Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Дек. 17, 2024
In
recent
years,
mitochondrial
transfer
has
emerged
as
a
universal
phenomenon
intertwined
with
various
systemic
physiological
and
pathological
processes.
Alzheimer's
disease
(AD)
is
multifactorial
disease,
dysfunction
at
its
core.
Although
numerous
studies
have
found
evidence
of
in
AD
models,
the
precise
mechanisms
remain
unclear.
Recent
revealed
dynamic
mitochondria
not
only
between
nerve
cells
glial
cells,
but
also
cells.
this
review,
we
explore
pathways
how
these
activities
contribute
to
progression.
Journal of Molecular Pathology,
Год журнала:
2023,
Номер
4(4), С. 333 - 348
Опубликована: Дек. 9, 2023
The
following
review
considers
current
concepts
concerning
the
characteristics
of
DRP1-related
mitochondrial
division
in
brain
cells
during
hypoxic-ischemic
pathology.
functional
role
DRP1
neurons
and
astroglia
cerebral
ischemia
conditions
was
analyzed.
We
discuss
potential
for
regulating
activity
through
selective
inhibitor
fission,
mdivi-1.
article
also
presents
data
on
involvement
astro-
microglia-mediated
intercellular
transport.
Understanding
molecular
mechanisms
responsible
fission
exposure
will
allow
us
to
consider
as
an
effective
therapeutic
target
treating
with
a
hypoxic
component.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107149 - 107149
Опубликована: Март 20, 2024
Neuronal
health
is
closely
linked
to
the
homeostasis
of
intracellular
organelles,
and
organelle
dysfunction
affects
pathological
progression
neurological
diseases.
In
contrast
isolated
cellular
compartments,
a
growing
number
studies
have
found
that
organelles
are
largely
interdependent
structures
capable
communicating
through
membrane
contact
sites
(MCSs).
MCSs
been
identified
as
key
pathways
mediating
inter-organelle
communication
crosstalk
in
neurons,
their
alterations
disease
pathology.
The
endoplasmic
reticulum
(ER)
membrane-bound
forming
an
extensive
network
pools
tubules
with
important
physiological
functions
within
neurons.
There
multiple
between
ER
other
plasma
(PM),
which
regulate
variety
processes.
this
review,
we
focus
on
ER-organelle
role
We
compared
biological
effects
different
tethering
proteins
respective
counterparts.
also
discuss
how
altered
contacts
may
affect
pathogenesis.
Therefore,
understanding
molecular
mechanisms
neuronal
will
lay
foundation
for
development
new
therapies
targeting
contacts.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 28, 2024
Abstract
Pre-clinical
trials
have
demonstrated
the
neuroprotective
effects
of
transplanted
human
neural
stem
cells
(hNSCs)
during
post-ischemic
phase.
However,
exact
mechanism
remains
unclear.
Tunneling
nanotubes
(TNTs)
are
long
plasma
membrane
bridges
that
physically
connect
distant
cells,
enabling
intercellular
transfer
mitochondria,
contributing
to
repair
processes.
Whether
hNSCs
communicate
through
TNTs
and
their
role
in
neuroprotection
remain
unknown.
In
this
study,
non-immortalized
hNSC
lines
derived
from
fetal
brain
tissues
were
examined
explore
these
possibilities
assess
potential
hNSCs.
Using
Tau-STED
super-resolution
confocal
microscopy,
live
cell
time-lapse
fluorescence
electron
direct
or
non-contact
homotypic
co-cultures,
we
generate
nestin-positive
both
3D
neurospheres
2D
cultures,
though
which
they
functional
mitochondria.
Co-culturing
with
neurons
revealed
heterotypic
allowing
mitochondrial
neurons.
To
investigate
neuroprotection,
subjected
oxygen-glucose
deprivation
(OGD)
followed
by
reoxygenation
(OGD/R)
without
co-cultures.
Compared
normoxia,
OGD/R
became
apoptotic
impaired
electrical
activity.
When
co-cultured
contact
hNSCs,
enabled
mitochondria
neurons,
rescuing
them
apoptosis
restoring
bioelectrical
profile
toward
normoxic
This
complete
did
not
occur
co-culture.
summary,
our
data
reveal
presence
a
network
containing
nestin
within
demonstrate
involvement
mediated
highlight
strong
efficacy
neuroprotection.
Aging and Disease,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Despite
substantial
evidence
highlighting
molecular
communication
within
the
components
of
neurovascular
units
(NVU),
interactions
at
organelle
level
have
been
insufficiently
explored
in
recent
decades.
Mitochondria,
for
instance,
beyond
their
traditional
role
as
energy
supply
intracellular
metabolism
and
survival,
provide
a
novel
perspective
on
intercellular
connections
through
mitochondrial
transfer.
These
transferred
mitochondria
not
only
carry
bioactive
molecules
but
also
signal
to
mitigate
risks
both
healthy
pathological
conditions.
In
this
review,
we
summarized
transfer
events,
relevant
routes,
underlying
mechanisms
originating
from
diverse
cell
populations
NVU.
We
particularly
focus
therapeutic
potential
mechanism
treating
central
nervous
system
disorders,
notably
neurodegenerative
diseases
marked
by
dysfunction
then
highlight
promising
prospects
exogenous
supplementation
treatment
target.
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Дек. 17, 2024
In
recent
years,
mitochondrial
transfer
has
emerged
as
a
universal
phenomenon
intertwined
with
various
systemic
physiological
and
pathological
processes.
Alzheimer's
disease
(AD)
is
multifactorial
disease,
dysfunction
at
its
core.
Although
numerous
studies
have
found
evidence
of
in
AD
models,
the
precise
mechanisms
remain
unclear.
Recent
revealed
dynamic
mitochondria
not
only
between
nerve
cells
glial
cells,
but
also
cells.
this
review,
we
explore
pathways
how
these
activities
contribute
to
progression.
