Engineering a pH‐responsive polymeric micelle co‐loaded with paclitaxel and triptolide for breast cancer therapy
Cell Proliferation,
Год журнала:
2024,
Номер
57(6)
Опубликована: Янв. 16, 2024
Abstract
Breast
cancer
has
overtaken
lung
as
the
number
one
worldwide.
Paclitaxel
(PTX)
is
a
widely
used
first‐line
anti‐cancer
drug,
but
it
not
very
effective
in
clinical
breast
therapy.
It
been
reported
that
triptolide
(TPL)
can
enhance
anticancer
effect
of
paclitaxel,
and
better
synergistic
therapeutic
effects
are
seen
with
concomitant
administration
PTX
TPL.
In
this
study,
we
developed
pH‐responsive
polymeric
micelles
for
co‐delivery
TPL,
which
disassembling
acidic
tumour
microenvironments
to
target
drug
release
effectively
kill
cells.
Firstly,
synthesized
amphiphilic
copolymer
mPEG
2000
‐PBAE
through
Michael
addition
reaction,
confirmed
by
various
characterizations.
Polymer
loaded
TPL
(TPL/PTX‐PMs)
were
prepared
thin
film
dispersion
method.
The
average
particle
size
TPL/PTX‐PMs
was
97.29
±
1.63
nm,
PDI
0.237
0.003
Zeta
potential
9.57
0.80
mV,
LC%
6.19
0.21%,
EE%
88.67
3.06%.
Carrier
material
biocompatibility
micelle
cytotoxicity
assessed
using
CCK‐8
method,
demonstrating
excellent
biocompatibility.
Under
same
concentration,
most
toxic
cells
had
strongest
proliferation
inhibitory
effect.
Cellular
uptake
assays
revealed
significantly
increased
intracellular
concentration
enhanced
antitumor
activity.
Overall,
micellar
promising
approach
Язык: Английский
Triptolide's Impact on ACER1 Signaling: Inducing Autophagy for Triple-Negative Breast Cancer Suppression
Lingyue Huang,
Rui Xue,
Mingfei Zhu
и другие.
Pathology - Research and Practice,
Год журнала:
2025,
Номер
unknown, С. 155823 - 155823
Опубликована: Янв. 1, 2025
Язык: Английский
pH-responsive carbohydrate polymer-based nanoparticles in cancer therapy
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 141236 - 141236
Опубликована: Фев. 1, 2025
Язык: Английский
A drug-eluting balloon catheter coated with chitosan and paclitaxel-loaded poloxamer-stabilized PLA microparticles for the effective treatment of cholangiocarcinoma
Journal of Industrial and Engineering Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
αvβ3 integrin aptamer functionalized pH-responsive lipid polymer hybrid nanoparticles for targeted co-delivery of paclitaxel and tamoxifen
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141754 - 141754
Опубликована: Март 4, 2025
Язык: Английский
A self-targeting MOFs nanoplatform for treating metastatic triple-negative breast cancer through tumor microenvironment remodeling and chemotherapy potentiation
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
664, С. 124625 - 124625
Опубликована: Авг. 30, 2024
Язык: Английский
Advances of Stimuli-Responsive Amphiphilic Copolymer Micelles in Tumor Therapy
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 20, С. 1 - 24
Опубликована: Дек. 31, 2024
Abstract:
Amphiphilic
copolymers
are
composed
of
both
hydrophilic
and
hydrophobic
chains,
which
can
self-assemble
into
polymeric
micelles
in
aqueous
solution
via
the
hydrophilic/hydrophobic
interactions.
Due
to
their
unique
properties,
have
been
widely
used
as
drug
carriers.
Poorly
soluble
drugs
be
covalently
attached
polymer
chains
or
non-covalently
incorporated
micelles,
with
improved
pharmacokinetic
profiles
enhanced
efficacy.
In
recent
years,
stimuli-responsive
amphiphilic
copolymer
attracted
significant
attention.
These
respond
specific
stimuli,
including
physical
triggers
(light,
temperature,
etc).
chemical
stimuli
(pH,
redox,
physiological
factors
(enzymes,
ATP,
Under
these
structures
properties
change,
enabling
targeted
therapy
controlled
release
tumors.
strategies
offer
new
avenues
approaches
enhance
tumor
efficacy
reduce
side
effects.
We
will
review
applications
different
types
therapy,
aiming
provide
valuable
guidance
for
future
research
directions
clinical
translation.
Keywords:
stimuli-responsive,
delivery
system
Язык: Английский
Smart hyaluronated micelles to enhance a gemcitabine prodrug efficacy
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
104, С. 106518 - 106518
Опубликована: Дек. 11, 2024
Язык: Английский
Folic Acid-Targeted Mixed Pluronic Micelles for Delivery of Triptolide
Polymers,
Год журнала:
2024,
Номер
16(24), С. 3485 - 3485
Опубликована: Дек. 13, 2024
The
present
study
aimed
to
explore
an
ideal
delivery
system
for
triptolide
(TPL)
by
utilizing
the
thin-film
hydration
method
prepare
drug-loaded,
folate-modified
mixed
pluronic
micelles
(FA–F-127/F-68–TPL).
Scanning
electron
microscopy
and
atomic
force
showed
that
drug-loaded
had
a
spherical
shape
with
small
particle
size,
average
of
30.7
nm.
Cell
viability
experiments
FA–F-127/F-68–TPL
significantly
reduced
HepG2
cell
viability,
exhibiting
strong
cytotoxicity.
Its
cytotoxicity
was
markedly
enhanced
compared
bare
TPL.
Nile
red
(Nr)
used
as
model
drug
FA–F-127/F-68–Nr
further
validate
its
tumor-targeting
cellular
uptake
capability.
After
coincubation
cells,
multifunctional
microplate
reader
intracellular
fluorescence
intensity
increased,
indicating
could
more
effectively
enter
cells.
A
nude
mouse
subcutaneous
hepatocellular
carcinoma
constructed.
Following
tail
vein
injection
FA–F-127/F-68–Nr,
imaging
FA–F127/F-68–Nr
target
tumor
tissue,
even
if
entering
small-sized
challenging,
it
be
excreted
through
urine.
Nude
mice
were
treated
injections
(45
µg/kg)
every
other
day
21
days.
results
growth
transplanted
tumors
slowed,
no
significant
difference
In
summary,
exhibits
advantages
low
cost,
excellent
biological
properties,
active/passive
targeting
capabilities,
notable
against
liver
cancer
inhibition
growth.
Significantly,
FA–F-127/F-68–TPL,
despite
challenges
in
insignificant
EPR
effect,
can
efficiently
via
kidneys,
thereby
preventing
release
during
prolonged
circulation
potential
damage
normal
tissues.
Therefore,
represents
promising
antitumor
system.
Язык: Английский