Journal of Molecular Pathology,
Journal Year:
2023,
Volume and Issue:
4(4), P. 333 - 348
Published: Dec. 9, 2023
The
following
review
considers
current
concepts
concerning
the
characteristics
of
DRP1-related
mitochondrial
division
in
brain
cells
during
hypoxic-ischemic
pathology.
functional
role
DRP1
neurons
and
astroglia
cerebral
ischemia
conditions
was
analyzed.
We
discuss
potential
for
regulating
activity
through
selective
inhibitor
fission,
mdivi-1.
article
also
presents
data
on
involvement
astro-
microglia-mediated
intercellular
transport.
Understanding
molecular
mechanisms
responsible
fission
exposure
will
allow
us
to
consider
as
an
effective
therapeutic
target
treating
with
a
hypoxic
component.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12110 - 12110
Published: Nov. 11, 2024
Schizophrenia
is
a
severe
neuropsychiatric
illness
of
uncertain
etiopathogenesis
in
which
antipsychotic
drugs
can
attenuate
the
symptoms,
but
patients
rarely
return
to
premorbid
level
functioning.
In
fact,
with
each
relapse,
people
living
schizophrenia
progress
toward
disability
and
cognitive
impairment.
Moreover,
our
desire
live
normal
lives,
manage
their
daily
affairs
independently,
date,
get
married,
raise
support
family.
Those
us
who
work
know
that
these
objectives
are
met
despite
novel
allegedly
improved
dopamine
blockers.
We
hypothesize
poor
outcomes
reflect
gray
matter
volume
reduction,
continues
treatment.
further
increased
gut
barrier
permeability,
due
dysfunctional
aryl
hydrocarbon
receptor
(AhR),
downregulates
protectors,
brain-derived
neurotrophic
factor
(BDNF),
interleukin-22
(IL-22),
facilitating
microbial
translocation
into
systemic
circulation,
eventually
reaching
brain.
Recombinant
human
IL-22
could
ameliorate
outcome
by
limiting
bacterial
initiating
tissue
repair.
This
short
review
examines
signal
transducer
transcription-three
(STAT3)/AhR
axis
downregulation
BDNF
subsequent
increase
permeability.
Based
on
hypothesis
presented
here,
we
discuss
alternative
interventions,
including
AhR
antagonists,
mitochondrial
transplant,
membrane
lipid
replacement,
recombinant
IL-22.
Frontiers in Aging Neuroscience,
Journal Year:
2024,
Volume and Issue:
16
Published: Dec. 17, 2024
In
recent
years,
mitochondrial
transfer
has
emerged
as
a
universal
phenomenon
intertwined
with
various
systemic
physiological
and
pathological
processes.
Alzheimer's
disease
(AD)
is
multifactorial
disease,
dysfunction
at
its
core.
Although
numerous
studies
have
found
evidence
of
in
AD
models,
the
precise
mechanisms
remain
unclear.
Recent
revealed
dynamic
mitochondria
not
only
between
nerve
cells
glial
cells,
but
also
cells.
this
review,
we
explore
pathways
how
these
activities
contribute
to
progression.
Abstract
Mitochondria
are
versatile
and
complex
organelles
that
can
continuously
communicate
interact
with
the
cellular
milieu.
Deregulated
communication
between
mitochondria
host
cells/organelles
has
significant
consequences
is
an
underlying
factor
of
many
pathophysiological
conditions,
including
process
aging.
During
aging,
lose
function,
mitocellular
pathways
break
down;
mitochondrial
dysfunction
interacts
dyscommunication,
forming
a
vicious
circle.
Therefore,
strategies
to
protect
function
promote
effective
increase
healthy
lifespan
longevity,
which
might
be
new
treatment
paradigm
for
age-related
disorders.
In
this
review,
we
comprehensively
discuss
signal
transduction
mechanisms
inter-
intracellular
communication,
as
well
interactions
hallmarks
This
review
emphasizes
indispensable
position
in
aging
organisms,
crucial
signaling
hubs.
addition,
also
specifically
focus
on
status
mitochondria-targeted
interventions
provide
potential
therapeutic
targets
diseases.
Graphical
Journal of Molecular Pathology,
Journal Year:
2023,
Volume and Issue:
4(4), P. 333 - 348
Published: Dec. 9, 2023
The
following
review
considers
current
concepts
concerning
the
characteristics
of
DRP1-related
mitochondrial
division
in
brain
cells
during
hypoxic-ischemic
pathology.
functional
role
DRP1
neurons
and
astroglia
cerebral
ischemia
conditions
was
analyzed.
We
discuss
potential
for
regulating
activity
through
selective
inhibitor
fission,
mdivi-1.
article
also
presents
data
on
involvement
astro-
microglia-mediated
intercellular
transport.
Understanding
molecular
mechanisms
responsible
fission
exposure
will
allow
us
to
consider
as
an
effective
therapeutic
target
treating
with
a
hypoxic
component.
