Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex DOI Creative Commons

Zhuo-Yu Ren,

Bao-Yu Han,

Liyuan Zhao

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Abstract Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions of this anxiety are highly limited. This study aims to examine the effect environmental enrichment (EE) on spared nerve injury (SNI)-induced pain-associated behaviors and explore mechanisms underlying effect. EE could effectively ameliorate anxiety-like followed by SNI. also significantly reversed phenotypic loss parvalbumin (PV) interneurons in anterior cingulate cortex (ACC) impaired gamma oscillations under SNI-induced conditions. In addition, reduction number PV puncta around Ca²⁺/calmodulin-dependent protein kinase II-positive neurons. Furthermore, enhancing function improve SNI-caused behaviors. contrast, inhibiting led native mice. Our findings suggest that improves conditions likely ACC.

Язык: Английский

Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex DOI Creative Commons

Zhuo-Yu Ren,

Bao-Yu Han,

Liyuan Zhao

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 24, 2025

Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions for this anxiety are highly limited. This study aims to examine the effect of environmental enrichment (EE) on spared nerve injury (SNI)-induced pain-associated behaviors and explore mechanisms underlying effect. EE effectively ameliorated anxiety-like followed by SNI. also significantly reversed phenotypic loss parvalbumin (PV) interneurons in anterior cingulate cortex (ACC) impaired gamma oscillations under SNI-induced conditions. In addition, reduction number PV puncta around Ca²⁺/calmodulin-dependent protein kinase II-positive neurons. Furthermore, enhancing function could improve SNI-caused behaviors. contrast, inhibition led naïve mice. Our findings suggest that improves conditions, likely ACC.

Язык: Английский

Процитировано

0
Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice DOI Creative Commons

Wei‐tong Pan,

Hanwen Gu, Yanbo Zhou

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Photo‐biomodulation (PBM) with near‐infrared (NIR) laser emerges as a promising noninvasive therapy for enhancing cognitive function. Here the effects of PBM, equipped an 808 nm NIR laser, on function are investigated when used to irradiate hippocampi mice. irradiation once day 5 min per consecutive days significantly improves learning and memory performance naïve mice assessed Barnes Y maze tests. PBM also attenuates dysfunction following anesthesia surgery, lipopolysaccharide challenge, respectively. Cognitive enhancements associated increased neuronal oscillations enhanced theta–gamma coupling in hippocampal dentate gyrus (DG) during processing. High activation DG is evidenced by c‐Fos expression calcium signal intensity. The improvements high‐density cells together facilitating local energy deposition activation. NIR‐laser‐activated axonogenesis oxidative phosphorylation‐related genes single‐cell RNA sequencing were seen DG. These findings suggest that very likely holds great potential dysfunction.

Язык: Английский

Процитировано

0
SynCAM1 deficiency in the hippocampal parvalbumin interneurons contributes to sevoflurane‐induced cognitive impairment in neonatal rats DOI Creative Commons

Ming‐ming Zhao,

Hanwen Gu,

Wei‐tong Pan

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2023, Номер 30(1)

Опубликована: Дек. 17, 2023

Sevoflurane is widely used for general anesthesia in children. Previous studies reported that multiple neonatal exposures to sevoflurane can induce long-term cognitive impairment adolescent rats, but the underlying mechanisms were not defined.

Язык: Английский

Процитировано

7
Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation-induced cognitive impairment in mice DOI
Kai Liu,

Yu-Zhu Gao,

Xinmiao Wu

и другие.

Neuropharmacology, Год журнала: 2024, Номер 262, С. 110205 - 110205

Опубликована: Ноя. 2, 2024

Язык: Английский

Процитировано

2
P2X7 receptors: a bibliometric review from 2002 to 2023 DOI

Haiting Tang,

Wei Wei,

Yu Luo

и другие.

Purinergic Signalling, Год журнала: 2024, Номер unknown

Опубликована: Фев. 29, 2024

Язык: Английский

Процитировано

1
Rutin Ameliorates the Sevoflurane-Induced Neurotoxicity by Inhibiting Microglial Synaptic Phagocytosis DOI

H Wang,

Miaomiao Xiong,

Zhiguo Jiang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex DOI Creative Commons

Zhuo-Yu Ren,

Bao-Yu Han,

Liyuan Zhao

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Abstract Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions of this anxiety are highly limited. This study aims to examine the effect environmental enrichment (EE) on spared nerve injury (SNI)-induced pain-associated behaviors and explore mechanisms underlying effect. EE could effectively ameliorate anxiety-like followed by SNI. also significantly reversed phenotypic loss parvalbumin (PV) interneurons in anterior cingulate cortex (ACC) impaired gamma oscillations under SNI-induced conditions. In addition, reduction number PV puncta around Ca²⁺/calmodulin-dependent protein kinase II-positive neurons. Furthermore, enhancing function improve SNI-caused behaviors. contrast, inhibiting led native mice. Our findings suggest that improves conditions likely ACC.

Язык: Английский

Процитировано

0