Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial DOI Creative Commons
Mohamed H. Sherif,

Enas Anter,

Christian Graetz

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 23, 2025

Injectable platelet-rich fibrin (I-PRF) is an autologous matrix rich in leucocytes, platelets and growth factors, could serve as a sustained-release vehicle for variety of active biomolecules. The aim the current randomized controlled trial was to compare effect vitamin C (VitC) with I-PRF locally delivered adjunct professional mechanical plaque removal (PMPR) versus PMPR local delivery or alone on non-surgical periodontal treatment (NSPT) outcomes stage-II periodontitis. Forty-five patients (n = 45) diagnosed grade A periodontitis were randomly assigned into test (PMPR + I-PRF/VitC; n 15) control groups I-PRF; 15 PMPR; 15). Bleeding probing (BOP; primary outcome), depth (PD), clinical attachment level (CAL), gingival margin (GM), index (PI) radiographic bone gain/loss (horizontal, vertical total) assessed at baseline, three- six-months post-treatment. Post-operative pain further second- third-day Although BOP scores lower I-PRF/VitC group, regression analysis revealed that gender only significant predictor BOP, females showing reduced propensity (p < 0.05). Clinical parameters significantly improved all independently PD-reduction 1.73 ± 0.59 mm, 1.67 0.49 mm CAL-change 1.33 1.20 0.56 0.93 GM-change 0.40 0.51 0.33 0.73 0.70 I-PRF/VitC, respectively. No intergroup differences notable regarding changes PD, CAL, GM, PI measurements three six months relative baseline > Significantly two days compared group Apart from positive patients' post operative perception, without addition does not additionally improve NSPT patients. Trial registration. study retrospectively registered US National Institutes Health Trials Registry (NCT05129267) 2021-11-10.

Language: Английский

Low‐Speed Platelet‐Rich Fibrin Membrane in Conjunction With Demineralized Freeze‐Dried Bone Allograft (DFDBA) Compared to Collagen Membrane With DFDBA in Noncontained Intraosseous Defects of Stage III Periodontitis: A Randomized Controlled Clinical Trial DOI Creative Commons
Najeeb Almoliky, Manal Hosny, Weam Elbattawy

et al.

International Journal of Dentistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Aim: Noncontained (1‐ or combined 1‐ to 2‐wall) periodontal intraosseous defects represent challenging clinical situations with unpredictable surgical therapeutic outcomes. This randomized trial assessed demineralized freeze‐dried bone allograft (DFDBA) low speed‐platelet‐rich fibrin (PRF) membrane compared DFDBA collagen (CM) in the therapy of noncontained stage III periodontitis patients. Methodology: Twenty‐two patients measuring ≥3 mm and attachment loss ≥5 were randomly allocated into two groups: test group (low‐speed PRF + DFDBA) control (CM DFDBA), 11 participants per group. Clinical radiographic assessments conducted at baseline, 3, 6, 9, 12 months for level (CAL; primary outcome), gingival recession depth (GRD), probing (PD), full mouth bleeding score (FMBS) plaque (FMPS), fill linear defect (RLDD; all secondary outcomes). Results: The mean (±SD) CAL‐gain was 2.45 (±1.51), 2.91 (±1.70), (±1.87), 2.82 (±1.83) mm, while (±1.25), 3.27 (±1.27), 3.00 (±1.41), 2.64 (±1.50) months, respectively, no significant intergroup differences ( p > 0.05). Despite absence differences, both groups demonstrated intragroup improvement CAL‐ PD‐gain, RLDD‐reduction as well RLDD < Conclusion: membranes, conjunction DFDBA, show parameters, comparable CMs DFDBA. Trial Registration: ClinicalTrials.gov identifier: NCT03922503

Language: Английский

Citations

1
COMPARISON OF TECHNIQUES FOR THE SURGICAL STAGE OF SIMULTANEOUS AND DELAYED DENTAL IMPLANTATION (LITERATURE REVIEW) DOI Creative Commons

V. V. Chemerys

Bulletin of Problems Biology and Medicine, Journal Year: 2025, Volume and Issue: 1(1), P. 91 - 91

Published: Jan. 1, 2025

Language: Английский

Citations

0
Applications of Growth Factors in Implant Dentistry DOI Creative Commons

Balen Hamid Qadir,

Mohammed Aso Abdulghafor,

Mohammed Khalid Mahmood

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 317 - 317

Published: April 28, 2025

Growth factors are proteins that play an essential part in tissue regeneration and development. They attach surface receptors to mediate their actions on cells. Signaling systems within cells activated when growth bind associated receptors. These signaling cascades control the transcription of genes involved cellular functions like proliferation, differentiation, migration, protein synthesis, metabolism. This narrative review provides a comprehensive update use implant dentistry with special emphasis human clinical trials. Since wound healing osseointegration pre-requisites successful implantation important components homeostasis healing, this first starts basic biology healing. Then, it presents specific role regeneration. Finally, PubMed database was searched using relevant keywords some filters related research question. Out initial 44 records, all studies (n = 29) actual dental placement its assessment were included. results published literature over last 25 years different applications field critically discussed.

Language: Английский

Citations

0
Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial DOI Creative Commons
Mohamed H. Sherif,

Enas Anter,

Christian Graetz

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 23, 2025

Injectable platelet-rich fibrin (I-PRF) is an autologous matrix rich in leucocytes, platelets and growth factors, could serve as a sustained-release vehicle for variety of active biomolecules. The aim the current randomized controlled trial was to compare effect vitamin C (VitC) with I-PRF locally delivered adjunct professional mechanical plaque removal (PMPR) versus PMPR local delivery or alone on non-surgical periodontal treatment (NSPT) outcomes stage-II periodontitis. Forty-five patients (n = 45) diagnosed grade A periodontitis were randomly assigned into test (PMPR + I-PRF/VitC; n 15) control groups I-PRF; 15 PMPR; 15). Bleeding probing (BOP; primary outcome), depth (PD), clinical attachment level (CAL), gingival margin (GM), index (PI) radiographic bone gain/loss (horizontal, vertical total) assessed at baseline, three- six-months post-treatment. Post-operative pain further second- third-day Although BOP scores lower I-PRF/VitC group, regression analysis revealed that gender only significant predictor BOP, females showing reduced propensity (p < 0.05). Clinical parameters significantly improved all independently PD-reduction 1.73 ± 0.59 mm, 1.67 0.49 mm CAL-change 1.33 1.20 0.56 0.93 GM-change 0.40 0.51 0.33 0.73 0.70 I-PRF/VitC, respectively. No intergroup differences notable regarding changes PD, CAL, GM, PI measurements three six months relative baseline > Significantly two days compared group Apart from positive patients' post operative perception, without addition does not additionally improve NSPT patients. Trial registration. study retrospectively registered US National Institutes Health Trials Registry (NCT05129267) 2021-11-10.

Language: Английский

Citations

0