Comorbidity of rheumatoid arthritis and periodontal diseases DOI Creative Commons
Д. И. Трухан,

Anatoly F. Sulimov,

L. Yu. Trukhan

и другие.

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 5, С. 288 - 297

Опубликована: Май 13, 2024

A growing body of evidence suggests that periodontal pathology, accompanied by oral inflammation and pathological changes in the microbiome, induces gut microbiome (oral-gut axis) is involved pathogenesis systemic diseases. This review focuses on published literature, with an emphasis last decade, assessing whether disease, primarily periodontitis, periodontopathic bacteria are risk factors for development rheumatoid arthritis. The examines bilateral connections between arthritis highlights main links this connection. Porphyromonas gingivalis other may contribute to inflammatory diseases remodeling normally benign microbiota into a dysbiotic one. expresses endogenous citrullinated proteins its own unique bacterial enzyme, peptidyl arginine deminase, leading formation cyclic peptide autoantibodies impaired immunotolerance susceptible patients. Results from clinical studies suggest people periodontitis infection at developing arthritis, supporting findings experimental studies. Non-surgical treatment likely effective controlling reducing disease activity (primarily DAS28 ESR). These observations highlight importance health need prevention early patients

Язык: Английский

Identification of Nutritional Factors to Evaluate Periodontal Clinical Parameters in Patients with Systemic Diseases DOI Open Access
Yohei Nakayama, Shinichi Tabe, Arisa Yamaguchi

и другие.

Nutrients, Год журнала: 2023, Номер 15(2), С. 365 - 365

Опубликована: Янв. 11, 2023

Nutritional factors reflect the periodontal parameters accompanying status. In this study, associations between nutritional factors, blood biochemical items, and clinical were examined in patients with systemic diseases. The study participants 94 heart disease, dyslipidemia, kidney or diabetes mellitus. Weak negative correlation coefficients found nine ten factors. Stage, grade, mean probing depth (PD), rate of PD 4−5 mm, ≥ 6 attachment level (CAL), bleeding on (BOP) weakly correlated various determinations (R2) > 0.1 number teeth, PD, CAL, BOP rate. was explained by yogurt cabbage statistically significant standardized partial regression (yogurt: −0.2143; napa cabbage: −0.2724). CAL pork, beef, mutton, dark green vegetables (−0.2237 for mutton; −0.2667 vegetables). These results raise possibility that frequency intake can be used to evaluate stabilization

Язык: Английский

Процитировано

1

Ligneous periodontitis exacerbated by Behçet’s disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C > T: a case report DOI Creative Commons
Yuki Shinoda-Ito,

Anna Hirai,

Kazuhiro Omori

и другие.

BMC Oral Health, Год журнала: 2023, Номер 23(1)

Опубликована: Ноя. 8, 2023

Plasminogen serves as the precursor to plasmin, an essential element in fibrinolytic process, and is synthesized primarily liver. activation occurs through action of plasminogen activator, converting it into plasmin. This conversion greatly enhances system within tissues blood vessels, facilitating dissolution fibrin clots. Consequently, congenital deficiency results impaired degradation. Patients with typically exhibit deposits various mucosal sites throughout body, including oral cavity, eyes, vagina, digestive organs. Behcet's disease a chronic recurrent systemic inflammatory four main symptoms: aphthous ulcers mucosa, vulvar ulcers, skin symptoms, eye has been reported worldwide. highly prevalent around Silk Road from Mediterranean East Asia. We report case periodontitis patient these two rare diseases that worsened quickly, leading alveolar bone destruction. Genetic testing revealed novel variant characterized by stop-gain mutation, which may be previously unidentified etiologic gene associated decreased activity.This depicts diagnosed ligneous gingivitis during childhood, originating progressing periodontitis. suspected association PLG c.1468C > T (p.Arg490*) mutation. The patient's periodontal condition remained stable brief intervals supportive therapy. However, emergence Behçet's induced acute inflammation, necessitating hospitalization treatment steroids. During hospitalization, dental approach focused on maintaining hygiene alleviating contact-related pain. overall health improved inpatient care deteriorated.Collaborative efforts between medical professionals are paramount comprehensively evaluating treating patients intricate complications diseases. Furthermore, mutation could contribute related conditions.

Язык: Английский

Процитировано

1

Local periodontal immune status of patients after new coronavirus infection DOI
З. Ф. Хараева,

D. A. Elgarova,

I. S. Khagabanova

и другие.

Medical alphabet, Год журнала: 2024, Номер 34, С. 39 - 43

Опубликована: Янв. 18, 2024

The aim of the study was to identify indicators cytokine and free radical periodontal status patients with moderate severity periodontitis that occurred after a new coronavirus infection 1–3 monthes ago. IL‑1ß, IL‑6, IL‑10, IL‑17A, nitrate-nitrite concentration, antioxidant activity, matrix metalloproteinase MMP‑8 in gingival fluid samples were studied. A significant increase local level methylproteinase‑8 nitrate-nitrites found compared diseases same severity, who have not had covid (p < 0.05). Patients undergoing develop comprehensive methods therapy prevention complications.

Язык: Английский

Процитировано

0

Comorbidity of periodontal diseases and atopic dermatitis DOI Open Access
O. S. Donskaya, Ekaterina I. Berdnikova

Russian Journal of Dentistry, Год журнала: 2024, Номер 28(2), С. 181 - 190

Опубликована: Март 29, 2024

BACKGROUND: The relationship between periodontal diseases and somatic pathology has been proven. Studies on the link atopic are few, which determines relevance of this study. AIM: To characterize inflammatory dermatitis. MATERIALS AND METHODS: Overall, 26,470 full-text publications from 2016 to 2023 research topic were found in databases PubMed, Google Scholar, eLIBRARY.RU. RESULTS: An analysis literature data was performed study On one hand, presence oral patients with can lead disease worsening, other an contribute development diseases. After conducting a search applying inclusion exclusion criteria for sample, complete overlap topics three publications. obtained contradictory, as two established direct connection periodontitis dermatitis publication did not. In studies certain aspects, possible mechanisms comorbidity characterized assessments existence feedback or these pathologies presented. CONCLUSION: status remains poorly understood, evidence linking it is ambiguous. presented relatively confirmed dermatitis; however, hygiene hypothesis, that is, there inverse diseases, not confirmed.

Язык: Английский

Процитировано

0

Comorbidity of rheumatoid arthritis and periodontal diseases DOI Creative Commons
Д. И. Трухан,

Anatoly F. Sulimov,

L. Yu. Trukhan

и другие.

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 5, С. 288 - 297

Опубликована: Май 13, 2024

A growing body of evidence suggests that periodontal pathology, accompanied by oral inflammation and pathological changes in the microbiome, induces gut microbiome (oral-gut axis) is involved pathogenesis systemic diseases. This review focuses on published literature, with an emphasis last decade, assessing whether disease, primarily periodontitis, periodontopathic bacteria are risk factors for development rheumatoid arthritis. The examines bilateral connections between arthritis highlights main links this connection. Porphyromonas gingivalis other may contribute to inflammatory diseases remodeling normally benign microbiota into a dysbiotic one. expresses endogenous citrullinated proteins its own unique bacterial enzyme, peptidyl arginine deminase, leading formation cyclic peptide autoantibodies impaired immunotolerance susceptible patients. Results from clinical studies suggest people periodontitis infection at developing arthritis, supporting findings experimental studies. Non-surgical treatment likely effective controlling reducing disease activity (primarily DAS28 ESR). These observations highlight importance health need prevention early patients

Язык: Английский

Процитировано

0