Low‐Speed Platelet‐Rich Fibrin Membrane in Conjunction With Demineralized Freeze‐Dried Bone Allograft (DFDBA) Compared to Collagen Membrane With DFDBA in Noncontained Intraosseous Defects of Stage III Periodontitis: A Randomized Controlled Clinical Trial
International Journal of Dentistry,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Aim:
Noncontained
(1‐
or
combined
1‐
to
2‐wall)
periodontal
intraosseous
defects
represent
challenging
clinical
situations
with
unpredictable
surgical
therapeutic
outcomes.
This
randomized
trial
assessed
demineralized
freeze‐dried
bone
allograft
(DFDBA)
low
speed‐platelet‐rich
fibrin
(PRF)
membrane
compared
DFDBA
collagen
(CM)
in
the
therapy
of
noncontained
stage
III
periodontitis
patients.
Methodology:
Twenty‐two
patients
measuring
≥3
mm
and
attachment
loss
≥5
were
randomly
allocated
into
two
groups:
test
group
(low‐speed
PRF
+
DFDBA)
control
(CM
DFDBA),
11
participants
per
group.
Clinical
radiographic
assessments
conducted
at
baseline,
3,
6,
9,
12
months
for
level
(CAL;
primary
outcome),
gingival
recession
depth
(GRD),
probing
(PD),
full
mouth
bleeding
score
(FMBS)
plaque
(FMPS),
fill
linear
defect
(RLDD;
all
secondary
outcomes).
Results:
The
mean
(±SD)
CAL‐gain
was
2.45
(±1.51),
2.91
(±1.70),
(±1.87),
2.82
(±1.83)
mm,
while
(±1.25),
3.27
(±1.27),
3.00
(±1.41),
2.64
(±1.50)
months,
respectively,
no
significant
intergroup
differences
(
p
>
0.05).
Despite
absence
differences,
both
groups
demonstrated
intragroup
improvement
CAL‐
PD‐gain,
RLDD‐reduction
as
well
RLDD
<
Conclusion:
membranes,
conjunction
DFDBA,
show
parameters,
comparable
CMs
DFDBA.
Trial
Registration:
ClinicalTrials.gov
identifier:
NCT03922503
Язык: Английский
COMPARISON OF TECHNIQUES FOR THE SURGICAL STAGE OF SIMULTANEOUS AND DELAYED DENTAL IMPLANTATION (LITERATURE REVIEW)
Bulletin of Problems Biology and Medicine,
Год журнала:
2025,
Номер
1(1), С. 91 - 91
Опубликована: Янв. 1, 2025
Язык: Английский
Applications of Growth Factors in Implant Dentistry
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(5), С. 317 - 317
Опубликована: Апрель 28, 2025
Growth
factors
are
proteins
that
play
an
essential
part
in
tissue
regeneration
and
development.
They
attach
surface
receptors
to
mediate
their
actions
on
cells.
Signaling
systems
within
cells
activated
when
growth
bind
associated
receptors.
These
signaling
cascades
control
the
transcription
of
genes
involved
cellular
functions
like
proliferation,
differentiation,
migration,
protein
synthesis,
metabolism.
This
narrative
review
provides
a
comprehensive
update
use
implant
dentistry
with
special
emphasis
human
clinical
trials.
Since
wound
healing
osseointegration
pre-requisites
successful
implantation
important
components
homeostasis
healing,
this
first
starts
basic
biology
healing.
Then,
it
presents
specific
role
regeneration.
Finally,
PubMed
database
was
searched
using
relevant
keywords
some
filters
related
research
question.
Out
initial
44
records,
all
studies
(n
=
29)
actual
dental
placement
its
assessment
were
included.
results
published
literature
over
last
25
years
different
applications
field
critically
discussed.
Язык: Английский
Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial
BMC Oral Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Май 23, 2025
Injectable
platelet-rich
fibrin
(I-PRF)
is
an
autologous
matrix
rich
in
leucocytes,
platelets
and
growth
factors,
could
serve
as
a
sustained-release
vehicle
for
variety
of
active
biomolecules.
The
aim
the
current
randomized
controlled
trial
was
to
compare
effect
vitamin
C
(VitC)
with
I-PRF
locally
delivered
adjunct
professional
mechanical
plaque
removal
(PMPR)
versus
PMPR
local
delivery
or
alone
on
non-surgical
periodontal
treatment
(NSPT)
outcomes
stage-II
periodontitis.
Forty-five
patients
(n
=
45)
diagnosed
grade
A
periodontitis
were
randomly
assigned
into
test
(PMPR
+
I-PRF/VitC;
n
15)
control
groups
I-PRF;
15
PMPR;
15).
Bleeding
probing
(BOP;
primary
outcome),
depth
(PD),
clinical
attachment
level
(CAL),
gingival
margin
(GM),
index
(PI)
radiographic
bone
gain/loss
(horizontal,
vertical
total)
assessed
at
baseline,
three-
six-months
post-treatment.
Post-operative
pain
further
second-
third-day
Although
BOP
scores
lower
I-PRF/VitC
group,
regression
analysis
revealed
that
gender
only
significant
predictor
BOP,
females
showing
reduced
propensity
(p
<
0.05).
Clinical
parameters
significantly
improved
all
independently
PD-reduction
1.73
±
0.59
mm,
1.67
0.49
mm
CAL-change
1.33
1.20
0.56
0.93
GM-change
0.40
0.51
0.33
0.73
0.70
I-PRF/VitC,
respectively.
No
intergroup
differences
notable
regarding
changes
PD,
CAL,
GM,
PI
measurements
three
six
months
relative
baseline
>
Significantly
two
days
compared
group
Apart
from
positive
patients'
post
operative
perception,
without
addition
does
not
additionally
improve
NSPT
patients.
Trial
registration.
study
retrospectively
registered
US
National
Institutes
Health
Trials
Registry
(NCT05129267)
2021-11-10.
Язык: Английский