Maternal Oxidative Stress Throughout Pregnancy and Early Childhood Neurodevelopment at Different Stages: Insights from a Prospective Cohort Study DOI
Sen He, Jingyu Wang,

Shuting Cao

и другие.

Опубликована: Янв. 1, 2025

Abstract Background: Maternal oxidative stress during pregnancy plays as hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal biomarkers across and neurodevelopmental outcomes different stages early childhood. Methods: This is a cohort study conducted 1791 mother-child pairs from Wuhan, China. Three biomarkers, including DNA biomarker (8-hydroxy-2'-deoxyguanosine, 8-OHdG), RNA (8-hydroxyguanosine, 8-OHG), lipid (4-hydroxy nonenal mercapturic acid, HNE-MA), were measured repeatedly collected urine samples three trimesters pregnancy. We followed children at age 2, 3, 4-6 years. At Bayley Scales was employed assess children's mental psychomotor development. Brain-derived neurotrophic (BDNF) levels plasma 3. The Wechsler Preschool Primary Scale - Fourth Edition (WPPSI-IV) used intelligence quotients ages 4-6. Generalized estimating equations performed explore outcomes. Results: Higher HNE-MA late-pregnancy associated with lower development index 2 (β: -0.95; 95% CI: -1.78∼ -0.11). Elevated early- mid-pregnancy decreased BDNF 3 -0.07; -0.13∼ -0.01). Each unit increase natural log-transformed (Ln) 8-OHdG 8-OHG concentrations decrease full-scale quotient 5.94 years -1.55 points (95% -2.84 ∼ -0.26) -1.89 -3.30 -0.49), respectively. Conclusion: suggested that higher each trimester might be risk consistently suboptimal childhood, pre-school ages.

Язык: Английский

Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases DOI Creative Commons

Zhenlei Chen,

Ziqi Yuan,

Shangchen Yang

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2022, Номер 29(1), С. 24 - 36

Опубликована: Окт. 3, 2022

Abstract Astrocytes are the most abundant cells in brain. They have many important functions central nervous system (CNS), including maintenance of glutamate and ion homeostasis, elimination oxidative stress, energy storage glycogen, tissue repair, regulating synaptic activity by releasing neurotransmitters, participating formation. special highly ramified structure. Their branches contact with synapses neurons inwardly, fine structure wrapping synapses; their feet blood vessels brain parenchyma outward, almost whole The adjacent astrocytes rarely overlap communicate each other through gap junction channels. ideal location enables them to sense weak changes surroundings provide structural basis for supply neurons. Neurons closely coupled units metabolism consume a lot ATPs process neurotransmission. metabolic substrates neurons, maintain high neuron, facilitate information transmission This article reviews characteristics glucose metabolism, lipid amino acid astrocytes. interactions between microglia were also detailed discussed. Finally, we classified analyzed role disorder occurrence development neurodegenerative diseases.

Язык: Английский

Процитировано

78
Mitochondria-Targeted Antioxidants, an Innovative Class of Antioxidant Compounds for Neurodegenerative Diseases: Perspectives and Limitations DOI Open Access
Matteo Fields, Annalisa Marcuzzi, Arianna Gonelli

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3739 - 3739

Опубликована: Фев. 13, 2023

Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by progressive loss neuronal functions and structures. Despite having different genetic backgrounds etiology, in recent years, many studies have highlighted point convergence the mechanisms leading to neurodegeneration: mitochondrial dysfunction oxidative stress been observed pathologies, their detrimental effects on neurons contribute exacerbation pathological phenotype at various degrees. In this context, increasing relevance has acquired antioxidant therapies, with purpose restoring order revert damage. However, conventional antioxidants were not able specifically accumulate diseased mitochondria, often eliciting harmful whole body. last decades, novel, precise, mitochondria-targeted (MTA) compounds developed studied, both vitro vivo, address need counter mitochondria restore energy supply membrane potentials neurons. review, we focus activity therapeutic perspectives MitoQ, SkQ1, MitoVitE MitoTEMPO, most studied belonging class MTA conjugated lipophilic cations, reach compartment.

Язык: Английский

Процитировано

45
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases DOI Creative Commons
Sen Yang, Jung Hyun Park, Hui‐Chen Lu

и другие.

Molecular Neurodegeneration, Год журнала: 2023, Номер 18(1)

