O6-methylguanine-DNA
methyltransferase
(MGMT)
is
an
important
effector
protein
associated
with
Temozolomide
(TMZ)
resistance
in
various
tumours.
To
some
extent,
expression
level
MGMT
determines
sensitivity
TMZ,
but
mechanism
its
regulation
has
not
been
fully
elucidated.
Cultured
malignant
melanoma
cell
lines
A375
and
Sk-MEL28
were
employed.
A
luciferase
assay
was
used
detect
transcriptional
activity
promoter.
Western
blotting
compare
levels
phosphorylated
ERK1/2
(P-ERK1/2)
after
TMZ
treatment.
Immunofluorescent
staining
TMZ-induced
DNA
damage
levels.
The
detected
by
MTT
animal
experiments.
mRNA
tested
Quantitative
real-time
PCR
(RT-qPCR).
Flow
cytometry
measure
apoptosis
TMZ-treated
cells.
enhanced
transcription
through
activating
ERK
pathway.
inhibitors
U0126
vemurafenib
(vMF)
inhibited
induced
MGMT.
p-ERK1/2
closely
related
human
MM
tissues.
vMF
increased
(MM)
vitro
vivo
downregulating
promoting
MM.
TMZ-promoted
contributed
instinctive
signalling
pathway
melanoma.
Our
study
indicates
that
use
inhibitor
combination
potentially
enhance
effectiveness
clinical
treatment
for
Molecules,
Год журнала:
2025,
Номер
30(4), С. 788 - 788
Опубликована: Фев. 8, 2025
Increasing
attention
is
being
focused
on
skin
health
currently,
especially
the
excessive
deposition
of
melanin
in
skin.
Tyrosinase,
rate-limiting
enzyme
biosynthesis,
a
crucial
synthesis.
However,
existing
tyrosinase
inhibitors
pose
some
degree
toxicity
to
humans.
Therefore,
development
more
efficient
and
low-toxicity
urgently
needed.
This
review
briefly
depicts
biosynthesis
process
crystal
structure
catalytic
mechanism
tyrosinase.
The
latest
research
progress
regarding
small-molecule
also
reviewed.
Moreover,
structure-function
relationships
are
analyzed
summarized.
expected
provide
new
scientific
insights
enable
researchers
explore
safer
potent
inhibitors.
Cells,
Год журнала:
2025,
Номер
14(7), С. 534 - 534
Опубликована: Апрель 2, 2025
Changes
in
skin
pigmentation,
like
hyperpigmentation
or
moles,
can
affect
appearance
and
social
life.
Unlike
locally
containable
malignant
melanomas
are
aggressive
spread
rapidly,
disproportionately
affecting
younger
individuals
with
a
high
potential
for
metastasis.
Research
has
shown
that
the
peroxisome
proliferator-activated
receptor
gamma
(PPAR-γ)
its
ligands
exhibit
protective
effects
against
melanoma.
As
transcription
factor,
PPAR-γ
is
crucial
functions
fatty
acid
storage
glucose
metabolism.
Activation
of
promotes
lipid
uptake
enhances
sensitivity
to
insulin.
In
many
cases,
it
also
inhibits
growth
cancer
cell
lines,
breast,
gastric,
lung,
prostate
cancer.
melanoma,
regulates
proliferation,
differentiation,
apoptosis,
survival.
During
tumorigenesis,
controls
metabolic
changes
immunogenicity
stromal
cells.
agonists
target
hypoxia-induced
angiogenesis
tumor
therapy,
but
their
on
tumors
be
suppressive
promotional,
depending
environment.
Published
data
show
PPAR-γ-targeting
agents
effective
specific
groups
patients,
further
studies
needed
understand
lesser-known
biological
address
existing
safety
concerns.
This
review
provides
summary
current
understanding
involvement
Medicina,
Год журнала:
2025,
Номер
61(4), С. 656 - 656
Опубликована: Апрель 2, 2025
Neoplastic
disorders,
particularly
malignant
carcinomas,
are
complex
systemic
diseases
characterized
by
unregulated
cellular
proliferation,
the
invasion
of
adjacent
tissues,
and
potential
metastasis
to
distant
bodily
sites.
