International Journal of Molecular Medicine,
Год журнала:
2021,
Номер
47(5)
Опубликована: Фев. 26, 2021
There
is
a
growing
evidence
that
Fyn
kinase
upregulated
in
glioblastoma
multiforme
(GBM),
where
it
plays
key
role
tumor
proliferation
and
invasion.
In
the
present
study,
antitumor
effects
of
rosmarinic
acid
(RA),
inhibitor,
were
explored
human‑derived
U251
U343
glioma
cell
lines.
These
cells
treated
with
various
concentrations
RA
to
determine
its
on
proliferation,
migration,
invasion,
apoptosis,
gene
protein
expression
levels.
The
CCK‑8
assay
revealed
significantly
suppressed
viability
cells.
Furthermore,
reduced
rates,
inhibited
migration
decreased
levels
invasion‑related
factors,
such
as
matrix
metalloproteinase
(MMP)‑2
MMP‑9.
TUNEL
staining
resulted
dose‑dependent
increase
apoptosis.
line
this
finding,
apoptosis
suppressor
Bcl‑2
was
downregulated
pro‑apoptotic
proteins
Bax
cleaved
caspase‑3
increased.
addition,
phosphatidylinositol
3‑kinase
(PI3K)/Akt/nuclear
factor‑κB
(NF‑κB)
signaling
pathway
involved
RA‑induced
cytotoxicity
Collectively,
study
suggested
drug
candidate
for
treatment
GBM.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(4), С. 1488 - 1525
Опубликована: Янв. 30, 2023
Abstract
Regulated
cell
death
(RCD)
refers
to
programmed
regulated
by
various
protein
molecules,
such
as
apoptosis,
autophagy‐dependent
death,
and
necroptosis.
Accumulating
evidence
has
recently
revealed
that
RCD
subroutines
have
several
links
many
types
of
human
cancer;
therefore,
targeting
with
pharmacological
small‐molecule
compounds
would
be
a
promising
therapeutic
strategy.
Moreover,
plant
natural
compounds,
synthesized
from
sources,
their
derivatives
been
widely
reported
regulate
different
improve
potential
cancer
therapy.
Thus,
in
this
review,
we
focus
on
updating
the
intricate
mechanisms
necroptosis
cancer.
further
discuss
representative
above‐mentioned
three
RCD,
candidate
drugs
for
future
treatment.
Drug Design Development and Therapy,
Год журнала:
2023,
Номер
Volume 17, С. 821 - 836
Опубликована: Март 1, 2023
Background:
Breast
cancer
is
a
common
worldwide.
Triple-negative
breast
(TNBC)
an
aggressive
form
of
characterized
by
poor
prognosis.
Icariin
(ICA)
flavonoid
glycoside
purified
from
the
natural
product
Epimedium,
which
reported
to
exert
inhibitory
effect
on
variety
cancers.
However,
molecular
mechanisms
behind
ICA
suppressed
TNBC
remain
elusive.
Methods:
The
curative
effects
cells
and
potential
targets
were
predicted
network
pharmacology
biology
methods
screening,
mechanism
inhibition
was
explained
through
in
vitro
experiments
such
as
cell
function
determination,
Western
blot
analysis,
docking
verification,
etc.
Results:
This
study
showed
that
inhibits
functions
proliferation,
migration,
invasion
dose-dependent
manner.
could
induce
redox‐induced
apoptosis
cell,
shown
ROS
upregulation.
As
result
pharmacology,
be
able
inhibit
MAPK
signaling
pathway.
treatment
inhibited
expression
JNK
c-Jun
downregulated
antiapoptotic
gene
cIAP-2.
Our
results
suggested
inducing
excessive
accumulation
suppress
via
JNK/c-Jun
Conclusion:
We
demonstrated
can
effectively
proliferation
induced
cells.
In
addition,
above
suggests
may
become
drug
for
TNBC.
Keywords:
triple-negative
cancer,
icariin,
JNK/c-Jun,
apoptosis,
ROS,
Cancer and Metastasis Reviews,
Год журнала:
2023,
Номер
43(1), С. 87 - 113
Опубликована: Окт. 4, 2023
Abstract
Cancer
cell
plasticity
plays
a
crucial
role
in
tumor
initiation,
progression,
and
metastasis
is
implicated
the
multiple
cancer
defense
mechanisms
associated
with
therapy
resistance
evasion.
represents
one
of
significant
obstacles
clinical
management
cancer.
