Canadian Journal of Cardiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Obesity, Год журнала: 2022, Номер 30(11), С. 2111 - 2121
Опубликована: Ноя. 1, 2022
Abstract Objective Glucagon‐like peptide‐1 (GLP‐1) receptor agonists recently demonstrated 15% to 20% weight loss in adults with obesity, a range which has previously been achieved only bariatric surgery. This systematic review and meta‐analysis compares between GLP‐1 Methods The databases MEDLINE, MEDLINE In‐Process, Epubs Ahead of Print, Embase Classic + (OvidSP), Cochrane (Wiley) were searched from inception April 21, 2021, for randomized controlled trials observational studies. Two independent reviewers extracted data, reported risk bias, graded certainty evidence. Random‐effects models used pool change weight, BMI, glycated hemoglobin. Results Six studies, encompassing 332 patients, included. Among trials, mean difference all surgery types was −22.68 kg (95% CI: −31.41 −13.96), BMI −8.18 kg/m 2 −11.59 −4.77), hemoglobin −1.28% −1.94% −0.61%). −25.11 −40.61 −9.60), −10.60 −17.22 −3.98). Only one study glycemic outcomes. Conclusion In still confers the highest reductions but similar effects control when compared agonists.
Язык: Английский
Процитировано
52
Current Atherosclerosis Reports, Год журнала: 2022, Номер 24(11), С. 867 - 884
Опубликована: Авг. 31, 2022
Язык: Английский
Процитировано
48
Journal of Clinical Medicine, Год журнала: 2022, Номер 11(15), С. 4315 - 4315
Опубликована: Июль 25, 2022
Due to the increased prevalence of obesity in last decades, bariatric surgery has been on rise recent years. Bariatric is a compelling option for weight loss obese patients with severe obesity-related comorbidities or whom lifestyle modifications have proven ineffective. Redundant skin following significant common occurrence affecting up 96% who undergo surgery, negatively impacting physical and psychosocial health detracting from activities daily living. Statistics American Society Plastic Surgeons show that 46,577 body contouring procedures were performed after massive USA 2020 report. Abdominoplasty, well-established cosmetic procedure improving contour, by removing excess fat abdominal wall thereby restoring musculofascial integrity elasticity, resulting more ideal shape increasing quality life. Although abdominoplasty safe procedure, it associated higher complication rate compared other body-contouring procedures. Technologic advances over past decade developed as non-invasive alternatives adjunctive tools enhance results minimize complications. New energy-based technologies may supplant invasive mild moderate laxity and/or diminish extent scars. surgeons play role life suffer underwent surgery. We are deeply convinced, however, advancement knowledge research this field will determine introduction new custom-made techniques. This reduce rapid reintegration patient into world work resumption activities.
Язык: Английский
Процитировано
40
Molecules, Год журнала: 2023, Номер 28(6), С. 2878 - 2878
Опубликована: Март 22, 2023
Dioscorea spp. belongs to the Dioscoreaceae family, known as “yams”, and contains approximately 600 species with a wide distribution. It is major food source for millions of people in tropical subtropical regions. has great medicinal therapeutic capabilities potential bioactive substances prevention treatment many diseases. In recent years, increasing attention been paid phytochemicals Dioscorea, such steroidal saponins, polyphenols, allantoin, and, particular, polysaccharides diosgenin. These compounds possess anti-inflammatory activity are protective against variety inflammatory diseases, enteritis, arthritis, dermatitis, acute pancreatitis, neuroinflammation. addition, they play an important role metabolic including obesity, dyslipidemia, diabetes, non-alcoholic fatty liver disease. Their mechanisms action related modulation number key signaling pathways molecular targets. This review mainly summarizes studies on its highlights underlying mechanisms. conclusion, promising components develop novel natural
Язык: Английский
Процитировано
39
Nature Metabolism, Год журнала: 2023, Номер 5(3), С. 370 - 384
Опубликована: Март 23, 2023
Язык: Английский
Процитировано
32
Diabetes Therapy, Год журнала: 2024, Номер 15(9), С. 1865 - 1892
Опубликована: Июль 11, 2024
The increasing global incidence of obesity and type 2 diabetes mellitus (T2D) underscores the urgency addressing these interconnected health challenges. Obesity enhances genetic environmental influences on T2D, being not only a primary risk factor but also exacerbating its severity. complex mechanisms linking T2D involve adiposity-driven changes in β-cell function, adipose tissue functioning, multi-organ insulin resistance (IR). Early detection tailored treatment are crucial to mitigate future complications. Moreover, personalized early intensified therapy considering presence comorbidities can delay disease progression diminish cardiorenal Employing combination therapies embracing disease-modifying strategy paramount. Clinical trials provide evidence confirming efficacy safety glucagon-like peptide 1 receptor agonists (GLP-1 RAs). Their use is associated with substantial durable body weight reduction, exceeding 15%, improved glucose control which further translate into prevention, possible remission, improvement cardiometabolic factors Therefore, basis clinical experience current evidence, Eastern Southern Europe Diabetes Expert Group recommends personalized, polymodal approach (comprising GLP-1 RAs) individual patient's phenotype optimize therapy. We expect that availability dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) will significantly contribute modern management continuum.
