Obesity Surgery, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Language: Английский
Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1459 - 1459
Published: April 25, 2021
The prevalence of obesity continues to rise worldwide despite evidence-based public health recommendations. promise adopt a healthy lifestyle is increasingly important for tackling this global epidemic. Calorie restriction or regular exercise combination the two accepted as an effective strategy in preventing treating obesity. Furthermore, benefits conferred by overcome are attributed not only reduced adiposity levels circulating lipids but also proteins, peptides, enzymes, and metabolites that released from contracting skeletal muscle other organs. secretion these molecules called cytokines response induces browning white adipose tissue increasing expression brown adipocyte-specific genes within tissue, suggesting exercise-induced may play significant role In review, we present research-based evidence supporting effects various diet interventions on health. We discuss interplay between secreted organs known affect metabolism.
Language: Английский
Citations
61
Obesity, Journal Year: 2022, Volume and Issue: 30(11), P. 2111 - 2121
Published: Nov. 1, 2022
Abstract Objective Glucagon‐like peptide‐1 (GLP‐1) receptor agonists recently demonstrated 15% to 20% weight loss in adults with obesity, a range which has previously been achieved only bariatric surgery. This systematic review and meta‐analysis compares between GLP‐1 Methods The databases MEDLINE, MEDLINE In‐Process, Epubs Ahead of Print, Embase Classic + (OvidSP), Cochrane (Wiley) were searched from inception April 21, 2021, for randomized controlled trials observational studies. Two independent reviewers extracted data, reported risk bias, graded certainty evidence. Random‐effects models used pool change weight, BMI, glycated hemoglobin. Results Six studies, encompassing 332 patients, included. Among trials, mean difference all surgery types was −22.68 kg (95% CI: −31.41 −13.96), BMI −8.18 kg/m 2 −11.59 −4.77), hemoglobin −1.28% −1.94% −0.61%). −25.11 −40.61 −9.60), −10.60 −17.22 −3.98). Only one study glycemic outcomes. Conclusion In still confers the highest reductions but similar effects control when compared agonists.
Language: Английский
Citations
52
Current Atherosclerosis Reports, Journal Year: 2022, Volume and Issue: 24(11), P. 867 - 884
Published: Aug. 31, 2022
Language: Английский
Citations
47
Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2878 - 2878
Published: March 22, 2023
Dioscorea spp. belongs to the Dioscoreaceae family, known as “yams”, and contains approximately 600 species with a wide distribution. It is major food source for millions of people in tropical subtropical regions. has great medicinal therapeutic capabilities potential bioactive substances prevention treatment many diseases. In recent years, increasing attention been paid phytochemicals Dioscorea, such steroidal saponins, polyphenols, allantoin, and, particular, polysaccharides diosgenin. These compounds possess anti-inflammatory activity are protective against variety inflammatory diseases, enteritis, arthritis, dermatitis, acute pancreatitis, neuroinflammation. addition, they play an important role metabolic including obesity, dyslipidemia, diabetes, non-alcoholic fatty liver disease. Their mechanisms action related modulation number key signaling pathways molecular targets. This review mainly summarizes studies on its highlights underlying mechanisms. conclusion, promising components develop novel natural
Language: Английский
Citations
33
Nature Metabolism, Journal Year: 2023, Volume and Issue: 5(3), P. 370 - 384
Published: March 23, 2023
Language: Английский
Citations
31
International Journal of Obesity, Journal Year: 2023, Volume and Issue: 48(2), P. 271 - 275
Published: Nov. 11, 2023
Language: Английский
Citations
23
Diabetes Therapy, Journal Year: 2024, Volume and Issue: 15(9), P. 1865 - 1892
Published: July 11, 2024
The increasing global incidence of obesity and type 2 diabetes mellitus (T2D) underscores the urgency addressing these interconnected health challenges. Obesity enhances genetic environmental influences on T2D, being not only a primary risk factor but also exacerbating its severity. complex mechanisms linking T2D involve adiposity-driven changes in β-cell function, adipose tissue functioning, multi-organ insulin resistance (IR). Early detection tailored treatment are crucial to mitigate future complications. Moreover, personalized early intensified therapy considering presence comorbidities can delay disease progression diminish cardiorenal Employing combination therapies embracing disease-modifying strategy paramount. Clinical trials provide evidence confirming efficacy safety glucagon-like peptide 1 receptor agonists (GLP-1 RAs). Their use is associated with substantial durable body weight reduction, exceeding 15%, improved glucose control which further translate into prevention, possible remission, improvement cardiometabolic factors Therefore, basis clinical experience current evidence, Eastern Southern Europe Diabetes Expert Group recommends personalized, polymodal approach (comprising GLP-1 RAs) individual patient's phenotype optimize therapy. We expect that availability dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) will significantly contribute modern management continuum.
Language: Английский
Citations
15
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172167 - 172167
Published: April 4, 2024
Language: Английский
Citations
14
Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(7), P. 2984 - 2987
Published: April 16, 2024
Language: Английский
Citations
11
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 2351 - 2351
Published: March 11, 2024
The prevalence of diet-related diseases underscores the imperative for innovative management approaches. deployment smart solutions signifies a paradigmatic evolution, capitalising on advanced technologies to enhance precision and efficacy. This paper aims present explore diseases, focusing leveraging technologies, such as connected care, Internet Medical Things (IoMT), remote health monitoring systems (RHMS), address rising diseases. transformative approach is exemplified in case studies tailored RHMS capabilities. showcase potential three introducing novel evaluation method their customisation proactive conditions influenced by dietary habits. RO-SmartAgeing System uniquely addresses age-related aspects, providing an integrated that considers long-term impact choices ageing, marking perspective healthcare. NeuroPredict Platform, complex neuroinformatics, enhances understanding connections between brain health, nutrition, overall well-being, contributing insights healthcare assessments. Focused liver monitoring, HepatoConect system delivers real-time data personalized recommendations, offering distinctive disease management. By integrating cutting-edge these transcend traditional boundaries.
Language: Английский
Citations
10