The Interplay of Mitochondrial Dysfunction in Oral Diseases: Recent Updates in Pathogenesis and Therapeutic Implications
Al-Hassan Soliman Wadan,
Mohamed Abdelsattar Ahmed,
Abdelnaser Hussein Ahmed
и другие.
Mitochondrion,
Год журнала:
2024,
Номер
78, С. 101942 - 101942
Опубликована: Авг. 6, 2024
Язык: Английский
Mitochondrial Dysfunction in the Pathogenesis and Treatment of Oral Inflammatory Diseases
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15483 - 15483
Опубликована: Окт. 23, 2023
Oral
inflammatory
diseases
(OIDs)
include
many
common
such
as
periodontitis
and
pulpitis.
The
causes
of
OIDs
consist
microorganism,
trauma,
occlusal
factors,
autoimmune
dis-eases
radiation
therapy.
When
treated
unproperly,
not
only
affect
oral
health
but
also
pose
threat
to
people’s
overall
condition.
Therefore,
identifying
at
an
early
stage
exploring
new
therapeutic
strategies
are
important
tasks
for
oral-related
research.
Mitochondria
crucial
organelles
cellular
activities
disruptions
mitochondrial
function
metabolism
indirectly
influence
life
span.
Mitochondrial
dysfunction
has
been
implicated
in
polygenic
diseases,
including
cardiovascular
neurodegenerative
diseases.
Recently,
increasing
evidence
suggests
that
plays
a
critical
role
the
development
progression
its
associated
systemic
In
this
review,
we
elucidated
insights
into
involvement
responses
OIDs.
We
summarized
recent
research
progresses
on
treatment
targeting
discussed
underlying
mechanisms.
Язык: Английский
A Cerium Oxide Loaded Hyaluronic Acid Nanosystem Remits Glucose Oxidative Stress-Induced Odontoblasts Mitochondrial Apoptosis through Regulation of PGAM5 Pathway
Chuchu Zheng,
Xiangyu Hu,
Ruize Hua
и другие.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
Diabetes
mellitus
(DM)
induced
mitochondrial
oxidative
stress
(OS)
can
lead
to
severe
injury
of
dental
pulp.
The
cerium
oxide
nanoparticles
(CNP)
have
been
proven
excellent
antioxidative
activity.
However,
whether
CNP
relieve
pulp
damage
caused
by
DM
and
the
underlying
mechanisms
remain
unclear.
In
this
study,
we
modified
ceria
with
hyaluronic
acid
prepare
nanoceria
good
biocompatibility,
water
solubility,
stability,
namely,
HACNP
(hyaluronic
nanoparticles).
We
demonstrated
protective
effect
on
diabetic
OS-induced
apoptosis
in
pulp-like
cells.
As
far
as
mechanism
action
was
concerned,
glucose
oxidase
(GO)
treatment
promoted
activation
phosphoglycerate
mutase
family
5
(PGAM5)
leading
abnormalities
an
odontoblast-like
cell
line
(mDPC6T).
Knockdown
or
overexpression
PGAM5
further
validate
these
results.
Meanwhile,
remitted
GO-related
toxicity
via
down-regulating
expression,
whereas
abolished
beneficial
HACNP.
Furthermore,
constructed
animal
research
model
injury,
also
confirmed
that
alleviated
decreased
expression
level
tissue.
conclusion,
results
revealed
played
a
role
diabetes-associated
through
targeting
PGAM5-mediated
pathway,
providing
idea
method
for
prevention
diabetes-induced
damage.
Язык: Английский
Mitochondrial function in oral health and disease
Journal of Immunological Methods,
Год журнала:
2024,
Номер
532, С. 113729 - 113729
Опубликована: Июль 26, 2024
Monitoring
mitochondrial
function
and
quality
control
in
tissues
is
a
crucial
aspect
of
understanding
cellular
health
dysfunction,
which
may
inform
about
the
pathogenesis
several
conditions
associated
with
aging,
including
chronic
inflammatory
conditions,
neurodegenerative
disorders
metabolic
diseases.
