Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease

Journal of Cardiovascular Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

---

Reduced Expression of Kcnmb1 Leads to Vsmc Phenotypic Switch and Apoptosis

Опубликована: Янв. 1, 2025

Язык: Английский

---

Electrospinning of microspheres with ectodermal mesenchymal stem cells for vascular regeneration

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113716 - 113716

Опубликована: Янв. 1, 2025

Язык: Английский

---

Multi‐Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Background Genome‐wide association studies have revealed numerous loci associated with coronary artery disease (CAD). However, some potential causal/risk genes remain unidentified, and causal therapies are lacking. Methods Results We integrated multi‐omics data from gene methylation, expression, protein levels using summary data‐based Mendelian randomization colocalization analysis. Candidate were prioritized based on protein‐level associations, probability, links to methylation expression. Single‐cell RNA sequencing used assess differential expression in the arteries of patients CAD. TAGLN2 ( Transgelin 2 ), APOB Apolipoprotein B GIP Glucose‐dependent insulinotropic polypeptide ) identified as most strongly CAD, exhibiting significant association. Higher at specific Cytosine‐phosphate‐Guanine sites negatively correlated its a lower risk whereas higher circulating positively CAD (odds ratio,1.66 [95% CI, 1.32–2.08). These results suggest distinct regulatory mechanisms for . In contrast, showed positive associations risk, DHX58 DExH‐box helicase 58 SWAP70 Switch‐associated 70 decreased risk. Conclusions Our findings provide evidence suggesting that , This work provides novel insights into molecular highlights integrating uncover relationships cannot be fully captured by traditional genome‐wide studies.

Язык: Английский

---

Berberine Inhibits Abdominal Aortic Aneurysm Formation and Vascular Smooth Muscle Cell Phenotypic Switching by Regulating the Nrf2 Pathway

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(7)

Опубликована: Апрель 1, 2025

ABSTRACT Abdominal aortic aneurysm (AAA) is a life‐threatening disease featuring extensive membrane destruction in the vascular wall, which closely associated with phenotypic switching of smooth muscle cells (VSMC). A thorough understanding changes regulatory factors during pathogenesis VSMC essential for medical treatments AAA. NRF2 was deemed to hold pivotal position developing AAA, especially as it can regulate switching. In this study, we found that berberine prevents formation AAA by regulating VSMC, well validated both vitro and vivo functional experiments. Mechanically, regulates promoting expression downstream contraction genes through deubiquitination Keap1, deubiquitinating enzyme USP15 plays an important mediating role process.

Язык: Английский

---

Aortic Aneurysm with and without Dissection and Concomitant Atherosclerosis—Differences in a Retrospective Study

Journal of Cardiovascular Development and Disease, Год журнала: 2024, Номер 11(10), С. 311 - 311

Опубликована: Окт. 8, 2024

Thoracic aortic aneurysm is a latent disease with high risk of death. Today, as data are accumulating, an estimation the differences in thoracic men and women different age groups required. The present study evaluated type atherosclerotic lesions males females at ages regarding presence or absence dissection.

Язык: Английский

---