Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex DOI Creative Commons

Zhuo-Yu Ren,

Bao-Yu Han,

Liyuan Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions of this anxiety are highly limited. This study aims to examine the effect environmental enrichment (EE) on spared nerve injury (SNI)-induced pain-associated behaviors and explore mechanisms underlying effect. EE could effectively ameliorate anxiety-like followed by SNI. also significantly reversed phenotypic loss parvalbumin (PV) interneurons in anterior cingulate cortex (ACC) impaired gamma oscillations under SNI-induced conditions. In addition, reduction number PV puncta around Ca²⁺/calmodulin-dependent protein kinase II-positive neurons. Furthermore, enhancing function improve SNI-caused behaviors. contrast, inhibiting led native mice. Our findings suggest that improves conditions likely ACC.

Language: Английский

Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex DOI Creative Commons

Zhuo-Yu Ren,

Bao-Yu Han,

Liyuan Zhao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 24, 2025

Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions for this anxiety are highly limited. This study aims to examine the effect of environmental enrichment (EE) on spared nerve injury (SNI)-induced pain-associated behaviors and explore mechanisms underlying effect. EE effectively ameliorated anxiety-like followed by SNI. also significantly reversed phenotypic loss parvalbumin (PV) interneurons in anterior cingulate cortex (ACC) impaired gamma oscillations under SNI-induced conditions. In addition, reduction number PV puncta around Ca²⁺/calmodulin-dependent protein kinase II-positive neurons. Furthermore, enhancing function could improve SNI-caused behaviors. contrast, inhibition led naïve mice. Our findings suggest that improves conditions, likely ACC.

Language: Английский

Citations

0
Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice DOI Creative Commons

Wei‐tong Pan,

Hanwen Gu, Yanbo Zhou

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Photo‐biomodulation (PBM) with near‐infrared (NIR) laser emerges as a promising noninvasive therapy for enhancing cognitive function. Here the effects of PBM, equipped an 808 nm NIR laser, on function are investigated when used to irradiate hippocampi mice. irradiation once day 5 min per consecutive days significantly improves learning and memory performance naïve mice assessed Barnes Y maze tests. PBM also attenuates dysfunction following anesthesia surgery, lipopolysaccharide challenge, respectively. Cognitive enhancements associated increased neuronal oscillations enhanced theta–gamma coupling in hippocampal dentate gyrus (DG) during processing. High activation DG is evidenced by c‐Fos expression calcium signal intensity. The improvements high‐density cells together facilitating local energy deposition activation. NIR‐laser‐activated axonogenesis oxidative phosphorylation‐related genes single‐cell RNA sequencing were seen DG. These findings suggest that very likely holds great potential dysfunction.

Language: Английский

Citations

0
SynCAM1 deficiency in the hippocampal parvalbumin interneurons contributes to sevoflurane‐induced cognitive impairment in neonatal rats DOI Creative Commons

Ming‐ming Zhao,

Hanwen Gu,

Wei‐tong Pan

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(1)

Published: Dec. 17, 2023

Sevoflurane is widely used for general anesthesia in children. Previous studies reported that multiple neonatal exposures to sevoflurane can induce long-term cognitive impairment adolescent rats, but the underlying mechanisms were not defined.

Language: Английский

Citations

7
Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation-induced cognitive impairment in mice DOI
Kai Liu,

Yu-Zhu Gao,

Xinmiao Wu

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 262, P. 110205 - 110205

Published: Nov. 2, 2024

Language: Английский

Citations

2
P2X7 receptors: a bibliometric review from 2002 to 2023 DOI

Haiting Tang,

Wei Wei,

Yu Luo

et al.

Purinergic Signalling, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 29, 2024

Language: Английский

Citations

1
Rutin Ameliorates the Sevoflurane-Induced Neurotoxicity by Inhibiting Microglial Synaptic Phagocytosis DOI

H Wang,

Miaomiao Xiong,

Zhiguo Jiang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Environmental enrichment alleviates neuropathic pain-associated anxiety by enhancing the function of parvalbumin interneurons in the anterior cingulate cortex DOI Creative Commons

Zhuo-Yu Ren,

Bao-Yu Han,

Liyuan Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Chronic neuropathic pain is often accompanied with comorbid anxiety. However, effective interventions of this anxiety are highly limited. This study aims to examine the effect environmental enrichment (EE) on spared nerve injury (SNI)-induced pain-associated behaviors and explore mechanisms underlying effect. EE could effectively ameliorate anxiety-like followed by SNI. also significantly reversed phenotypic loss parvalbumin (PV) interneurons in anterior cingulate cortex (ACC) impaired gamma oscillations under SNI-induced conditions. In addition, reduction number PV puncta around Ca²⁺/calmodulin-dependent protein kinase II-positive neurons. Furthermore, enhancing function improve SNI-caused behaviors. contrast, inhibiting led native mice. Our findings suggest that improves conditions likely ACC.

Language: Английский

Citations

0