Опубликована: Июль 20, 2023

Abstract Human studies consistently identify bioenergetic maladaptations in brains upon aging and neurodegenerative disorders of (NDAs), such as Alzheimer’s disease, Parkinson’s Huntington’s Amyotrophic lateral sclerosis. Glucose is the major brain fuel glucose hypometabolism has been observed regions vulnerable to NDAs. Many susceptible are topological central hub connectome, linked by densely interconnected long-range axons. Axons, key components have high metabolic needs support neurotransmission other essential activities. Long-range axons particularly injury, neurotoxin exposure, protein stress, lysosomal dysfunction, etc. Axonopathy often an early sign neurodegeneration. Recent ascribe axonal maintenance failures local dysregulation. With this review, we aim stimulate research exploring metabolically oriented neuroprotection strategies enhance or normalize bioenergetics NDA models. Here start summarizing evidence from human patients animal models reveal correlation between connectomic disintegration aging/NDAs. To encourage mechanistic investigations on how dysregulation occurs during aging/NDAs, first review current literature distinct subdomains: axon initial segments, myelinated arbors harboring pre-synaptic boutons. In each subdomain, focus organization, activity-dependent regulation system, external glial support. Second, mechanisms regulating nicotinamide adenine dinucleotide (NAD + ) homeostasis, molecule for energy metabolism processes, including NAD biosynthetic, recycling, consuming pathways. Third, highlight innate vulnerability connectome discuss its perturbation As deficits developing into NDAs, especially asymptomatic phase, they likely exaggerated further impaired energetic cost neural network hyperactivity, pathology. Future interrogating causal relationship vulnerability, axonopathy, amyloid/tau pathology, cognitive decline will provide fundamental knowledge therapeutic interventions.

Язык: Английский

Процитировано

43
Lipid Droplets and Neurodegeneration DOI
Keya Mallick,

Shuchismita Paul,

Sayani Banerjee

и другие.

Neuroscience, Год журнала: 2024, Номер 549, С. 13 - 23

Опубликована: Май 6, 2024

Язык: Английский

Процитировано

15
The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions DOI Creative Commons
Joern R. Steinert, Haitham Amal

Free Radical Biology and Medicine, Год журнала: 2022, Номер 194, С. 71 - 83

Опубликована: Ноя. 24, 2022

Язык: Английский

Процитировано

39
MicroRNA (miRNA) as a biomarker for diagnosis, prognosis, and therapeutics molecules in neurodegenerative disease DOI Open Access

Zahraa Alkhazaali-Ali,

Sajad Sahab-Negah,

Amir Reza Boroumand

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116899 - 116899

Опубликована: Июнь 17, 2024

Neurodegenerative diseases that include Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD), Huntington's (HD), and multiple (MS) arise due to numerous causes like protein accumulation autoimmunity characterized by neurologic depletion which lead incapacity in normal physiological function such as thinking movement these patients. Glial cells perform an important role protective neuronal function; the case of neuroinflammation, glial cell dysfunction can promote development neurodegenerative diseases. miRNA participates gene regulation plays a vital many biological processes body; central nervous system (CNS), it play essential part neural maturation differentiation. In diseases, dysregulation occurs, enhancing this review, we discuss (Alzheimer's (MS)) how is preserved diagnostic biomarker or therapeutic agent disorders. Finally, highlight therapy.

Язык: Английский

Процитировано

13
Gut microbes in central nervous system development and related disorders DOI Creative Commons

Yumeng Gan,

Yao Chen,

Huijie Zhong

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 26, 2024

The association between gut microbiota and central nervous system (CNS) development has garnered significant research attention in recent years. Evidence suggests bidirectional communication the CNS through brain-gut axis. As a long complex process, is highly susceptible to both endogenous exogenous factors. impacts by regulating neurogenesis, myelination, glial cell function, synaptic pruning, blood-brain barrier permeability, with implication various disorders. This review outlines relationship stages of (prenatal postnatal), emphasizing integral role microbes. Furthermore, explores implications neurodevelopmental disorders, such as autism spectrum disorder, Rett syndrome, Angelman offering insights into early detection, prompt intervention, innovative treatments.

Язык: Английский

Процитировано

10
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products DOI
Kailin Yang,

Liuting Zeng,

Jinsong Zeng

и другие.

Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102063 - 102063

Опубликована: Сен. 9, 2023

Язык: Английский

Процитировано

17
Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes DOI Creative Commons
Zihan Li, Yayi Jiang,

Caiyi Long

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Metabolic syndrome (MetS) and cognitive dysfunction pose significant challenges to global health the economy. Systemic inflammation, endocrine disruption, autoregulatory impairment drive neurodegeneration microcirculatory damage in MetS. Due their unique anatomy function, astrocytes sense integrate multiple metabolic signals, including peripheral hormones nutrients. Astrocytes synapses engage a complex dialogue of energetic immunological interactions. act as bridge between MetS dysfunction, undergoing diverse activation response dysfunction. This article summarizes alterations astrocyte phenotypic characteristics across pathological factors It also discusses clinical value critical pathologic diagnostic marker potential therapeutic target for MetS-associated

Язык: Английский

Процитировано

6
The Role of Acyl-CoA β-Oxidation in Brain Metabolism and Neurodegenerative Diseases DOI Open Access
Sylwia Szrok-Jurga, Jacek Turyn, Areta Hebanowska

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 13977 - 13977

Опубликована: Сен. 12, 2023

This review highlights the complex role of fatty acid β-oxidation in brain metabolism. It demonstrates fundamental importance degradation as a fuel energy balance and an essential component lipid homeostasis, aging, neurodegenerative disorders.

Язык: Английский

Процитировано

15