Local periodontal immune status of patients after new coronavirus infection

Medical alphabet, Journal Year: 2024, Volume and Issue: 34, P. 39 - 43

Published: Jan. 18, 2024

The aim of the study was to identify indicators cytokine and free radical periodontal status patients with moderate severity periodontitis that occurred after a new coronavirus infection 1–3 monthes ago. IL‑1ß, IL‑6, IL‑10, IL‑17A, nitrate-nitrite concentration, antioxidant activity, matrix metalloproteinase MMP‑8 in gingival fluid samples were studied. A significant increase local level methylproteinase‑8 nitrate-nitrites found compared diseases same severity, who have not had covid (p < 0.05). Patients undergoing develop comprehensive methods therapy prevention complications.

Language: Английский

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Comorbidity of periodontal diseases and atopic dermatitis

Russian Journal of Dentistry, Journal Year: 2024, Volume and Issue: 28(2), P. 181 - 190

Published: March 29, 2024

BACKGROUND: The relationship between periodontal diseases and somatic pathology has been proven. Studies on the link atopic are few, which determines relevance of this study. AIM: To characterize inflammatory dermatitis. MATERIALS AND METHODS: Overall, 26,470 full-text publications from 2016 to 2023 research topic were found in databases PubMed, Google Scholar, eLIBRARY.RU. RESULTS: An analysis literature data was performed study On one hand, presence oral patients with can lead disease worsening, other an contribute development diseases. After conducting a search applying inclusion exclusion criteria for sample, complete overlap topics three publications. obtained contradictory, as two established direct connection periodontitis dermatitis publication did not. In studies certain aspects, possible mechanisms comorbidity characterized assessments existence feedback or these pathologies presented. CONCLUSION: status remains poorly understood, evidence linking it is ambiguous. presented relatively confirmed dermatitis; however, hygiene hypothesis, that is, there inverse diseases, not confirmed.

Language: Английский

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Comorbidity of rheumatoid arthritis and periodontal diseases

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 5, P. 288 - 297

Published: May 13, 2024

A growing body of evidence suggests that periodontal pathology, accompanied by oral inflammation and pathological changes in the microbiome, induces gut microbiome (oral-gut axis) is involved pathogenesis systemic diseases. This review focuses on published literature, with an emphasis last decade, assessing whether disease, primarily periodontitis, periodontopathic bacteria are risk factors for development rheumatoid arthritis. The examines bilateral connections between arthritis highlights main links this connection. Porphyromonas gingivalis other may contribute to inflammatory diseases remodeling normally benign microbiota into a dysbiotic one. expresses endogenous citrullinated proteins its own unique bacterial enzyme, peptidyl arginine deminase, leading formation cyclic peptide autoantibodies impaired immunotolerance susceptible patients. Results from clinical studies suggest people periodontitis infection at developing arthritis, supporting findings experimental studies. Non-surgical treatment likely effective controlling reducing disease activity (primarily DAS28 ESR). These observations highlight importance health need prevention early patients

Language: Английский

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Exploring the Bidirectional Relationship Between Periodontitis and Rheumatoid Arthritis in a Large Danish Cohort

ACR Open Rheumatology, Journal Year: 2024, Volume and Issue: 6(9), P. 598 - 608

Published: July 5, 2024

We investigated the bidirectional relationship between rheumatoid arthritis (RA) and periodontitis their cross-sectional association using national administrative health care data.

Language: Английский

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The Molecular Comorbidity Network of Periodontal Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10161 - 10161

Published: Sept. 21, 2024

Periodontal disease, a multifactorial inflammatory condition affecting the supporting structures of teeth, has been increasingly recognized for its association with various systemic diseases. Understanding molecular comorbidities periodontal disease is crucial elucidating shared pathogenic mechanisms and potential therapeutic targets. In this study, we conducted comprehensive literature biological database mining by utilizing DisGeNET2R extracting gene–disease associations, Romin integrating modeling interaction networks, Rentrez R libraries accessing retrieving relevant information from NCBI databases. This integrative bioinformatics approach enabled us to systematically identify diseases sharing associated genes, proteins, or pathways periodontitis. Our analysis revealed significant overlaps between several conditions, including cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, bowel Shared implicated in pathogenesis these periodontitis encompassed dysregulation mediators, immune response pathways, oxidative stress alterations extracellular matrix. Furthermore, network unveiled key hub genes proteins (such as TNF, IL6, PTGS2, IL10, NOS3, IL1B, VEGFA, BCL2, STAT3, LEP TP53) that play pivotal roles crosstalk comorbidities, offering targets intervention. Insights gained shed light on intricate interplay health well-being, emphasizing importance interdisciplinary collaboration developing personalized treatment strategies patients comorbidities.

Language: Английский

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