Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer DOI Creative Commons
Yun Wei, Xiaofei Du, Hongling Guo

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Дек. 17, 2024

In recent years, mitochondrial transfer has emerged as a universal phenomenon intertwined with various systemic physiological and pathological processes. Alzheimer's disease (AD) is multifactorial disease, dysfunction at its core. Although numerous studies have found evidence of in AD models, the precise mechanisms remain unclear. Recent revealed dynamic mitochondria not only between nerve cells glial cells, but also cells. this review, we explore pathways how these activities contribute to progression.

Язык: Английский

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology DOI Creative Commons

E. N. Fedorova,

А. В. Егорова, Д. Н. Воронков

и другие.

Journal of Molecular Pathology, Год журнала: 2023, Номер 4(4), С. 333 - 348

Опубликована: Дек. 9, 2023

The following review considers current concepts concerning the characteristics of DRP1-related mitochondrial division in brain cells during hypoxic-ischemic pathology. functional role DRP1 neurons and astroglia cerebral ischemia conditions was analyzed. We discuss potential for regulating activity through selective inhibitor fission, mdivi-1. article also presents data on involvement astro- microglia-mediated intercellular transport. Understanding molecular mechanisms responsible fission exposure will allow us to consider as an effective therapeutic target treating with a hypoxic component.

Язык: Английский

Процитировано

1

ER-organelle contacts: A signaling hub for neurological diseases DOI Creative Commons
Yunli Wang, Jinghua Yang

Pharmacological Research, Год журнала: 2024, Номер 203, С. 107149 - 107149

Опубликована: Март 20, 2024

Neuronal health is closely linked to the homeostasis of intracellular organelles, and organelle dysfunction affects pathological progression neurological diseases. In contrast isolated cellular compartments, a growing number studies have found that organelles are largely interdependent structures capable communicating through membrane contact sites (MCSs). MCSs been identified as key pathways mediating inter-organelle communication crosstalk in neurons, their alterations disease pathology. The endoplasmic reticulum (ER) membrane-bound forming an extensive network pools tubules with important physiological functions within neurons. There multiple between ER other plasma (PM), which regulate variety processes. this review, we focus on ER-organelle role We compared biological effects different tethering proteins respective counterparts. also discuss how altered contacts may affect pathogenesis. Therefore, understanding molecular mechanisms neuronal will lay foundation for development new therapies targeting contacts.

Язык: Английский

Процитировано

0

Human neural stem cells derived from fetal human brain communicate each other and rescue ischemic neurons through tunneling nanotubes DOI Creative Commons
Francesco Pisani,

D. L. Capobianco,

Roberta De Zio

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Abstract Pre-clinical trials have demonstrated the neuroprotective effects of transplanted human neural stem cells (hNSCs) during post-ischemic phase. However, exact mechanism remains unclear. Tunneling nanotubes (TNTs) are long plasma membrane bridges that physically connect distant cells, enabling intercellular transfer mitochondria, contributing to repair processes. Whether hNSCs communicate through TNTs and their role in neuroprotection remain unknown. In this study, non-immortalized hNSC lines derived from fetal brain tissues were examined explore these possibilities assess potential hNSCs. Using Tau-STED super-resolution confocal microscopy, live cell time-lapse fluorescence electron direct or non-contact homotypic co-cultures, we generate nestin-positive both 3D neurospheres 2D cultures, though which they functional mitochondria. Co-culturing with neurons revealed heterotypic allowing mitochondrial neurons. To investigate neuroprotection, subjected oxygen-glucose deprivation (OGD) followed by reoxygenation (OGD/R) without co-cultures. Compared normoxia, OGD/R became apoptotic impaired electrical activity. When co-cultured contact hNSCs, enabled mitochondria neurons, rescuing them apoptosis restoring bioelectrical profile toward normoxic This complete did not occur co-culture. summary, our data reveal presence a network containing nestin within demonstrate involvement mediated highlight strong efficacy neuroprotection.

Язык: Английский

Процитировано

0

Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review DOI Creative Commons

Daqiang Zhou,

Sibo Yang,

Jiehong Wu

и другие.

Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Despite substantial evidence highlighting molecular communication within the components of neurovascular units (NVU), interactions at organelle level have been insufficiently explored in recent decades. Mitochondria, for instance, beyond their traditional role as energy supply intracellular metabolism and survival, provide a novel perspective on intercellular connections through mitochondrial transfer. These transferred mitochondria not only carry bioactive molecules but also signal to mitigate risks both healthy pathological conditions. In this review, we summarized transfer events, relevant routes, underlying mechanisms originating from diverse cell populations NVU. We particularly focus therapeutic potential mechanism treating central nervous system disorders, notably neurodegenerative diseases marked by dysfunction then highlight promising prospects exogenous supplementation treatment target.

Язык: Английский

Процитировано

0

Mitochondrial dysfunction and Alzheimer’s disease: pathogenesis of mitochondrial transfer DOI Creative Commons
Yun Wei, Xiaofei Du, Hongling Guo

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Дек. 17, 2024

In recent years, mitochondrial transfer has emerged as a universal phenomenon intertwined with various systemic physiological and pathological processes. Alzheimer's disease (AD) is multifactorial disease, dysfunction at its core. Although numerous studies have found evidence of in AD models, the precise mechanisms remain unclear. Recent revealed dynamic mitochondria not only between nerve cells glial cells, but also cells. this review, we explore pathways how these activities contribute to progression.

Язык: Английский

Процитировано

0