Among
diverse
spectrum
cancer
subtypes,
melanoma
is
a
highly
aggressive
form
cutaneous
originating
in
melanocytes,
pigment-producing
cells
resident
skin.
This
malignancy
distinguished
its
rapid
uncontrolled
growth,
as
well
propensity
for
vital
organs,
thereby
posing
significant
challenges
therapeutic
intervention
prognostication.
Early
detection
crucial
optimizing
patient
outcomes,
diagnosis
at
an
advanced
stage
often
yields
poor
prognosis
limited
treatment
options.
Diagnostic
modalities
encompass
comprehensive
clinical
evaluations
dermatologists;
radiological
imaging
techniques
such
ultrasonography,
magnetic
resonance
(MRI),
computed
tomography
(CT)
scans;
excisional
biopsies
accurate
histopathological
assessment.
Malignant
typically
treated
with
surgery
remove
tumor,
followed
immunotherapy
enhance
immune
response,
targeted
therapy
tumors
specific
genetic
mutations,
chemotherapy
stages,
radiation
manage
metastasis,
other
adjunct
therapies.
review
presents
properties
possible
effects
against
quercetin
found
literature
explores,
based
on
observed
physicochemical
biological
activity,
development
topical
formulation
application.
Quercetin
naturally
occurring
flavonoid
compound
abundant
various
plant-based
food
sources,
including
apples,
onions,
berries,
citrus
fruits,
has
exhibited
promising
antiproliferative,
antioxidant,
anticancer
properties.
Its
distinctive
biochemical
structure
enables
effectively
neutralize
reactive
oxygen
species
modulate
key
carcinogenic
pathways,
rendering
it
candidate
managing
tumors,
melanoma.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3475 - 3475
Опубликована: Апрель 8, 2025
Melanoma,
one
of
the
most
lethal
cancers,
demands
urgent
and
effective
treatment
strategies.
However,
a
successful
therapeutic
approach
requires
precise
understanding
mechanisms
underlying
melanoma
initiation
progression.
This
review
provides
an
overview
pathogenesis,
identifies
current
pathogenic
factors
contributing
to
mortality,
explores
targeted
therapy
checkpoint
inhibitor
therapy.
Furthermore,
we
examine
classification
corresponding
therapies,
along
with
advancements
in
various
cell
death
for
treatment.
We
also
discuss
status
some
drawbacks
encountered
during
research
stages
such
as
resistance
metastasis.
Medicina,
Год журнала:
2024,
Номер
60(8), С. 1239 - 1239
Опубликована: Июль 30, 2024
Background
and
Objectives:
Amelanotic/hypomelanotic
melanomas
(AHMs)
account
for
2–8%
of
all
cutaneous
melanomas.
Due
to
their
clinical
appearance
the
lack
specific
dermoscopic
indicators,
AHMs
are
challenging
diagnose,
particularly
in
thinner
lesions.
The
aim
our
study
was
evaluate
clinicopathological
features
thin
AHMs.
Identifying
baseline
clinical–pathological
aspects
is
crucial
better
understand
this
entity.
Materials
Methods:
We
divided
AHM
cohort
into
two
groups
based
on
Breslow
thickness:
(≤1.00
mm)
thick
(>1.00
mm).
This
stratification
helped
identify
any
significant
differences
between
groups.
For
analysis,
we
employed
“pattern
analysis”
approach,
which
involves
a
simultaneous
subjective
assessment
different
criteria.
Results:
Out
2.800
analyzed
thickness,
153
were
identified
as
Among
these,
65
patients
presented
with
88
Red
hair
color
phototype
II
more
prevalent
trunk
most
common
anatomic
site
Patients
showed
higher
number
multiple
Dermoscopic
analysis
revealed
no
difference
AHMs,
except
frequent
occurrence
residual
reticulum
Conclusions:
Thin
typically
affect
individuals
lower
phototypes
red
color.
These
can
be
related
presence
pheomelanin,
provides
limited
protection
against
sun
damage.
also
correlates
fact
that
trunk,
commonly
exposed
intermittent
exposure,
primary
anatomical
location
Multiple
likely
due
an
intrinsic
predisposition
well
greater
periodic
dermatologic
follow-ups
class
patients.
Apart
from
reticulum,
other
observed,
complicating
differential
diagnosis
dermoscopy
alone.