Язык: Английский
Процитировано
16
The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172167 - 172167
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
15
Applied Sciences, Год журнала: 2024, Номер 14(6), С. 2351 - 2351
Опубликована: Март 11, 2024
The prevalence of diet-related diseases underscores the imperative for innovative management approaches. deployment smart solutions signifies a paradigmatic evolution, capitalising on advanced technologies to enhance precision and efficacy. This paper aims present explore diseases, focusing leveraging technologies, such as connected care, Internet Medical Things (IoMT), remote health monitoring systems (RHMS), address rising diseases. transformative approach is exemplified in case studies tailored RHMS capabilities. showcase potential three introducing novel evaluation method their customisation proactive conditions influenced by dietary habits. RO-SmartAgeing System uniquely addresses age-related aspects, providing an integrated that considers long-term impact choices ageing, marking perspective healthcare. NeuroPredict Platform, complex neuroinformatics, enhances understanding connections between brain health, nutrition, overall well-being, contributing insights healthcare assessments. Focused liver monitoring, HepatoConect system delivers real-time data personalized recommendations, offering distinctive disease management. By integrating cutting-edge these transcend traditional boundaries.
Язык: Английский
Процитировано
11
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(7), С. 2984 - 2987
Опубликована: Апрель 16, 2024
Язык: Английский
Процитировано
11
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(8), С. 3045 - 3057
Опубликована: Май 8, 2024
Abstract Interventions aimed at weight control often have limited effectiveness in combating obesity. This review explores how obesity‐induced dysfunction white (WAT) and brown adipose tissue (BAT), skeletal muscle, the brain blunt loss, leading to retention of stored fat. In obesity, increased adrenergic stimulation inflammation downregulate β‐adrenoreceptors impair catecholaminergic signalling adipocytes. disrupts adrenergic‐mediated lipolysis, diminishing lipid oxidation both adipocytes, lowering thermogenesis blunting fat loss. Emerging evidence suggests that WAT fibrosis is associated with worse loss outcomes; indeed, limiting collagen laminin‐α4 deposition mitigates accumulation, enhances browning, protects against high‐fat‐diet‐induced Obesity compromises mitochondrial oxidative capacity impairing its ability switch between glucose metabolism response varying nutrient levels exercise. dysfunctional phenotype muscle exacerbated presence obesity‐associated sarcopenia. Additionally, obesity suppresses sarcolipin‐induced sarcoplasmic reticulum calcium ATPase (SERCA) activation, resulting reduced capacity, diminished energy expenditure, adiposity. hypothalamus, overnutrition insulin leptin signalling. blunts central satiety signals, favouring a shift balance toward conservation body retention. Moreover, obese animals humans demonstrate impaired dopaminergic responses intake striatum, which tend persist after may result enduring inclinations overeating sedentary lifestyle. Collectively, adaptations described pose significant challenges effectively achieving sustaining
Язык: Английский
Процитировано
11