Biochemical Genetics, Год журнала: 2023, Номер 62(2), С. 761 - 774
Опубликована: Июль 10, 2023
Язык: Английский
Archives of Pharmacal Research, Год журнала: 2022, Номер 45(4), С. 205 - 228
Опубликована: Апрель 1, 2022
Язык: Английский
Процитировано
147
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114687 - 114687
Опубликована: Апрель 14, 2023
Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse
Язык: Английский
Процитировано
66
Biomolecules, Год журнала: 2022, Номер 12(10), С. 1410 - 1410
Опубликована: Окт. 2, 2022
Cancer constitutes a severe threat to human health and quality of life is one the most significant causes morbidity mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment prevention due their availability absence toxicity. Rosmarinic acid (RA) known for its excellent antioxidant properties safe effective preventing inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, anti-tumor applications RA-enriched supplements. We discuss techniques improve RA bioavailability provide mechanistic discussion regarding tumor prevention, treatment, adjuvant therapy. exhibits anticancer activity by regulating oxidative stress, chronic inflammation, cell cycle, apoptosis, metastasis. These data suggest that daily use supplements can contribute treatment. has potential application drug development.
Язык: Английский
Процитировано
47
Molecules, Год журнала: 2023, Номер 28(3), С. 1193 - 1193
Опубликована: Янв. 25, 2023
In most cases, cancer develops due to abnormal cell growth and subsequent tumour formation. Due significant constraints with current treatments, natural compounds are being explored as potential alternatives. There now around 30 under clinical trials for the treatment of cancer. Tulsi, or Holy Basil, genus Ocimum, is one widely available cost-effective medicinal plants. India, tulsi plant has deep religious significance. Tulsi essential oil contains a valuable source bioactive compounds, such camphor, eucalyptol, eugenol, alpha-bisabolene, beta-bisabolene, beta-caryophyllene. These proposed be responsible antimicrobial properties leaf extracts. The anticancer effects (Ocimum sanctum L.) have earned it title “queen herbs” “Elixir Life” in Ayurvedic treatment. leaves, which high concentrations been shown properties. various cancers, eugenol exerts its antitumour through number different mechanisms. light this, review focuses on benefits primary phytoconstituent, apotential therapeutic agent against wide range types. recent years, gained popularity ongoing trials, evaluated their effects. This article discusses anticancer, chemopreventive, antioxidant tulsi.
Язык: Английский
Процитировано
31
Small, Год журнала: 2023, Номер 19(23)
Опубликована: Фев. 8, 2023
A primary concern about photodynamic therapy (PDT) is its inability to regulate the generation levels of reactive oxidative species (ROS) based on complex microenvironment, resulting in impairment toward normal tissues and immunosuppression. Besides, tumor metastasis also compromises PDT's efficacy drives mortality. However, it very challenging achieve such two goals within one nanosystem. Here, nanoassembly (CPR) with self-regulated antimetastasis properties comprises three parts: chlorin e6-conjugated β-cyclodextrin (CD-Ce6) acts as main PDT agent ferrocene (Fc)-terminated phenylboronic acid-containing conjugates entering into cavity CD-Ce6, well rosmarinic acid (RA)-boronic crosslinked shell. Compared non-crosslinked counterpart, CPR displays better stability enhanced accumulation. Under laser irradiation, generates plenty ROS damage cells induce immunogenic cell death. Mildly acidic TME partly cleaves crosslinkers dissociate antioxidant RAs from micelles, which together Fc scavenge PDT-induced TME. By contrast, under lysosomal conditions, catalyzes abundant H2 O2 produce highly cytotoxic •OH, while RA continuously reduces ferroptosis-generated Fc+ Fc, both augment cells. remarkably hinders epithelial-mesenchymal transition prevent lung metastasis.
Язык: Английский
Процитировано
24
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 10337 - 10337
Опубликована: Июнь 19, 2023
Glioblastoma multiforme (GBM) is the most common and invasive primary central nervous system tumor in humans, accounting for approximately 45–50% of all brain tumors. How to conduct early diagnosis, targeted intervention, prognostic evaluation GBM, order improve survival rate glioblastoma patients, has always been an urgent clinical problem be solved. Therefore, a deeper understanding molecular mechanisms underlying occurrence development GBM also needed. Like many other cancers, NF-κB signaling plays crucial role growth therapeutic resistance GBM. However, mechanism high activity remains elucidated. This review aims identify summarize involved recent pathogenesis as well basic therapy via signaling.
Язык: Английский
Процитировано
24
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Янв. 18, 2024
Gliomas are prevalent malignant tumors in adults, which can be categorized as either localized or diffuse gliomas. Glioblastoma is the most aggressive and deadliest form of glioma. Currently, there no complete cure, median survival time less than one year. The main mechanism regulated cell death involves organisms coordinating elimination damaged cells at risk tumor transformation hijacked by microorganisms for pathogen replication. This process includes apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, necrosis, parthanayosis, entosis, lysosome-dependent death, NETosis, oxiptosis, alkaliptosis, disulfidaptosis. goal clinical oncology to develop therapies that promote effective cancer regulating oncology. Recently, scientists have utilized pertinent regulatory factors natural small-molecule compounds induce treatment By analyzing PubMed Web Science databases, this paper reviews research progress on regulation role aim provide help glioblastoma.
Язык: Английский
Процитировано
12
Nutrients, Год журнала: 2023, Номер 15(19), С. 4297 - 4297
Опубликована: Окт. 9, 2023
Phytochemicals are abundantly occurring natural compounds extracted from plant sources. Rosmarinic acid (RA) is an abundant phytochemical of Lamiaceae species with various therapeutic implications for human health. In recent years, have gained significant attention as adjuvant and complementary therapies to existing medications diseases. RA has popularity due its anti-inflammatory antioxidant properties roles in life-threatening conditions, such cancer, neurodegeneration, diabetes, etc. The present review aims offer a comprehensive insight into the multifaceted RA, including potential anticancer agent, neuroprotective effects, antidiabetic potential. Based on available evidences, could be considered dietary component treating diseases, diabetes neurodegenerative disorders.
Язык: Английский
Процитировано
20
Molecules, Год журнала: 2024, Номер 29(8), С. 1843 - 1843
Опубликована: Апрель 18, 2024
Purpose: To investigate and systematically describe the mechanism of action Prunella vulgaris (P. vulgaris) against digestive system tumors related toxicity reduction. Methods: This study briefly describes history medicinal food pharmacological effects P. vulgaris, focusing on review anti-digestive tumor active ingredients its Results: The may exert anti-tumor by inducing apoptosis cancer cells, inhibiting angiogenesis, migration invasion autophagy. In addition, inhibit release inflammatory factors macrophages increase level indicators oxidative stress through modulation target genes in pathway to achieve effect Conclusion: medicine homology plant not only treat different mechanisms but also reduce toxic effects. is worthy being explored more deeply.
Язык: Английский
Процитировано
7
Biomolecules & Therapeutics, Год журнала: 2023, Номер 32(1), С. 38 - 55
Опубликована: Дек. 27, 2023
Fazila Sirajudeen, Lara J. Bou Malhab, Yasser Bustanji, Moyad Shahwan, Karem H. Alzoubi, Mohammad Semreen, Jalal Taneera, Waseem El-Huneidi and Eman Abu-Gharbieh. Biomolecules & Therapeutics 2024;32:38-55. https://doi.org/10.4062/biomolther.2023.054
Язык: Английский
Процитировано
14