Some
reversal
chemosensitizing
agents
have
been
developed
to
resolve
this
serious
problem,
but
they
not
yet
proven
applicable
oncological
practice.
Activated
nuclear
factor
kappa
B
(NF-κB)
frequently
observed
biomarker
chemoresistant
breast
(BC).
Therefore,
it
denotes
an
attractive
cellular
target
mitigate
resistance.
We
summarize
that
flavonoids
represent
essential
class
phytochemicals
act
as
regulators
NF-κB
signaling
negatively
affect
fundamental
processes
contributing
acquired
drug
In
regard,
flavokawain
A,
icariin,
alpinetin,
genistein,
wogonin,
apigenin,
oroxylin
xanthohumol,
EGCG,
hesperidin,
naringenin,
orientin,
luteolin,
delphinidin,
fisetin,
norwogonin,
curcumin,
cardamonin,
methyl
gallate
catechin-3-O-gallate,
ampelopsin,
puerarin,
hyperoside,
baicalein,
paratocarpin
E,
kaempferol
also
synthetic
such
LFG-500
5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone
reported
specifically
interfere
pathway
complex
consequences
BC
cells
could
be
potentially
re-sensitizing
unresponsive
cases.
The
targeting
by
above-mentioned
includes
modification
microenvironment
epithelial-mesenchymal
transition,
growth
receptor
regulations,
modulations
specific
pathways
PI3K/AKT,
MAP
kinase/ERK,
Janus
kinase/signal
transduction
cells.
Besides
that,
modulated
has
involved
regulation
ATP-binding
cassette
transporters,
apoptosis,
autophagy,
cycle,
changes
activity
stem
cells,
oncogenes,
or
controlling
gene
repair.
evaluation
conventional
therapies
combination
plasticity-regulating/sensitizing
offers
new
opportunities
make
progress
towards
complete
cure
for
Graphical
abstract
Antioxidants,
Год журнала:
2021,
Номер
10(12), С. 1893 - 1893
Опубликована: Ноя. 26, 2021
The
impact
of
dietary
phytoestrogens
on
human
health
has
been
a
topic
continuous
debate
since
their
discovery.
Nowadays,
based
presumptive
beneficial
effects,
the
amount
consumed
in
daily
diet
increased
considerably
worldwide.
Thus,
there
is
growing
need
for
scientific
data
regarding
mode
action
body.
Recently,
new
insights
phytoestrogens’
bioavailability
and
metabolism
have
demonstrated
an
inter-and
intra-population
heterogeneity
final
metabolites’
production.
In
addition,
may
ability
to
modulate
epigenetic
mechanisms
that
control
gene
expression.
This
review
highlights
complexity
particularity
each
class
phytoestrogens,
pointing
out
diversity
bioactive
gut
metabolites.
Futhermore,
it
presents
emerging
which
suggest
that,
among
well-known
genistein
resveratrol,
other
metabolites
can
act
as
modulators
with
possible
health.
interconnection
consumption
microbiota
composition,
epigenome
related
preventive
discussed.
current
challenges
future
perspectives
designing
relevant
research
directions
explore
potential
benefits
are
also
explored.
International Journal of Molecular Medicine,
Год журнала:
2021,
Номер
47(5)
Опубликована: Фев. 26, 2021
There
is
a
growing
evidence
that
Fyn
kinase
upregulated
in
glioblastoma
multiforme
(GBM),
where
it
plays
key
role
tumor
proliferation
and
invasion.
In
the
present
study,
antitumor
effects
of
rosmarinic
acid
(RA),
inhibitor,
were
explored
human‑derived
U251
U343
glioma
cell
lines.
These
cells
treated
with
various
concentrations
RA
to
determine
its
on
proliferation,
migration,
invasion,
apoptosis,
gene
protein
expression
levels.
The
CCK‑8
assay
revealed
significantly
suppressed
viability
cells.
Furthermore,
reduced
rates,
inhibited
migration
decreased
levels
invasion‑related
factors,
such
as
matrix
metalloproteinase
(MMP)‑2
MMP‑9.
TUNEL
staining
resulted
dose‑dependent
increase
apoptosis.
line
this
finding,
apoptosis
suppressor
Bcl‑2
was
downregulated
pro‑apoptotic
proteins
Bax
cleaved
caspase‑3
increased.
addition,
phosphatidylinositol
3‑kinase
(PI3K)/Akt/nuclear
factor‑κB
(NF‑κB)
signaling
pathway
involved
RA‑induced
cytotoxicity
Collectively,
study
suggested
drug
candidate
for
treatment
GBM.
