Aortic Aneurysm with and without Dissection and Concomitant Atherosclerosis—Differences in a Retrospective Study DOI Creative Commons
Andrey V. Suslov, Tatiana V. Kirichenko, Andrey V. Omelchenko

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(10), P. 311 - 311

Published: Oct. 8, 2024

Thoracic aortic aneurysm is a latent disease with high risk of death. Today, as data are accumulating, an estimation the differences in thoracic men and women different age groups required. The present study evaluated type atherosclerotic lesions males females at ages regarding presence or absence dissection.

Language: Английский

Electrospinning of microspheres with ectodermal mesenchymal stem cells for vascular regeneration DOI

Jiangnan Yu,

Min Ni,

Kai Liu

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113716 - 113716

Published: Jan. 1, 2025

Language: Английский

Citations

0
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease DOI Creative Commons
Yuanjun Shen, Jason P. Gleghorn

Journal of Cardiovascular Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

0
Reduced Expression of Kcnmb1 Leads to Vsmc Phenotypic Switch and Apoptosis DOI
Hongshan Liu, Xinyuan Zhou, Bo Zuo

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi‐Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease DOI Creative Commons

Qinghua Fang,

Hong-Dan Fan,

Qiaoqiao Li

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Background Genome‐wide association studies have revealed numerous loci associated with coronary artery disease (CAD). However, some potential causal/risk genes remain unidentified, and causal therapies are lacking. Methods Results We integrated multi‐omics data from gene methylation, expression, protein levels using summary data‐based Mendelian randomization colocalization analysis. Candidate were prioritized based on protein‐level associations, probability, links to methylation expression. Single‐cell RNA sequencing used assess differential expression in the arteries of patients CAD. TAGLN2 ( Transgelin 2 ), APOB Apolipoprotein B GIP Glucose‐dependent insulinotropic polypeptide ) identified as most strongly CAD, exhibiting significant association. Higher at specific Cytosine‐phosphate‐Guanine sites negatively correlated its a lower risk whereas higher circulating positively CAD (odds ratio,1.66 [95% CI, 1.32–2.08). These results suggest distinct regulatory mechanisms for . In contrast, showed positive associations risk, DHX58 DExH‐box helicase 58 SWAP70 Switch‐associated 70 decreased risk. Conclusions Our findings provide evidence suggesting that , This work provides novel insights into molecular highlights integrating uncover relationships cannot be fully captured by traditional genome‐wide studies.

Language: Английский

Citations

0
Berberine Inhibits Abdominal Aortic Aneurysm Formation and Vascular Smooth Muscle Cell Phenotypic Switching by Regulating the Nrf2 Pathway DOI Creative Commons

Sanjun Li,

Xiaoyong Xiao,

Yue-Chen Chang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(7)

Published: April 1, 2025

ABSTRACT Abdominal aortic aneurysm (AAA) is a life‐threatening disease featuring extensive membrane destruction in the vascular wall, which closely associated with phenotypic switching of smooth muscle cells (VSMC). A thorough understanding changes regulatory factors during pathogenesis VSMC essential for medical treatments AAA. NRF2 was deemed to hold pivotal position developing AAA, especially as it can regulate switching. In this study, we found that berberine prevents formation AAA by regulating VSMC, well validated both vitro and vivo functional experiments. Mechanically, regulates promoting expression downstream contraction genes through deubiquitination Keap1, deubiquitinating enzyme USP15 plays an important mediating role process.

Language: Английский

Citations

0
Aortic Aneurysm with and without Dissection and Concomitant Atherosclerosis—Differences in a Retrospective Study DOI Creative Commons
Andrey V. Suslov, Tatiana V. Kirichenko, Andrey V. Omelchenko

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(10), P. 311 - 311

Published: Oct. 8, 2024

Thoracic aortic aneurysm is a latent disease with high risk of death. Today, as data are accumulating, an estimation the differences in thoracic men and women different age groups required. The present study evaluated type atherosclerotic lesions males females at ages regarding presence or absence dissection.

Language: Английский

Citations

0