The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1222 - 1222

Опубликована: Янв. 30, 2025

Alzheimer’s disease (AD) is one of the most common and severe forms dementia neurodegenerative disease. As life expectancy increases in line with developments medicine, elderly population projected to increase next few decades; therefore, an prevalence some diseases, such as AD, also expected. a result, until radical treatment becomes available, AD expected be more frequently recorded top causes death worldwide. Given current lack cure for only treatments available being ones that alleviate major symptoms, identification contributing factors influence incidence crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions these are assessed. review, we conducted literature search focusing on environmental air pollution, toxic elements, pesticides, infectious agents, well dietary including various diets, vitamin D deficiency, social (e.g., tobacco alcohol use), variables affected by both behavior gut microbiota. We evaluated studies beneficial effects antibiotics Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) Mediterranean diets.

Язык: Английский

Transthyretin as a therapeutic target: the future of disease-modifying therapies for Alzheimer’s disease

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 8, 2025

Язык: Английский

Metabolic fingerprinting of human plasma in dementia: A pilot study of metabolome decomposition

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 343, С. 126507 - 126507

Опубликована: Июнь 2, 2025

Язык: Английский