The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1222 - 1222

Published: Jan. 30, 2025

Alzheimer’s disease (AD) is one of the most common and severe forms dementia neurodegenerative disease. As life expectancy increases in line with developments medicine, elderly population projected to increase next few decades; therefore, an prevalence some diseases, such as AD, also expected. a result, until radical treatment becomes available, AD expected be more frequently recorded top causes death worldwide. Given current lack cure for only treatments available being ones that alleviate major symptoms, identification contributing factors influence incidence crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions these are assessed. review, we conducted literature search focusing on environmental air pollution, toxic elements, pesticides, infectious agents, well dietary including various diets, vitamin D deficiency, social (e.g., tobacco alcohol use), variables affected by both behavior gut microbiota. We evaluated studies beneficial effects antibiotics Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) Mediterranean diets.

Language: Английский

Transthyretin as a therapeutic target: the future of disease-modifying therapies for Alzheimer’s disease

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 8, 2025

Language: Английский