Maternal Oxidative Stress Throughout Pregnancy and Early Childhood Neurodevelopment at Different Stages: Insights from a Prospective Cohort Study DOI
Sen He, Jingyu Wang,

Shuting Cao

и другие.

Опубликована: Янв. 1, 2025

Abstract Background: Maternal oxidative stress during pregnancy plays as hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal biomarkers across and neurodevelopmental outcomes different stages early childhood. Methods: This is a cohort study conducted 1791 mother-child pairs from Wuhan, China. Three biomarkers, including DNA biomarker (8-hydroxy-2'-deoxyguanosine, 8-OHdG), RNA (8-hydroxyguanosine, 8-OHG), lipid (4-hydroxy nonenal mercapturic acid, HNE-MA), were measured repeatedly collected urine samples three trimesters pregnancy. We followed children at age 2, 3, 4-6 years. At Bayley Scales was employed assess children's mental psychomotor development. Brain-derived neurotrophic (BDNF) levels plasma 3. The Wechsler Preschool Primary Scale - Fourth Edition (WPPSI-IV) used intelligence quotients ages 4-6. Generalized estimating equations performed explore outcomes. Results: Higher HNE-MA late-pregnancy associated with lower development index 2 (β: -0.95; 95% CI: -1.78∼ -0.11). Elevated early- mid-pregnancy decreased BDNF 3 -0.07; -0.13∼ -0.01). Each unit increase natural log-transformed (Ln) 8-OHdG 8-OHG concentrations decrease full-scale quotient 5.94 years -1.55 points (95% -2.84 ∼ -0.26) -1.89 -3.30 -0.49), respectively. Conclusion: suggested that higher each trimester might be risk consistently suboptimal childhood, pre-school ages.

Язык: Английский

Caspase‐1/11 controls Zika virus replication in astrocytes by inhibiting glycolytic metabolism DOI Open Access
Ingrid Sancho de Farias, Guilherme Ribeiro, Isaú H. Noronha

и другие.

FEBS Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Zika virus (ZIKV) poses a significant threat due to its association with severe neurological complications, particularly during pregnancy. Although viruses exhibit tropism for neural cells, including astrocytes, the role of these cells in controlling ZIKV replication remains unclear. In this study, we demonstrated that induces caspase‐1 activation primary astrocytes despite absence classical signs inflammasome activation. Caspase‐1 and caspase‐11 double knockout ( caspase‐1/11 −/− ) heightened permissiveness viral replication, accompanied by overactivation glycolytic metabolism. Inhibition glycolysis reversed susceptibility infection. Protein network analysis revealed mammalian target rapamycin complex (mTORC) as link between proteins involved caspase‐1, mTORC inhibition also suppressed replication. Furthermore, found impact on depends regulation pyruvate transport mitochondria Overall, our findings elucidate caspase‐1/11‐dependent microbicidal mechanism involves mTORC/glycolytic pathway/pyruvate axis, providing insights into potential therapeutic targets

Язык: Английский

Процитировано

0
The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression DOI Creative Commons
Cong He, Baojiang Chen,

Hecai Yang

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Март 27, 2025

Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.

Язык: Английский

Процитировано

0
Systematic review of 31P-magnetic resonance spectroscopy studies of brain high energy phosphates and membrane phospholipids in aging and Alzheimer's disease DOI Creative Commons

Steven Jett,

Camila Boneu,

Camila Zarate

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Май 18, 2023

Many lines of evidence suggest that mitochondria have a central role in aging-related neurodegenerative diseases, such as Alzheimer's disease (AD). Mitochondrial dysfunction, cerebral energy dysmetabolism and oxidative damage increase with age, are early event AD pathophysiology may precede amyloid beta (Aβ) plaques. In vivo probes mitochondrial function metabolism therefore crucial to characterize the bioenergetic abnormalities underlying risk, their relationship cognition. A majority research conducted humans used 18 F-fluoro-deoxygluose (FDG) PET image glucose (CMRglc), but key information regarding phosphorylation (OXPHOS), process which generates 90% for brain, cannot be assessed this method. Thus, there is need imaging tools measure processes OXPHOS human brain. 31 Phosphorus-magnetic resonance spectroscopy ( P-MRS) non-invasive method allows measurement OXPHOS-related high-energy phosphates (HEP), including phosphocreatine (PCr), adenosine triphosphate (ATP), inorganic phosphate (Pi), addition potential hydrogen (pH), well components phospholipid metabolism, phosphomonoesters (PMEs) phosphodiesters (PDEs). Herein, we provide systematic review existing literature utilizing P-MRS methodology during normal aging patients mild cognitive impairment (MCI) AD, an additional focus on individuals at risk AD. We discuss strengths limitations technique, considering future directions toward validating use measures biomarkers detection

Язык: Английский

Процитировано

12
The effects of vitamin D on different types of cells DOI

Mária Janubová,

Ingrid Žitňanová

Steroids, Год журнала: 2023, Номер 202, С. 109350 - 109350

Опубликована: Дек. 12, 2023

Язык: Английский

Процитировано

11
Maternal Oxidative Stress Throughout Pregnancy and Early Childhood Neurodevelopment at Different Stages: Insights from a Prospective Cohort Study DOI
Sen He, Jingyu Wang,

Shuting Cao

и другие.

Опубликована: Янв. 1, 2025

Abstract Background: Maternal oxidative stress during pregnancy plays as hazardous factor of offspring neurodevelopment in animal models. However, epidemiological evidence remains limited. In this prospective cohort, we aimed to investigate the associations between maternal biomarkers across and neurodevelopmental outcomes different stages early childhood. Methods: This is a cohort study conducted 1791 mother-child pairs from Wuhan, China. Three biomarkers, including DNA biomarker (8-hydroxy-2'-deoxyguanosine, 8-OHdG), RNA (8-hydroxyguanosine, 8-OHG), lipid (4-hydroxy nonenal mercapturic acid, HNE-MA), were measured repeatedly collected urine samples three trimesters pregnancy. We followed children at age 2, 3, 4-6 years. At Bayley Scales was employed assess children's mental psychomotor development. Brain-derived neurotrophic (BDNF) levels plasma 3. The Wechsler Preschool Primary Scale - Fourth Edition (WPPSI-IV) used intelligence quotients ages 4-6. Generalized estimating equations performed explore outcomes. Results: Higher HNE-MA late-pregnancy associated with lower development index 2 (β: -0.95; 95% CI: -1.78∼ -0.11). Elevated early- mid-pregnancy decreased BDNF 3 -0.07; -0.13∼ -0.01). Each unit increase natural log-transformed (Ln) 8-OHdG 8-OHG concentrations decrease full-scale quotient 5.94 years -1.55 points (95% -2.84 ∼ -0.26) -1.89 -3.30 -0.49), respectively. Conclusion: suggested that higher each trimester might be risk consistently suboptimal childhood, pre-school ages.

Язык: Английский

Процитировано

0