RSC Advances, Год журнала: 2024, Номер 14(48), С. 35323 - 35335
Опубликована: Янв. 1, 2024
Synthesis and cytotoxicity evaluation of novel benzimidazoles were explained. The most potent derivative was subjected to cell cycle, apoptosis, in silico investigations. Compound 5o proved be a promising anticancer agent.
Язык: Английский
Heliyon, Год журнала: 2024, Номер 10(16), С. e35989 - e35989
Опубликована: Авг. 1, 2024
The WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse, metastasis, drug resistance, tumor stemness maintenance. In most tumors, the is often aberrantly activated. therapeutic usefulness of inhibition has been reported to improve efficiency different cancer treatments this carried out using methods including pharmacological agents, short interfering RNA (siRNA), antibodies. Here, we review WNT-inhibitory effects some FDA-approved drugs natural products treatment focus on recent progress WNT inhibitors improving chemotherapy, immunotherapy, gene therapy, physical therapy. We also classified these according their structure physicochemical properties, introduced briefly potential mechanisms inhibiting pathway. provides a comprehensive understanding various therapeutics. This will benefit novel inhibitor development optimal clinical use signaling-related synergistic
Язык: Английский
Процитировано
8
Heliyon, Год журнала: 2025, Номер 11(3), С. e42105 - e42105
Опубликована: Янв. 22, 2025
In the present study, novel benzimidazole compounds are synthesized, utilizing Suzuki coupling and acid-amine reaction. The formation of all synthesized derivatives was confirmed through various spectroscopic techniques, including 1H, 13C, Carbon DEPT-135, H-H COSY, HSQC, HRMS. UV-Vis fluorescence spectra were recorded. Particularly, among compounds, compound 9o (304.06 nm) exhibited higher λmax in spectroscopy, while 9j (396.16 highest emmision intensity spectroscopy. Furthermore, density functional theory (DFT) calculations performed at B3LYP/6-31G'(d,p) foundational level set. These aimed to predict chemical reactivity newly by assessing parameters such as HOMO-LUMO energy gap value, ionization potential, electrostaic electron affinity, electronegativity, global hardness, softness values. Subsequently, a molecular docking analysis on protein associated with Bcl-2 conjunction venetoclax, 9g (-10.77 kcal/mol) indicating most significant binding affinity investigated.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Development of benzimidazole-based salicylic acid derivatives as novel fluorophores:Identification the representative 5q with excellent SHP1 inhibition and obvious fluorescence specificity for Fe 3+ .
Язык: Английский
Процитировано
1
ChemistrySelect, Год журнала: 2023, Номер 8(47)
Опубликована: Дек. 13, 2023
Abstract Nitrogen‐containing heterocycles such as imidazoles, thiazoles, and oxazoles play a significant role in the fields of biological pharmaceutical chemistry. These compounds were widely used for agrochemical, pesticide, medicinal, industrial applications. Due to wide spectrum structural diversity well activity N ‐heterocycles, plethora reports on their synthesis have appeared last few decades. However, developments various bond‐forming strategies C−C, C−N, C−O, C−S, N−N, C−H activation, been powerful synthetic tool derive copious ‐heterocycles. The most prominent fascinating imidazole, thiazole, oxazoles, benzimidazole moieties by C−C C−N coupling reactions, multi‐component cycloaddition etc. are discussed this study. studies demonstrated enormous potential methods accelerating modern chemical establishing molecular beauty through bonding. aspects methodologies, like optimized conditions, substrate scope, mechanistic investigations, detail.
Язык: Английский
Процитировано
19
Beilstein Journal of Organic Chemistry, Год журнала: 2025, Номер 21, С. 234 - 241
Опубликована: Янв. 30, 2025
An efficient and eco-friendly approach for synthesizing difluoromethyl- aryldifluoromethyl-substituted polycyclic imidazoles was established via a visible-light-promoted radical cyclization reaction. This method employed the readily accessible inexpensive CF 2 HCO H or PhCF COOH, along with benzimidazoles bearing unactivated alkenes PhI(OAc) as substrates, proceeded without need of any base, metal catalyst, photocatalyst additive. In total, 24 examples were examined, all them successfully underwent reaction to produce target products in good excellent yields. Mechanistic studies revealed that proceeds pathway.
Язык: Английский
Процитировано
0
Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(4)
Опубликована: Апрель 1, 2025
ABSTRACT A series of benzimidazolium chlorides ( 2a‐c ) and their corresponding 2‐mercapto derivatives 3a‐c were proficiently synthesized analyzed by NMR LC‐MS spectra. The in vitro cytotoxic assay demonstrated that some compounds active on the cancer cell lines. binding potential most three to topoisomerase II alpha (topo2α) was explored unveil possible mode action for activity. examined through molecular docking. stability compound‐enzyme complexes from docking investigated dynamics (MD) simulation. study revealed showed ability bind enzyme. However, strength weaker than standard drug, doxorubicin. MD simulation analysis 3a 3b gave relatively stable with enzyme thus they would remain inside pocket during period. Furthermore, pharmacokinetic properties computed silico . computation disclosed all exhibited drug‐like properties. It is worth mentioning them found be nontoxic. In furtherance, inhibitory effect quorum sensing system inspected using biomonitor strains Chromobacterium violaceum 026, Chromobacterium. VIR07 Pseudomonas aeruginosa PAO1. this regard, we focused appraisal virulence factors, including pyocyanin, elastase, biofilm formation are created P. PAO1 as source infectious diseases. As a result, it determined displayed statistically significant inhibition effects, highest activity observed elastase production an rate 84–86%.
Язык: Английский
Процитировано
0
Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(5)
Опубликована: Апрель 9, 2025
ABSTRACT The detection of Fe(III) ions and monitoring pH conditions are vital for safety, efficiency, sustainability in scientific research, environmental management, industrial applications. In this study, two 1,2‐biphenyl‐substituted benzimidazole‐1,2,3‐triazole hybrids, Pact Oact, were designed, developed, characterized by various spectroscopic techniques including single‐crystal XRD analysis. demonstrated high sensitivity selectivity towards under physiological pH, confirmed through visual tests, UV–visible, fluorescence spectroscopy, with limits (LOD) 0.3 (emission) 0.07 nM (absorption). A 1:1 ligand‐to‐metal binding ratio was established Job's plot supported NMR, mass, VSM, FT‐IR analyses. RGB tool (LOD: 3.4 mM) a paper kit test its portable reversible nature, validated EDTA suggesting potential molecular logic gate Environmental highlighted real water sample analysis, while DFT calculations identified favorable metal sites. Additionally, exhibited highly acidic conditions, containing nitro group, showed superior vitro anticancer activity against HeLa cells compared to Pact, higher score (−9.10 kcal/mol vs. −8.63 kcal/mol) docking studies the breast cancer estrogen receptor mutant L536S (PDB ID: 6sbo). Antioxidant assays further Oact's enhanced radical scavenging potential.
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2024, Номер 9(26), С. 28129 - 28143
Опубликована: Июнь 19, 2024
An efficient and mild protocol for the visible light-induced radical cascade difluoromethylation/cyclization of imidazoles with unactivated alkenes using easily accessible bench-stable difluoromethyltriphenylphosphonium bromide as precursor -CF
Язык: Английский
Процитировано
4
Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер unknown, С. 130167 - 130167
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2024, Номер 664, С. 124473 - 124473
Опубликована: Июль 17, 2024
Язык: Английский
Процитировано
3