FERMT1 Is a Prognostic Marker Involved in Immune Infiltration of Pancreatic Adenocarcinoma Correlating with m6A Modification and Necroptosis

Genes, Год журнала: 2023, Номер 14(3), С. 734 - 734

Опубликована: Март 16, 2023

As an important member of the kindlin family, fermitin family 1 (FERMT1) can interact with integrin and its aberrant expression involves multiple tumors. However, there are few systematic studies on FERMT1 in pancreatic carcinoma (PAAD). We used several public databases to analyze level clinicopathological characteristics PAAD. Meanwhile, correlation between diagnostic prognostic value, methylation, potential biological function, immune infiltration, sensitivity chemotherapy drugs PAAD patients were investigated. was significantly up-regulated correlated T stage, histologic grade. High closely connected poor prognosis be diagnose Moreover, methylation six CpG sites linked prognosis, related N6-methyladenosine (m6A) modification. Functional enrichment analysis revealed that co-expression genes participated diverse functions including necroptosis. In addition, associated cell infiltration checkpoint molecules. Finally, overexpression may sensitive such as Palbociclib, AM-5992 TAE-226. serve a marker PAAD, which is modulation m6A

Язык: Английский

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Analysing the Anticancer Properties of Pterostilbene Through Absorption, Distribution, Metabolism, and Excretion (ADME) and Molecular Docking Studies

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Апрель 16, 2024

Aim The aim of this study is to examine the possible therapeutic effect pterostilbene (PTS), a chemical present in grapes and blueberries, treatment liver cancer by analysing its interactions with important proteins linked wingless/integrated (Wnt) signaling system. Objective Using computational techniques like molecular docking absorption, distribution, metabolism, excretion (ADME) studies, research focuses on examining pharmacokinetics PTS such as vimentin (Vim), glycogen synthase kinase 3 beta (GSK3-β), epithelial cadherin (E-cadherin), interleukin-6 (IL-6), interleukin-1 (IL-1β), c-Jun N-terminal (JNK), Wnt, all which are connected Wnt pathway cancer. Methods includes synthesis ligands, ADME investigations for PTS, AutoDock Vina simulations evaluate binding affinities interactions. obtained from PubChem, while protein structures Protein Data Bank. Results Strong between essential cascade shown docking, also highlights noteworthy hydrogen bonds, hydrophobic interactions, electrostatic contacts. According an study, has advantageous pharmacokinetic properties, moderate solubility, membrane permeability, minimal chance drug Conclusion extensive PTS's potential viable option promotes investigation cutting-edge therapy approaches urges more into mechanisms, underpinning anticancer properties. This paper sheds light role natural chemicals emphasizes need methods discovery.

Язык: Английский

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Strategies for enhancing non-small cell lung cancer treatment: Integrating Chinese herbal medicines with epidermal growth factor receptor-tyrosine kinase inhibitors therapy

European Journal of Pharmacology, Год журнала: 2024, Номер 980, С. 176871 - 176871

Опубликована: Авг. 6, 2024

Язык: Английский

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Clinical Significance of Telomerase Reverse-Transcriptase Promoter Mutations in Hepatocellular Carcinoma

Cancers, Год журнала: 2021, Номер 13(15), С. 3771 - 3771

Опубликована: Июль 27, 2021

Telomerase reactivation during hepatocarcinogenesis is recurrently caused by two point mutations occurring most frequently at the nucleotide −124 (95%) and occasionally −146 (<5%) upstream of TERT translational start site in hepatocellular carcinoma (HCC). In this study, we designed a droplet digital PCR (ddPCR) assay to detect promoter (TERTp) change G>A position quantify mutant allele frequency (MAF) 121 primary liver cancers, including 114 HCC along with 23 autologous cirrhotic tissues, five cholangiocarcinoma (CC), hepato-cholangiocarcinoma (HCC-CC). All cases were evaluated for tumour markers such as α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), carcinoembryonic (CEA). We compared sensitivity ddPCR Sanger sequencing investigated prognostic relevance TERTp mutations. The transition was identified 63.6% 52.1% samples sequencing, respectively. One out (4.3%) peri-tumour tissues tested positive only ddPCR. CC (20%) none HCC-CC found concordantly mutated methods. MAF ranged from 2% 66%, large majority (85.5%) showed value above 20%. A statistically significant correlation between mutation size (p = 0.048), while an inverse observed CA19-9 levels 0.0105). Moreover, patients −124A had reduced survival. conclusion, single variation TERTp, detected either or remarkable high HCC. Such associated lower survival suggesting that status may represent distinct signature cancer subgroups.

Язык: Английский

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The progress of research on immune checkpoint inhibitor resistance and reversal strategies for hepatocellular carcinoma

Cancer Immunology Immunotherapy, Год журнала: 2023, Номер 72(12), С. 3953 - 3969

Опубликована: Ноя. 2, 2023

Язык: Английский

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