This
process
involves
assessing
functionality,
integrity,
abundance
mitochondria
within
cells.
Several
lines
evidence
have
explored
techniques
methods
for
monitoring
tissues.
In
this
review,
we
summarize
provide
our
perspective
considering
latest
oral
disease
particular
focus
periodontal
inflammation.
research
significant
gaining
insights
into
pathophysiology
disease,
dysbiosis-related,
immune
mediated
age-associated
condition
representing
burden
to
US
elderly
population.
Approaches
status
reviewed
here
include
dynamics,
mitophagy,
biogenesis,
oxidative
stress,
electron
transport
chain
metabolomics.
Such
assessments
help
researchers
comprehend
role
homeostasis
its
implications
Язык: Английский
The mitochondrial‐endoplasmic reticulum co‐transfer in dental pulp stromal cell promotes pulp injury repair
Cell Proliferation,
Год журнала:
2023,
Номер
57(1)
Опубликована: Июль 26, 2023
Abstract
Dental
pulp
injury
remains
a
clinical
challenge
with
limited
therapeutic
approaches.
In
the
present
study,
we
sought
to
prove
that
dental
stromal
cells
(DPSCs)
mitochondrial
transfer
could
promote
repair
and
endoplasmic
reticulum
(ER)‐mitochondrial
contacts
have
significant
regulatory
effect
on
transfer.
Healthy
DPSCs
were
co‐cultured
directly
or
indirectly
injured
in
first
molar
of
1–2
month
SD
rats
vitro.
Mitochondrial
was
observed
after
24
h
co‐culture
using
fluorescence
microscopy
live
cell
workstation.
After
for
1W,
8‐OhdG
immunofluorescence,
membrane
potential
total
oxidant
status/total
antioxidant
status
used
detect
function
before
Subsequently,
mitochondria‐ER
co‐transfer
regulated
by
modulating
binding
healthy
DPSCs,
results
GRP78
CHOP
PDI
immunofluorescence
haematoxylin
eosin
staining
tissue
analysed
clarify
effects
stress
(ERS),
repair.
Fluorescence
workstation
showed
between
DPSCs.
Meanwhile,
significantly
restored
By
mitochondrial‐ER
binding,
efficiency
affected
had
an
impact
ERS
cells.
promotes
pulpal
functional
recovery
damaged
is
binding.
Язык: Английский
GDF11 promotes osteogenic/odontogenic differentiation of dental pulp stem cells to accelerate dentin restoration via modulating SIRT3/FOXO3-mediated mitophagy
Mingsi Deng,
Ruimin Tang,
Yani Xu
и другие.
International Immunopharmacology,
Год журнала:
2024,
Номер
142, С. 113092 - 113092
Опубликована: Сен. 23, 2024
Язык: Английский
THE ROLE OF MITOCHONDRIAL DYSFUNCTION IN THE PATHOGENESIS AND TREATMENT OF INFLAMMATORY DISEASES IN THE ORAL CAVITY
Russian Journal of Dentistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 10, 2024
Inflammatory
diseases
of
the
oral
cavity
(IOD)
include
many
common
such
as
periodontitis
and
pulpitis.
The
main
causes
IOD
are
microorganisms,
trauma,
occlusive
factors,
autoimmune
radiation
therapy.
If
not
treated
correctly,
can
only
affect
health,
but
also
pose
a
threat
to
people's
overall
health.
Therefore,
identifying
at
an
early
stage
exploring
new
therapeutic
strategies
important
research
goals
related
Mitochondria
essential
organelles
for
cellular
processes.
Mitochondrial
dysfunction
affects
metabolism,
indirectly
health
life
expectancy.
is
implicated
in
polygenic
diseases,
including
cardiovascular
neurodegenerative
diseases.
Recently,
increasing
evidence
suggests
that
mitochondrial
plays
critical
role
development
progression
associated
systemic
This
review
outlines
insights
into
its
inflammatory
responses
IOD.
results
recent
studies
field
treatment
IOD,
aimed
dysfunction,
presented,
underlying
mechanisms
considered.
Язык: Английский